Can exercise and brain training fix memory after a head injury?

NCT ID NCT05716048

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at whether combining a memory-training program with aerobic exercise can help people with moderate to severe traumatic brain injury (TBI) improve their learning and memory. Sixty adults with TBI will be randomly assigned to either memory training plus aerobic exercise or memory training plus stretching. The goal is to see if adding exercise leads to better memory, brain changes, and daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cognitive rehabilitation (KF-mSMT) plus aerobic exercise training

What this could lead to

If it works, this could offer a new, non-drug way to improve memory and daily life for people with traumatic brain injury.

What could go wrong

This is a small, early-phase trial (60 people) testing a behavioral intervention, so results may not apply broadly. The benefit may be modest or not translate to real-world improvements.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Kessler Foundation

    RECRUITING

    West Orange, New Jersey, 07052, United States

    Contact