TRAUMATIC BRAIN INJURY

This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug leads to better functio…

This study tests whether certain FDA-approved drugs, used off-label, can help people recover better after a traumatic brain injury (TBI). About 672 adults with moderate to severe TBI will receive either an experimental drug or a placebo within 24 hours of their injury. The main g…

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). About 57 adults with moderate to severe TBI and a BMI of 25 or higher will join. The program focuses on healthy eating and physical activity, tracking weight, step count, and blood press…

This study tests a weight-loss program delivered via telehealth, specifically designed for people with traumatic brain injury (TBI). The program is adapted from the Diabetes Prevention Program and addresses unique needs of TBI patients. Researchers aim to see if the program helps…

This study compares two types of brain surgery for people with a severe head injury that causes a blood clot (epidural hematoma) and brain herniation. One surgery removes the clot and a piece of skull to relieve pressure; the other removes the clot without removing skull bone. Th…

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This study tests whether a hormone called pregnenolone can improve mental health, thinking, and pain in veterans who had a mild traumatic brain injury (TBI) while serving after 9/11. About 108 veterans will take either pregnenolone or a placebo daily for 8 weeks. Researchers will…

This study tests whether a 3-week outpatient rehab program can reduce long-lasting symptoms of traumatic brain injury (TBI) and related conditions like PTSD and depression in 416 veterans and first responders. Participants will complete surveys, and some will also give blood samp…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This small pilot study is testing whether walking on a treadmill with virtual reality feedback can help people with traumatic brain injury improve their balance, reduce fear of falling, and lower fall risk. The study involves 20 adults aged 18 to 90 who have had a TBI at least on…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Participants use a special light box each morning, and researchers track changes in sleep quality, mood, thinking, and blood markers. The goal is to find…

This study tests a gentle brain stimulation method called tDCS in 41 veterans who had a mild traumatic brain injury over a year ago. Participants receive either real or fake stimulation while doing memory exercises. The goal is to see if tDCS can improve thinking skills and daily…

This study tests a new type of magnetic brain stimulation in 15 adults who have had a mild traumatic brain injury and still have symptoms like headaches or trouble thinking. Participants get 30 short treatment sessions and detailed MRI scans before and after. The goal is to see i…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study follows 300 people who had a traumatic brain injury (TBI) for at least two years after their injury. Researchers want to see how their recovery changes over time and test a blood marker that may show brain damage. The goal is to better understand the long-term effects …

This study follows 300 people who had a traumatic brain injury (TBI) to learn more about the long-term risk of developing epilepsy. Researchers will use interviews, brain scans, blood tests, and EEGs to track changes over time. The goal is to better understand how and why epileps…

This study looks at how different levels of traumatic brain injury (TBI) affect children's thinking, balance, and ability to do everyday tasks. Researchers will test 48 children aged 8 to 12 with mild to moderate TBI using standard assessments. The goal is to understand the links…

This study was designed to test a program that helps caregivers of people with traumatic brain injury improve their problem-solving skills. It planned to enroll adults aged 19 and older, but was withdrawn before any participants joined, so no results are available.

This study tests a program called BETTER that helps adults with traumatic brain injury and their families after they leave the hospital. The program provides education, training, and therapy to support recovery at home. Researchers will compare the program to usual care in 500 pa…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study tests a new behavioral therapy designed to help veterans with traumatic brain injury (TBI) improve their storytelling and everyday communication. The therapy focuses on both story content and organization. The trial includes 34 veterans and aims to see if the treatment…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study follows 1,500 older adults (65+) who come to the emergency department after a traumatic brain injury, along with matched controls. Researchers will track their recovery over 12 months using brain scans, blood tests, and health assessments. The goal is to develop age-ap…

This study tests a program to help people with traumatic brain injury (TBI) who are leaving prison avoid returning to jail. 102 participants will be randomly assigned to either the new program or standard services. The program provides support and teaches coping skills to reduce …

This study tests a 12-session teletherapy program called ICARE for people with traumatic brain injury (TBI) and their care partners. The program teaches emotion recognition from facial expressions and empathy skills through role-playing. Researchers want to see if it's practical …

This study looks at children aged 3 to 16 with severe head injuries to understand why some have poor outcomes. Researchers are testing extra monitors that track oxygen and chemical changes in the brain, which are already used safely in adults. The goal is to gather information th…