Could a probiotic help tame type 1 diabetes? new study tests safety

NCT ID NCT03961347

Completed Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a daily probiotic capsule containing Lactobacillus johnsonii N6.2 is safe for adults with type 1 diabetes and whether it affects the immune system. 46 participants took either the probiotic or a placebo for 24 weeks. Researchers monitored blood counts, metabolic panels, and any side effects like stomach discomfort. The goal was to see if this probiotic could help restore gut balance and potentially preserve insulin-producing cells.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactobacillus johnsonii N6.2 probiotic
What this could lead to: If this probiotic is shown to be safe and to improve immune balance, it could point toward a new way to help manage type 1 diabetes by supporting gut health.
What could go wrong: This is a small, early-phase trial focused on safety and immune markers, not on controlling blood sugar or curing diabetes. The probiotic may have no meaningful effect on the disease itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES (T1D)

Contacts and locations

Locations

UF Clinical Research Center

Gainesville, Florida, 32610, United States

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