New hope for kids with tough cancers: personalized cell therapy trial launches
NCT ID NCT04837547
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This early-stage trial tests a personalized cell therapy for children with recurrent neuroblastoma or newly diagnosed DIPG, two aggressive cancers. The treatment uses the child's own immune cells (dendritic cells and T cells) and stem cells, trained to attack their specific tumor. The main goal is to check safety and find the best dose, with 24 participants enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
personalized cell therapy using the child's own immune cells (dendritic cells and T lymphocytes) and stem cells
What this could lead to
If successful, this could point toward a new treatment option for children with hard-to-treat brain and nerve cancers.
What could go wrong
This is a very early (Phase 1) and small trial (24 participants) focused on safety, so it may not lead to an effective treatment. The therapy is complex and may cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Levine Children's Hospital
ACTIVE_NOT_RECRUITINGCharlotte, North Carolina, 28204, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Email: •••••@•••••
Contact
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University of Florida
RECRUITINGGainesville, Florida, 32611, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••