New engineered graft aims to improve stem cell transplants for kids with leukemia
NCT ID NCT05322850
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a specially engineered donor graft called Orca-Q in children and young adults with blood cancers who need a stem cell transplant. The graft is designed to help the new cells take hold and reduce complications. The trial is currently on hold, but aims to enroll 40 participants to see if the approach is safe and works better than standard transplants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Orca-Q (engineered donor graft)
What this could lead to
If successful, this could make stem cell transplants safer and more effective for children with blood cancers, reducing complications like graft failure.
What could go wrong
This is an early-phase trial (Phase I/II) with only 40 participants, so results may not apply broadly. The trial is currently suspended, and there are risks of graft failure or other serious side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
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Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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University of Florida
Gainesville, Florida, 32608, United States
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University of Miami
Miami, Florida, 33136, United States