University Of Florida

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This study tested whether community health workers (CHWs) could help adults with high blood pressure who also struggle with food insecurity. 75 participants were assigned to either CHW education alone or CHW education plus extra support like grocery transportation and cooking cla…

This study looked at whether a high-protein drink with added curcumin (a compound from turmeric) could lower inflammation and oxidative stress in adults on hemodialysis for advanced kidney disease. 39 participants were randomly assigned to receive either the curcumin drink or a p…

This study tested whether a daily probiotic capsule containing Lactobacillus johnsonii N6.2 is safe for adults with type 1 diabetes and whether it affects the immune system. 46 participants took either the probiotic or a placebo for 24 weeks. Researchers monitored blood counts, m…

This study tested whether a probiotic called Lactobacillus johnsonii N6.2 is safe and affects the immune system in 30 children and teens with type 1 diabetes. The goal was to see if the probiotic could help preserve the body's ability to produce insulin by improving gut health. P…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This study tested whether donor lungs can be safely stored at 10°C (50°F) for up to 12 hours, allowing transplant surgeries to be delayed from nighttime to early morning. Forty-five patients received lungs preserved this way, and researchers checked for severe lung injury within …

This study looked at whether giving a steroid called prednisone twice a week at a lower dose, along with exercise training, could help boys with Duchenne muscular dystrophy (DMD) maintain muscle strength and function. The goal was to find a treatment that works as well as daily s…

This study tested an inhaled medication called treprostinil in 5 people with sarcoidosis who also have lung scarring and high blood pressure in the lungs. The goal was to see if the drug could improve blood flow and heart function. Participants took the drug and were monitored wi…

This study tested whether a virtual coach delivered through MyChart helps obese patients lose weight before ventral hernia surgery. Researchers compared the virtual coach to standard weight loss tools in 32 patients. The goal was to see if the coach leads to more weight loss and …

This study tested two phone-based programs to help people maintain weight loss after an initial diet. 255 adults with obesity first lost at least 5% of their body weight, then were randomly assigned to either a standard monthly check-in or an adaptive program that called more oft…

This study tested whether minocycline, an inexpensive antibiotic, can lower blood pressure in people whose hypertension doesn't respond to standard treatments. 34 adults with resistant high blood pressure took low or high doses of minocycline. The goal was to see if it could calm…

This study tested a mobile app called Family Fit, paired with a Fitbit, to see if it could help families become more active and prevent weight gain. Thirty parent-child pairs (children ages 9-12) used the app for 12 weeks. The main goal was to see if families found the app easy a…

This study looked at whether giving warm, moist oxygen through a tracheostomy tube can prevent lung complications like pneumonia or collapsed lungs after major head and neck surgery. 56 adults who had surgery with a tracheostomy were randomly assigned to receive either this high-…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This pilot study tested whether taking krill oil daily for 12 weeks helps older adults with chronic musculoskeletal pain. Forty participants aged 60 and older took either krill oil or a vegetable oil placebo. The main goal was to see if a larger trial is possible, focusing on adh…

This study tested whether giving fluoxetine (Prozac) to people with serious bone fractures could prevent or reduce depression, anxiety, and other mental health issues that often follow such injuries. 55 adults with broken bones requiring surgery were randomly assigned to take eit…

This study tested if wearing Invisalign aligners for 3 days instead of the usual 7 can still move teeth as planned. 40 adults with mild crowding wore aligners on either schedule. Researchers compared how well the predicted tooth movements matched the actual results and how fast t…

This study tested whether a nerve block (injection of numbing medicine) could reduce pain and the need for strong painkillers after septorhinoplasty, a surgery to fix a deviated nasal septum. Fifty adults received either the nerve block or a placebo. Researchers measured pain sco…

This study tested a special breathing program called Guided Respiration Mindfulness Therapy for adults with chronic low back pain. Nineteen people took part in 8 weekly one-on-one breathing sessions. The goal was to see if the therapy is practical, acceptable, and might help redu…

This study tested a group breathwork program for people with chronic musculoskeletal pain. 35 adults participated to see if the program was feasible, acceptable, and could help reduce pain. The goal was to develop a simple, group-based breathing technique that might ease symptoms…

This study tested a mobile prayer program called PUSH (Pray Until Something Happens) to see if it could help adults with sickle cell disease feel less stress and pain. 40 people who had pain and used opioids took part. They listened to guided prayer recordings on a smartphone. Th…

This study tested a mobile app called AIM2ACT that helps teens aged 12-15 with poorly controlled asthma work with their caregivers to manage symptoms. The app includes daily check-ins, goal setting, and training videos. The goal was to see if using the app improves asthma control…

This study tested a home-based digital exercise program for older adults who survived sepsis. 21 participants were assigned to either an app-guided exercise routine or standard care. The goal was to see if the program could improve physical function and be safe to use at home.

This study tested whether a self-administered oxytocin nasal spray could reduce pain and improve function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the spray or a placebo. The goal was to see if oxytocin, a natural pain-relieving hormone,…

This study looked at ways to make clear aligners (like Invisalign) better at rotating crooked canine teeth. 80 adults with rotated canines were treated with aligners using either special attachments, enamel reshaping (IPR), or both. The goal was to see which method gave the most …

This pilot study tested whether a discreet, hands-free wearable breast pump could help Black mothers of critically ill infants in the NICU pump more often and produce more milk. Forty mothers were randomly assigned to use either the wearable pump with a tracking app or a standard…

This study tested a special home rehab program for older adults (65+) to help them do everyday tasks like bathing and dressing more easily. 47 people took part, and the program was added to their usual home health therapy. The goal was to see if the extra help improved their moto…

This small study tested a technique called acute intermittent hypoxia (AIH) — breathing low-oxygen air for short periods — to see if it could improve swallowing safety in people with chronic mild-to-moderate traumatic brain injury (TBI). Five adults completed the study, which com…

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study tested whether personalized text messages, including real-time breast milk sodium levels, could help mothers of critically ill infants pump more milk. 122 mothers participated. The goal was to see if this mobile health approach is feasible and increases milk volume.

This study tested whether drinking 100% orange juice every day for 6 weeks could improve skin health in women. Twenty women with fair to medium skin tones participated. Researchers measured how the skin reacted to UV light, its moisture barrier, and overall appearance. The goal w…

This completed study tested whether regular, friendly phone calls from trained volunteers could improve mental health in older adults at risk of loneliness and suicide. Over 670 participants aged 55+ received weekly calls for 8 weeks. Researchers measured changes in loneliness, d…

This study tested a 4.5-hour somatic psychoeducational program for healthcare providers to see if it could improve their mental and physical health. Thirty-one bedside nurses participated, completing surveys and saliva tests before, one week after, and one month after the program…

This study tested whether 12 weeks of respiratory strength training could improve breathing and swallowing in a person with Friedreich's ataxia. The participant did breathing exercises against resistance and had tests before and after the training. Because only one person took pa…

This study tested whether a 12-minute guided relaxation video on a tablet could help adults with sickle cell disease manage pain and stress during a hospital stay. 46 participants were randomly assigned to watch the relaxation video or discuss their sickle cell experiences. The g…

This small pilot study tested whether a 12-week supervised walking program could help middle-aged adults with opioid use disorder reduce pain and improve mobility. Only 6 people took part, and the main goal was to see if such a program was feasible—whether people would join and s…

This study tested three different breast pump suction patterns in 96 mothers of critically ill infants who were pumping less than 350 mL per day. The goal was to see which pattern helped increase daily milk volume and maintain milk production. Mothers also rated comfort and conve…

This study aims to understand why people experience pain differently and whether the body's natural ability to manage pain can be improved through training, similar to athletic performance. Researchers will enroll 180 adults, including those with widespread muscle pain and those …

This study looked at how dry needling works for people with chronic low back pain. Researchers studied 56 adults to find out which factors make the treatment effective. The goal is to use this knowledge to offer more personalized care for back pain sufferers.

This pilot study tested whether drinking beet juice twice daily for two weeks could improve blood vessel function and breathing muscle strength in older adults with coronary artery disease. Eight participants were randomly assigned to receive either nitrate-rich beet juice or a p…

This study tested whether using a biplane ultrasound (showing two views at once) helps doctors perform caudal epidural anesthesia more effectively in children compared to standard single-plane ultrasound. The trial involved 46 boys aged 4 months to 10 years undergoing circumcisio…

This study followed 53 ICU patients who had severe abdominal infections to understand why many become frail, weak, and disabled long after leaving the hospital. Researchers measured changes in frailty, muscle loss, and overall health over 12 months. The goal was to define the nat…

This study looked at whether limiting when you eat (time-restricted eating) can improve how the body uses fuel and regulates daily rhythms in overweight adults aged 65 and older. Fifteen participants followed a set eating and fasting schedule for 8 weeks while researchers tracked…

This study looked at whether a single dose of methylphenidate (Ritalin) changes how people with both ADHD and alcohol use disorder respond to alcohol-related cues. Thirty-one adults aged 18-25 completed brain scans, EEG, and behavioral tests after taking either the drug or a plac…

This pilot study tested whether a very low carbohydrate ketogenic diet or a Mediterranean diet affects bone health and muscle function in older adults. Twelve postmenopausal adults followed each diet for six weeks. The goal was to see if these diets are safe and worth studying fu…

This study looked at 10 adults with Friedreich's ataxia to find a way to measure frataxin mRNA in blood and spinal fluid. The goal was to create a tool that can tell if treatments are working to increase frataxin levels in the brain. Researchers used tiny particles called exosome…

This study tested whether the way a catheter is pushed off the needle during IV insertion changes how much the needle tip moves. 80 people with IV experience inserted catheters into a simulator using three techniques: one-handed, two-handed, or with a helper. The goal was to find…

This study looked at brain signals in 21 people with essential tremor or Parkinson's disease during deep brain stimulation (DBS) surgery. Researchers placed temporary recording strips on the brain's surface to capture electrical activity. The goal was to learn how DBS calms the t…

This completed study followed 378 people with moderate-to-severe Lewy body dementia and their caregivers for up to three years. Researchers collected surveys and some physical exams to track symptoms, caregiver stress, and quality of life. The goal was to find clues that signal w…

This study tested a mixed-reality simulator that uses a virtual coach to train medical professionals in a procedure called REBOA, which controls severe bleeding. Fourteen participants were trained either by the virtual coach or a human instructor. The goal was to see if the virtu…

This study used a wearable ring and sleep diaries to track sleep patterns in 18 healthy older adults over six weeks. Researchers also tested their balance and thinking skills to see how these factors relate. The goal was to better understand how sleep affects mobility and brain f…

This study tested a digital conversation aid to help patients and doctors make shared decisions about thyroid biopsy. Researchers enrolled 107 adults with thyroid nodules to see if using the tool during clinic visits was practical. The goal was to gather information for planning …

This study looked at whether a dietary fiber from baker's yeast (beta-glucan) can improve how well the flu vaccine works in healthy adults aged 50 and older. 78 participants took either the supplement or a placebo before getting their flu shot. Researchers measured antibody level…

This study tested a computer tool that helps doctors and patients with chronic pain make treatment decisions together. The tool was used in primary care clinics for patients with long-term muscle or bone pain who had recently taken opioids. The goal was to see if clinics would ad…

This study looked at gut tissue from 35 people with and without high blood pressure to see if there are differences in how gut cells work. Researchers used samples taken during routine colonoscopies to compare gene activity and cell growth. The goal was to better understand how g…

This study tested a new service that lets parents call for medical help at night and get medicine delivered to their home for their sick children. Over 1,200 children with common illnesses like pneumonia, diarrhea, or malaria took part in three communities in Ghana. The goal was …

This study looked at 29 boys with autism, aged 6 to 8, to see if brain scans could reveal how sensory-based occupational therapy changes the brain. Half received a customized 16-week sensory enrichment program, while the other half served as controls. Researchers used MRI before …