University Of Florida

This early-phase study tests a new treatment for children and young adults with aggressive brain tumors called high-grade glioma and DIPG. The therapy uses the patient's own immune cells, modified in a lab to better recognize and attack tumor cells. The main goals are to see if t…

This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standa…

This phase 2 trial tests a combination of two drugs, enfortumab vedotin and pembrolizumab, given before surgery to people with muscle-invasive bladder cancer or upper tract urothelial carcinoma. The goal is to see if the drugs can shrink or eliminate the cancer enough that some b…

This study tests whether giving a Pfizer-BioNTech COVID-19 mRNA vaccine before standard immunotherapy (pembrolizumab) and chemotherapy can improve outcomes for people with stage 4 non-small cell lung cancer. Researchers will enroll 500 adults to see if the vaccine helps the immun…

This early-phase trial tests a new type of immunotherapy for adults with brain metastases from various cancers. The treatment uses the patient's own immune cells, modified to better target and attack tumor cells. The main goals are to see if the approach is safe and feasible in 1…

This study tests whether adding ivermectin, a drug used for parasitic infections, can improve the immune response in people with solid tumors who are already receiving immunotherapy. About 80 adults will take either a moderate or high dose of ivermectin for four weeks alongside t…

This pilot study tests whether an AI-based system can help doctors choose the right doses of immunosuppressant drugs for kidney transplant patients. The goal is to protect the new kidney from damage and rejection. The study will enroll 34 adults who have received a deceased donor…

This study will test a new computer tool that helps emergency doctors spot patients at high risk for hepatitis C and HIV. The tool uses a machine learning algorithm to analyze patient data and pops up an alert for the doctor. Researchers will compare this targeted screening with …

This study tests a six-session behavioral program for stimulant-using men at high risk for HIV. The program focuses on positive thinking, mindfulness, and building supportive networks to help participants start taking PrEP (a daily pill that prevents HIV) and reduce stimulant use…

This study tests if digital videos and tips can help prevent obesity in babies during their first year. About 50 mothers in a home visiting program will watch short modules on feeding, sleep, and activity. Researchers will check the babies' weight and ask mothers about their habi…

This study looks at whether doing special breathing exercises for at least two weeks before breast cancer surgery can keep the breathing muscles strong. About 40 adults recently diagnosed with breast cancer will either do breathing muscle training or guided imagery exercises at h…

This study tests whether three months of flicker stimulation (using near-infrared light or visual occlusion glasses) can improve thinking, movement, and mood in healthy older adults and those with subjective cognitive decline. Sixty participants aged 65-89 will be assigned to dif…

This study will compare a new powered prosthetic knee called the Bio-Leg to the current standard C-Leg in 12 adults who have lost a leg above the knee. Participants will use their own C-Leg first, then switch to the Bio-Leg for 4-6 weeks. Researchers will measure how far they can…

This study tests whether a special light treatment, called photobiomodulation, can reduce pain and swelling in people with long-term knee osteoarthritis. Researchers will measure pain levels before and after treatment in 30 adults aged 50 and older. The goal is to find a drug-fre…

This study tests whether combining a gentle brain stimulation technique (rTMS) with walking and eye exercises can improve balance and reduce fall risk in 30 adults aged 18-80 with or without mild cognitive impairment. Participants will practice stepping onto targets while their e…

This study tests whether a smartphone app called the Cancer Exercise app (CEA) can help cancer survivors become more physically active. About 750 adults who have finished cancer treatment will either use the app for 12 weeks or receive usual care. The goal is to see if the app bo…

This study tests a brain stimulation treatment called TMS to help female athletes with both depression and concussion symptoms. About 35 women aged 18-65 who have had a concussion and have moderate to severe depression will receive the treatment. The goal is to see if TMS can imp…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can reduce stress during performance tasks like public speaking. Two hundred adults will be randomly assigned to receive either active or placebo stimulation while completing a stressful spee…

This pilot study will test whether a special form of kava (AB-free kava) can improve mobility and physical function in adults over 70 who have mild sleep problems and are somewhat inactive. Forty participants will take either kava capsules or a placebo daily for a period, and res…

This pilot study tests whether using a large language model (LLM) AI chatbot can help people increase their physical activity. 39 adults who want to be more active will be split into three groups: one uses the AI on their own, one gets extra guidance on using the AI, and one uses…

This study will compare how well two types of clear aligners—one made by 3D printing and the other by traditional thermoforming—fit onto teeth. Twenty healthy adults will wear passive aligners, and the fit will be measured at several time points over two weeks. The goal is to see…

This study tests a special blood pressure monitor that deflates very slowly, designed for people with a Left Ventricular Assist Device (LVAD). Researchers want to see if patients can use it easily at home and if it helps track their blood pressure accurately. About 50 adults with…

This study looks at how alcohol affects thinking skills and brain activity in healthy adults aged 65 to 80 who drink regularly. Over two lab visits, 80 participants will complete questionnaires and mental tasks while receiving either an alcoholic or a placebo drink. The goal is t…

This study looks at how resilience and pain sensitivity influence physical function in people with fibromyalgia compared to healthy volunteers. Researchers will measure walking distance using a 6-minute walk test and compare it to self-reported resilience scores. No treatment is …

This study from the University of Florida will give parents of toddlers in daycare three different thermoses to send breastmilk in. Parents and daycare providers will fill out weekly surveys about any problems, and staff will check the milk's temperature at lunch and snack time t…

This study tests a web-based program for people who are worried about their romantic partner's drinking. The program teaches skills like self-care and positive communication. Researchers will first study 50 couples to understand daily patterns, then develop the program with 15 pa…

This study looks at whether a single dose of methylphenidate (Ritalin) changes how the brain responds to alcohol-related images in young adults aged 18-25 with alcohol use disorder. Participants will have brain scans and complete tasks after taking either the drug or a placebo. T…