New engineered graft aims to improve stem cell transplants for kids with leukemia
NCT ID NCT05322850
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a specially engineered donor graft called Orca-Q in children and young adults with blood cancers who need a stem cell transplant. The graft is designed to help the new cells take hold and reduce complications. The trial is currently on hold, but aims to enroll 40 participants to see if the approach is safe and works better than standard transplants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Orca-Q (engineered donor graft)
- What this could lead to
- If successful, this could make stem cell transplants safer and more effective for children with blood cancers, reducing complications like graft failure.
- What could go wrong
- This is an early-phase trial (Phase I/II) with only 40 participants, so results may not apply broadly. The trial is currently suspended, and there are risks of graft failure or other serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
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Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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University of Florida
Gainesville, Florida, 32608, United States
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University of Miami
Miami, Florida, 33136, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Talking about the end: could guided conversations reduce futile cancer treatments?