Could less radiation be enough for HPV throat cancer?
NCT ID NCT05268614
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether giving less radiation, based on a patient's HPV type and levels of HPV DNA in the blood, can control throat cancer as well as standard higher doses. About 250 adults with favorable-prognosis oropharyngeal cancer will receive 70, 60, or 50 gray of radiation depending on their risk profile. The goal is to maintain cancer control while reducing treatment side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy (dose adjusted based on HPV subtype and DNA levels)
What this could lead to
If successful, this could show that many patients with HPV-related throat cancer can safely receive lower doses of radiation, reducing side effects while still controlling the cancer.
What could go wrong
This is a Phase 2 trial with 250 participants, so results are not yet proven. There is a risk that lower radiation doses may not control the cancer as well as standard treatment.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UF Health Proton Therapy Institute
RECRUITINGJacksonville, Florida, 32206, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Florida
RECRUITINGGainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••