New antibody drug aims to save Insulin-Making cells in type 1 diabetes
NCT ID NCT07670650
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standard diabetes care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SAB-142 (a lab-made antibody that targets immune cells)
What this could lead to
If it works, SAB-142 could help people with type 1 diabetes keep making some of their own insulin for longer, reducing the need for injected insulin.
What could go wrong
This is an early Phase 3 trial with only 108 participants, so results may not apply to everyone. The drug may not preserve insulin production better than placebo, and there are risks from the immune-suppressing effects of the antibody.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Barbara Davis Center for Diabetes
Aurora, Colorado, 80045, United States
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IUH - Riley Hospital for Children - Riley Outpatient Center - Pediatric Diabetes & Endocrinology
Indianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco Benioff Children's Hospital
San Francisco, California, 94158, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida
Gainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact