TRAUMATIC BRAIN INJURY

This study tested whether adding ear acupuncture to standard care helps patients with severe brain injuries wake from coma. Researchers divided 60 patients into two groups: one received standard care plus nerve stimulation, while the other received the same plus tiny needles plac…

This study tested whether infusing a patient's own stem cells is safe and might help the brain heal after a traumatic injury. It involved 24 adults with brain injuries that happened more than six months prior. Researchers looked for changes in brain scans, thinking skills, and qu…

This study tested whether adding two medications, Cerebrolysin and Amantadine sulfate, to standard ICU care could help people recover better from a serious traumatic brain injury (TBI). It involved 150 adults with moderate to severe TBI. Researchers measured changes in consciousn…

This study tested whether special high-fat, low-carb diets (ketogenic or modified Atkins) could help people recover brain function after a moderate to severe traumatic brain injury. Researchers enrolled 21 recent brain injury patients to see if these diets improved their thinking…

This study compared two anesthesia drugs (dexmedetomidine and sufentanil) to see which one better maintains oxygen levels in the brain during surgery for traumatic brain injury. Researchers monitored 28 patients using a special forehead sensor to measure brain oxygen before, duri…

This study tested whether a support program called 'Resource Facilitation' helps people recover after a traumatic brain injury. Participants worked one-on-one with a brain injury specialist to set and achieve personal goals. The goal was to see if this approach improved quality o…

This small pilot study tested whether a non-invasive device that stimulates a nerve in the neck could help prevent severe lung injury in people recently hospitalized for a mild-to-moderate traumatic brain injury. The device was used alongside standard hospital care and compared t…

This study tested if playing an immersive computer game that combines physical and mental challenges could help adults with a past traumatic brain injury (TBI). Researchers wanted to see if the game could improve memory, thinking skills, and mood, and possibly reduce the long-ter…

This study tested two different ways to feed patients with severe brain injuries who have a breathing tube. Researchers compared a newer mouth-to-esophagus tube method against the standard nose-to-stomach tube to see which one led to better nutrition, fewer complications, and fas…

This study tested whether a personalized magnetic brain stimulation therapy could help reduce symptoms of Post-Traumatic Stress Disorder (PTSD). 158 adults with PTSD received either the real treatment or a placebo version for 5 weeks, with neither participants nor doctors knowing…

This small pilot study explored whether a high-fat, low-carb ketogenic diet is safe and practical to use in children recovering from moderate to severe traumatic brain injuries. Researchers wanted to see if children could tolerate the special diet for 14 days and gather early inf…

This study tested whether a breathing treatment called acute intermittent hypoxia (AIH) could help improve swallowing safety in people with chronic traumatic brain injury. Participants were adults with mild-to-moderate brain injuries who received either the breathing treatment pl…

This study tested two community-based wellness programs to see if they could improve health, increase life satisfaction, and reduce healthcare costs for adults with disabilities like cerebral palsy or spinal cord injury. It involved 130 participants who were eligible for specific…

This study tested whether a portable goggle system could reliably diagnose mild traumatic brain injuries (like concussions) in community medical settings like urgent care or emergency departments. Researchers enrolled 120 adults who had recently suffered a head impact, along with…

This study tested new methods to monitor harmful brain wave patterns in patients with traumatic brain injury (TBI). Researchers compared a less invasive scalp sensor (EEG) to more invasive brain surface sensors to see if the scalp method could reliably detect these damaging event…

This study tested a one-year support program for Veterans diagnosed with Alzheimer's disease or traumatic brain injury and their family caregivers. The program aimed to improve the quality of life for both the Veteran and the caregiver while reducing the stress and burden felt by…

This study tested whether an 8-week, high-intensity exercise program could improve mobility in daily life for people with neurologic disabilities like stroke, cerebral palsy, or spinal cord injury. Fifteen participants aged 8-99 took part in the program, which was run by physical…

This study tested whether a 12-week treadmill walking program could help adults who had a traumatic brain injury. Researchers wanted to see if regular aerobic exercise could improve their physical fitness, reduce severe fatigue, and help with mood. Participants completed exercise…

This study looked at whether learning to train a future service dog, combined with standard medical care, could help reduce symptoms of post-traumatic stress (PTS) and post-concussive symptoms in military members. Researchers enrolled 156 participants to measure changes in stress…

This study tested whether a gentle, non-invasive electric stimulation to the brain could help people with a history of traumatic brain injury who struggle to find words. Five civilian participants received either real or fake stimulation over 10 sessions to see if it improved the…

This study tested if a therapy called Behavioral Activation could help Veterans with depression after a traumatic brain injury (TBI). About 40 Veterans received either this therapy plus their usual care, or just their usual care. The therapy involved six sessions over three month…

This study tested whether a dietary supplement called branched chain amino acids (BCAAs) could improve sleep and thinking problems in Veterans with mild traumatic brain injury (mTBI). 160 participants were randomly assigned to take either the supplement or a placebo for 12 weeks.…

This study tested whether a 12-week online support group could help brain injury survivors and their caregivers. Researchers wanted to see if teaching coping skills over video calls was practical and helpful. The group aimed to boost confidence in managing daily challenges and im…

This study tested if simple behavioral tools could help older adults who had a past mild or moderate traumatic brain injury (TBI) become more physically active. For 12 weeks, 57 participants wore a Fitbit and received weekly phone calls. One group used planning, text/email remind…

This study tested whether using a virtual reality (VR) app at home could help improve memory, attention, and thinking skills in adults 65 and older who had a mild traumatic brain injury (like a concussion). Researchers compared a group doing VR cognitive exercises to a control gr…

This study tested whether a 12-week online support group could help brain injury survivors and their caregivers learn coping skills and improve their emotional well-being. Researchers compared the online version to an established in-person program to see if remote delivery was ju…

This study tested whether morning bright light therapy could help veterans with mild traumatic brain injury sleep better and reduce their chronic pain. Researchers enrolled 77 veterans who had both sleep problems and persistent pain. They wanted to see if this simple, non-drug li…

This study tested a distance-learning program to train family caregivers of people with Alzheimer's dementia or traumatic brain injury (TBI). The goal was to teach strategies to reduce care-resistant behaviors—like agitation or aggression during bathing or taking medicine—to impr…

This study tested if a lidocaine spray given through a breathing tube could help prevent dangerous spikes in brain pressure when nurses suction mucus from the lungs of children with severe head injuries. It compared the spray to a liquid lidocaine drip and a saltwater drip in 10 …

This small, completed pilot study tested whether adding electrical stimulation to standard wound care helps heal stubborn pressure wounds. It involved 20 adults with spinal cord or brain injuries whose wounds hadn't improved after a month of regular care. The study measured chang…

This study tested whether an interactive touch screen device helps improve visual field awareness better than traditional pen-and-paper exercises. It involved 37 adults undergoing inpatient rehabilitation after strokes or brain injuries who had visual field problems. Participants…

This study tested whether the medication buspirone helps reduce anger, irritability, and aggression in people living with traumatic brain injury (TBI). 81 adults with TBI and significant irritability were randomly assigned to receive either buspirone or a placebo pill for 91 days…

This study tested whether a gentle, non-invasive form of brain stimulation could improve memory in older adults. It focused on people with mild memory problems (amnestic mild cognitive impairment) who also had a past traumatic brain injury. Participants received 10 sessions of st…

This study tested whether a single-day group workshop could help veterans dealing with the combined effects of mild brain injury, chronic pain, PTSD, depression, or anxiety. The workshop taught life skills to help manage distress and improve daily functioning, aiming to be more a…

This study tested whether a gentle, non-invasive electric stimulation to a specific part of the brain could help people with a history of traumatic brain injury who have trouble finding words. Fourteen civilian participants received either real or fake (sham) stimulation over ten…

This study tested whether a 12-week exercise program called 'movement-to-music' (M2M) could improve fitness and well-being in adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. 108 participants were randomly assigned to either start the prog…

This study tested if a single session of moderate cycling, done in different environments, could temporarily improve thinking skills in adults with a past traumatic brain injury (TBI). Researchers measured changes in multitasking, memory, and focus after the exercise. The goal wa…

This small, completed pilot study tested whether a personalized program combining talk therapy, brain training exercises, and lifestyle advice is practical and helpful for people with thinking problems from conditions like brain injury, multiple sclerosis, or mild memory loss. Th…

This study tested a group workshop called STEP-Home, designed to help post-9/11 Veterans who were struggling to adjust after military service. The workshop taught practical skills for managing emotions, solving problems, and focusing attention to improve daily life and community …

This study tested a new smartphone app called MEMI, designed to help adults with long-term memory problems from a past traumatic brain injury. Researchers wanted to see if the app was easy to use and if its method of giving short, frequent memory practice sessions throughout the …

This study tested whether a home exercise program or bright light therapy could help adults with traumatic brain injury. Researchers compared the effects of three months of each therapy on movement, balance, thinking, and mood. The goal was to find new ways to improve daily funct…

This study developed new MRI techniques to measure how the brain moves and deforms during mild head motions in healthy volunteers. Researchers scanned 101 healthy adults aged 18-65 while they performed controlled head movements in an MRI machine. The goal was to create detailed 3…

This study observed 69 patients aged 40+ with confirmed traumatic brain injuries to collect information about their health, treatments, and recovery. Researchers tracked existing medical care without giving any experimental treatments, aiming to identify patterns and best practic…

This study collected detailed brain monitoring data from 162 patients with various brain injuries to build a database for future research. Participants had existing pressure monitors, and researchers used a noninvasive ultrasound device to record blood flow signals. The goal was …

This small study tested if a portable brain scanner (fNIRS) could be used safely and effectively to measure brain activity in people with chronic traumatic brain injury (TBI) while they walked on a treadmill using virtual reality (VR). The goal was to see if this technology could…

This study looked at whether a sedative drug called dexmedetomidine reduces inflammation after brain surgery for traumatic injury. Researchers compared inflammation levels in 25 patients who received the drug during surgery with those who did not. The goal was to gather informati…

This study analyzed data from 50 patients who had already been treated for severe traumatic brain injury or a type of brain bleed. Researchers looked back at detailed brain monitoring records to understand how changes in treatment affected blood flow and oxygen in the brain. The …

This study aimed to create a database of people with traumatic brain injury (TBI) to help recruit them for future research projects. Over 1,300 adults with TBI symptoms were enrolled. Participants provided medical information and contact details so researchers could reach out to …

This study aimed to understand why some people develop severe fatigue and cognitive problems after a traumatic brain injury (TBI). Researchers analyzed genetic data from 68 patients with TBI and these specific symptoms, comparing it to a large database of medical records. The goa…

This study aimed to better understand swallowing problems in patients with severe traumatic brain injury who have altered consciousness. Researchers examined 34 patients using special swallowing tests and consciousness assessments. The goal was to identify patterns and connection…

This study aimed to better understand what happens to the brain after a head injury. Researchers followed 886 adults who had recently experienced a suspected traumatic brain injury, using MRI scans and other tests over several months. The goal was to gather detailed information t…