New hope for kids with tough cancers: personalized cell therapy trial launches

NCT ID NCT04837547

Recruiting now Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 4 times

Summary

This early-stage trial tests a personalized cell therapy for children with recurrent neuroblastoma or newly diagnosed DIPG, two aggressive cancers. The treatment uses the child's own immune cells (dendritic cells and T cells) and stem cells, trained to attack their specific tumor. The main goal is to check safety and find the best dose, with 24 participants enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized cell therapy using the child's own immune cells (dendritic cells and T lymphocytes) and stem cells
What this could lead to: If successful, this could point toward a new treatment option for children with hard-to-treat brain and nerve cancers.
What could go wrong: This is a very early (Phase 1) and small trial (24 participants) focused on safety, so it may not lead to an effective treatment. The therapy is complex and may cause side effects.

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Conditions

The condition(s) this trial relates to.

diffuse intrinsic pontine glioma neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE INTRINSIC PONTINE GLIOMA NEUROBLASTOMA

Contacts and locations

Locations

Levine Children's Hospital
ACTIVE_NOT_RECRUITING

Charlotte, North Carolina, 28204, United States
Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of Florida
RECRUITING

Gainesville, Florida, 32611, United States

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