TRAUMATIC BRAIN INJURY

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug improves daily function…

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). The program, called Group Lifestyle Balance, focuses on healthy eating and physical activity. Researchers will track weight, step count, and other health measures over 18 months in 57 ad…

This study tests a weight-loss program delivered by video for people with traumatic brain injury (TBI). The program is based on the Diabetes Prevention Program and is adapted for TBI. About 85 adults with moderate to severe TBI and a BMI of 25 or higher will take part. The goal i…

This study tests whether certain FDA-approved drugs, used off-label, can help people recover better after a traumatic brain injury (TBI). About 672 adults with moderate to severe TBI will receive either a study drug or a placebo within 24 hours of injury. Recovery is measured by …

This study tests whether a natural hormone called pregnenolone can improve mental health, thinking, and pain in veterans who had a mild traumatic brain injury (TBI) years ago. About 108 veterans will take either the hormone or a placebo daily for 8 weeks. Researchers will check f…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve memory and daily living skills in veterans who had a mild traumatic brain injury more than a year ago. About 41 participants will receive either real tDCS or a sham (fake) version while do…

This study tests a program called BETTER that provides education, training, and therapy to adults with traumatic brain injury and their families after they leave the hospital. The goal is to improve quality of life and thinking skills compared to usual care. About 500 participant…

This study tests a new type of magnetic brain stimulation for people with ongoing symptoms after a mild concussion. Fifteen adults will receive 30 short treatment sessions and have detailed MRI scans before and after. The goal is to see if this treatment reduces symptoms and impr…

This pilot study is testing whether virtual reality treadmill training can help people with traumatic brain injury improve their balance, mobility, and confidence. Twenty adults aged 18 to 90 who have had a TBI at least one year ago and have balance issues or a history of falls w…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Researchers will also check if better sleep affects thinking, mood, and certain blood markers. The entire study can be done from home.

This study is testing a set of virtual reality games (exergames) in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. The games include cooking together, solvi…

This study looks at children aged 3 to 16 with severe head injuries to understand what causes further brain damage after the initial injury. Researchers are testing whether special monitors that track oxygen and chemical levels in the brain can provide useful information beyond s…

This study was designed to test a program that helps caregivers of people with traumatic brain injury improve their problem-solving skills. It planned to enroll adults aged 19 and older, but was withdrawn before any participants joined. No results are available.

This study aimed to create a database of high-frequency brain signals to better understand epilepsy, migraines, and other brain conditions. It planned to use advanced software to map brain functions in healthy volunteers. However, the study was withdrawn before enrolling anyone, …

This study watches people with brain conditions like traumatic brain injury, cerebral palsy, or Alzheimer's who choose to get special nasal treatments with stem cells or exosomes. Researchers do not give the treatment but collect safety data and measure inflammation markers in th…

This study tests a remote therapy program called ICARE for people with traumatic brain injury (TBI) and their care partners. The goal is to see if it's practical and helpful for improving how TBI patients recognize and respond to others' emotions. About 85 participants who are at…

This study follows 1,500 adults aged 65 and older who have had a traumatic brain injury (TBI), along with similar healthy participants. Researchers will track their recovery over 12 months using brain scans, blood tests, and health history. The goal is to create better tools for …

This study looks at how a serious injury or burn that requires intensive care might affect thinking skills like memory and decision-making over time. Researchers are following 432 adults to see if long-term cognitive problems develop and how inflammation in the body might play a …

This study tests a special program for prisoners with traumatic brain injury (TBI) who are about to be released. The program provides support and skills training to help them avoid returning to prison and reduce violent behavior. About 102 participants will be randomly assigned t…

This study tests a new therapy designed to help veterans with traumatic brain injury (TBI) improve how they tell stories and communicate in everyday life. The therapy focuses on both the content and organization of stories. The study includes 34 veterans and checks if the treatme…

This study follows 300 people who had a traumatic brain injury (TBI) to better understand how epilepsy can develop years later. Researchers will check participants' recovery and watch for seizures using interviews and blood tests. The goal is to learn more about the long-term eff…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal for the brain. About 728 adults on ventilators w…