Could a simple zinc pill make botox last longer for voice spasms?

NCT ID NCT05892770

Completed Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether taking zinc supplements for five days before a Botox injection into the vocal cords can extend the treatment's benefits for people with spasmodic dysphonia, a condition that causes involuntary voice spasms. Participants will take a 50 mg zinc gluconate pill each morning before their next scheduled Botox appointment. Researchers will track voice quality and quality of life over two injection cycles to see if zinc makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zinc gluconate supplement taken for five days before a Botox injection into the vocal cord muscle
What this could lead to: If zinc boosts Botox's staying power, people with spasmodic dysphonia might need fewer injections and enjoy longer periods of normal voice.
What could go wrong: This is a very early, small trial with only 32 participants. The only prior evidence comes from facial aesthetics, not voice disorders, so results may not translate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

spasmodic dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPASMODIC DYSPHONIA

Contacts and locations

Locations

University of Florida- Shands Hospital

Gainesville, Florida, 32610, United States

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