New hope for kids with deadly brain and nerve cancers: custom immune attack

NCT ID NCT04837547

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 35 times

Summary

This early-stage trial tests a personalized treatment for children with recurrent neuroblastoma or newly diagnosed DIPG, two aggressive cancers. The approach combines targeted drugs with a custom-made immune therapy using the child's own cells, including dendritic cells, immune cells, and stem cells. The main goal is to check safety and find the best dose, not yet to prove a cure.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Levine Children's Hospital

    Charlotte, North Carolina, 28204, United States

  • Penn State Milton S. Hershey Medical Center and Children's Hospital

    Hershey, Pennsylvania, 17033, United States

  • University of Florida

    Gainesville, Florida, 32611, United States

Conditions

Explore the condition pages connected to this study.