Can exercise and brain training fix memory after a head injury?

NCT ID NCT05716048

Recruiting now Symptom relief Sponsor: Kessler Foundation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at whether combining a memory-training program with aerobic exercise can help people with moderate to severe traumatic brain injury (TBI) improve their learning and memory. Sixty adults with TBI will be randomly assigned to either memory training plus aerobic exercise or memory training plus stretching. The goal is to see if adding exercise leads to better memory, brain changes, and daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cognitive rehabilitation (KF-mSMT) plus aerobic exercise training
What this could lead to: If it works, this could offer a new, non-drug way to improve memory and daily life for people with traumatic brain injury.
What could go wrong: This is a small, early-phase trial (60 people) testing a behavioral intervention, so results may not apply broadly. The benefit may be modest or not translate to real-world improvements.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Kessler Foundation
RECRUITING

West Orange, New Jersey, 07052, United States

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