TRAUMATIC BRAIN INJURY

This study tested whether giving two drugs—cerebrolysin and amantadine sulfate—together with standard care helps people recover from moderate to severe traumatic brain injury in the ICU. 150 adults aged 18 to 70 took part. Researchers measured consciousness, disability, and recov…

This study looked at whether a ketogenic or modified Atkins diet can improve brain function and recovery in people with moderate to severe traumatic brain injury. Twenty-one adults who were recently injured took part. The goal was to see if changing the brain's fuel source could …

This small pilot study tested a non-invasive device that stimulates the vagus nerve (a key nerve connecting the brain and body) in people hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if this stimulation, added to standard care, could prevent seve…

This study tested whether a person's own stem cells, given through an IV, are safe and might help improve brain function after a traumatic brain injury. 24 adults with long-term brain damage received the treatment. The main goal was to check safety, but researchers also looked fo…

This study tested whether a portable goggle system (I-PAS) can reliably diagnose mild traumatic brain injury (mTBI) in community settings like urgent care or emergency rooms. Researchers enrolled 120 adults aged 18-50 who had a head injury with symptoms like loss of consciousness…

This study tested whether virtual reality exercises can improve memory and thinking in older adults (65+) who had a mild traumatic brain injury. Thirty participants used VR cognitive exercises at home for 6 weeks. The goal was to see if VR could help with attention, memory, and v…

This study tested whether a dietary supplement of branched-chain amino acids (BCAAs) could improve sleep and thinking in 160 veterans with mild traumatic brain injury. Participants took either the supplement or a placebo for several months. The goal was to see if the treatment wa…

This study tested a distance-learning program that trains family caregivers to reduce care-resistant behaviors (like agitation or aggression) in people with Alzheimer's dementia or traumatic brain injury. About 88 participants and their unpaid caregivers took part. The goal was t…

This study tested whether a high-intensity exercise program, run by physical therapy students, helps people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program. Th…

This small study tested a noninvasive LED light treatment on 8 veterans with mild traumatic brain injury (TBI) and blast exposure. The goal was to see if the light could improve thinking, memory, mood, and quality of life. Researchers measured changes using standard tests for att…

This study tested whether a gentle, low-level electric stimulation to a specific part of the brain (the pre-supplementary motor area) could help people with a past traumatic brain injury recall words more easily. Fourteen adults with word-finding difficulties that started after t…

This study tested whether morning bright light therapy could improve sleep, reduce pain, and enhance daily function in 77 veterans with chronic mild traumatic brain injury (mTBI). Participants had ongoing sleep problems and moderate-to-severe pain. The goal was to see if a simple…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 26 adults aged 50+ with mild cognitive impairment and a history of traumatic brain injury. Participants received 10 sessions targeting a brain region linked to memory. The goal was to see if this could…

This study looked at ways to help people with traumatic brain injury who struggle with irritability and aggression. Researchers tested different treatments to see if they could improve behavior control. The study involved 81 adults who had a closed head injury at least six months…

This study tested whether a program combining cognitive behavioral therapy, cognitive rehabilitation, and lifestyle coaching is practical and helpful for people with mild cognitive impairment, traumatic brain injury, multiple sclerosis, or long COVID. Fifteen participants receive…

This study tested whether a gentle electric current applied to a memory-related brain area can improve word-finding in civilians who had a traumatic brain injury at least a year ago. Five adults with ongoing word retrieval problems received both real and fake stimulation in a con…

This study tested whether a 12-session coping skills group delivered via telemedicine could help brain injury survivors and their caregivers feel more confident and emotionally stable. Thirteen participants joined from home. The goal was to see if this approach is practical and h…

This study looked at whether a 12-week treadmill walking program could boost physical fitness, reduce fatigue, and improve mood in people with traumatic brain injury (TBI). Thirteen adults with TBI who were not physically active took part. They exercised three times a week, and r…

This study looked at whether giving N-Acetylcysteine (an antioxidant) plus multivitamins soon after a traumatic brain injury helps older adults (60+) feel better. 92 people took part, and researchers checked their thinking, emotions, and physical symptoms over 30 days. The goal w…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble readjusting to civilian life. The workshop taught practical skills like managing emotions, solving problems, and paying attention, without calling it therapy to make it more welcoming. The go…

This study tested a program designed to help veterans with Alzheimer's disease or traumatic brain injury and the family or friends who care for them. The goal was to see if the program could improve quality of life and reduce caregiver burden. About 236 veterans and their caregiv…

This study tested whether adding ear acupuncture (with tiny press needles) to standard care and nerve stimulation could help people with traumatic brain injury regain consciousness. Sixty patients with severe brain injury were split into two groups; one group got the ear acupunct…

This study tested a one-day life skills workshop for 176 veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The goal was to help them cope better and reintegrate into civilian life. The workshop focused on practical ski…

This study looked at whether a 3-month home exercise program and a 3-month bright light therapy program could improve movement, balance, thinking, and mood in adults with traumatic brain injury (TBI). 34 people with TBI and healthy volunteers took part. The goal was to see if the…

This study tested whether breathing low-oxygen air in short bursts (acute intermittent hypoxia) can boost the brain's ability to improve swallowing safety in people with chronic mild-to-moderate traumatic brain injury. Five adults completed the trial, which paired the breathing t…

This study tested a therapy called behavioral activation (BA) for veterans with traumatic brain injury (TBI) and depression. BA helps people set goals and do meaningful activities to improve mood. 46 veterans took part, with some getting BA plus usual care and others only usual c…

This study tested whether using a touch screen system (BITS) could help people with vision problems caused by a stroke or brain injury. 37 adults in rehab were split into two groups: one did standard pen-and-paper vision exercises, the other used the touch screen. The goal was to…

This study tested a personalized magnetic therapy called MeRT for people with PTSD. 158 adults received either real or fake (sham) treatment to see if it safely reduces symptoms. The main goal was to measure changes in PTSD symptoms using a standard checklist.

This study tested a telemedicine version of a coping skills group for people with brain injuries and their caregivers. The goal was to help them feel more confident in managing daily challenges. About 49 adults who were at least six months post-injury took part in the online grou…

This study tested a 12-week exercise program set to music for 108 adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. Participants were randomly assigned to the music exercise group or a waitlist. The goal was to see if the program improved h…

This small pilot study looked at whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults who had bedsores that didn't improve after four weeks of sta…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had a mild traumatic brain injury from a blast. The program aimed to improve thinking skills and quality of life. Participants were OEF/OIF veterans aged 21-50 with brief …

This study tested whether spraying lidocaine into the breathing tube before suctioning could prevent dangerous spikes in brain pressure in children with severe traumatic brain injury. Ten children in the ICU were given lidocaine either as a spray or as drops, and their brain pres…

This study looked at whether learning to train a future service dog, along with usual care, can improve symptoms of post-traumatic stress (PTS), anxiety, depression, and pain in military members. 156 active-duty and retired service members with PTSD or mild traumatic brain injury…

This study used MRI scans to measure how the brain moves inside the skull during gentle head motions, like turning your head. Researchers studied 90 healthy adults aged 18-65 to create a database of normal brain movement. The goal was to develop a new imaging method that could he…

This study looked at 98 people with severe traumatic brain injury who needed a breathing tube. Researchers compared two ways of giving nutrition: a tube that goes through the mouth into the esophagus versus a tube through the nose into the stomach. They checked blood markers, wei…

This study tested a program to help nurses better support relatives of people with serious brain injuries or brain tumors. The program included a dialogue tool, training for nurses, and videos for families. The goal was to see if this approach could improve how involved and suppo…

This study looked at 68 adults with a history of traumatic brain injury who also had fatigue and trouble thinking. Researchers used machine learning to search for specific genetic markers that might be linked to these symptoms. The goal was to better understand why some people de…

This study aims to identify and evaluate people with traumatic brain injury (TBI) or post-concussive syndrome to see if they qualify for future research studies. Participants will undergo interviews, medical history reviews, physical exams, and possibly blood tests and MRI scans.…

This study tested a new web-based tool designed to help families of patients with severe brain injuries (like stroke or traumatic brain injury) communicate with doctors and make decisions about care goals. The study enrolled 50 family decision-makers to see if the tool was easy t…

This study looked at two new methods to measure how well the brain controls its own blood flow after a serious injury in children. Researchers monitored 29 children in the intensive care unit using special analysis of blood pressure and brain oxygen levels. The goal was to find b…

This study looked at whether a sedative called dexmedetomidine can lower inflammation after brain surgery in people with traumatic brain injury. Researchers measured C-reactive protein (CRP), a marker of inflammation, in 25 patients who either received the drug or did not. The go…

This study tested a phone app called MEMI designed to help adults with chronic traumatic brain injury improve their memory. 40 participants used the app to practice remembering words. The goal was to see if the app was easy to use and if it actually helped memory.

This study tested a free service called Resource Facilitation for people who have had a traumatic brain injury (TBI). Participants worked one-on-one with a brain injury specialist to set and reach personal goals. The study included 90 adults with a documented TBI. Researchers mea…

This study collected brain signals from 162 patients with brain injuries to create a database for developing noninvasive ways to measure pressure inside the skull. Participants had an existing pressure monitor and also wore a harmless ultrasound device on their head. The goal is …

This study gathered information from 69 older adults (age 40 and up) who had a traumatic brain injury (TBI) confirmed by CT scan. Researchers looked at patients' health history, frailty, and treatments to find patterns that lead to better recovery. No new treatments were tested—t…

This study looked at whether playing an immersive computer game that mixes physical movement with mental challenges can improve thinking, memory, and brain structure in adults aged 40 and older who had a traumatic brain injury (TBI) years ago. 23 participants completed the 12-wee…

This study looks back at data from 50 patients who had severe brain injuries (from trauma or bleeding) and were treated in the ICU. Researchers want to analyze how different monitoring tools, like blood flow and oxygen sensors, can help detect problems earlier and guide personali…

This study looked at new ways to monitor brain activity in people with traumatic brain injury (TBI). Researchers tested special electrodes placed in the brain and on the scalp to detect spreading depolarizations, which are waves of brain activity that can cause damage. The goal w…

This study looked at people who had a recent head injury to learn more about how traumatic brain injury (TBI) affects the brain over time. Researchers used MRI scans and thinking tests to track changes for up to three months after the injury. The goal was to find better ways to d…

This study tested two sedatives, dexmedetomidine and sufentanil, in 28 people with traumatic brain injury having surgery. The goal was to see which drug better maintains brain oxygen levels during and after the operation. Researchers measured oxygen in the brain using a special l…

This study looked at whether a single session of moderate cycling in different environments (like indoors vs. outdoors) can improve thinking speed and multitasking in adults with traumatic brain injury. 24 participants completed cycling sessions, and researchers measured changes …

This small pilot study looked at whether a ketogenic (high-fat, low-carb) diet is safe and doable for children who have had a moderate to severe traumatic brain injury. Seven children took part, and the goal was to see if they could stay on the diet for 14 days without serious si…

This study looked at swallowing problems in 34 patients with severe traumatic brain injury who have minimal consciousness. Researchers used a special X-ray video to see how well patients could swallow. The goal was to better understand these swallowing issues and how they relate …

This study looked at whether simple tools like planning, phone reminders, and small rewards can encourage older adults who had a mild or moderate traumatic brain injury (TBI) to walk more. Over 12 weeks, 57 participants wore a Fitbit and received weekly check-in calls. The goal w…

This study looked at whether a portable brain imaging device (fNIRS) can safely and effectively measure brain activity in people with chronic traumatic brain injury while they walk on a treadmill with virtual reality. Eight participants completed the sessions, and researchers che…

This study tested two community-based wellness programs for 130 adults with disabilities such as spina bifida, cerebral palsy, spinal cord injury, or traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. …