TRAUMATIC BRAIN INJURY

This early study tests whether a hormone called hCG (Ovidrel) can help men recover thinking and daily living skills after a moderate to severe traumatic brain injury. Fifty men will receive either the hormone or a placebo twice a week for 24 weeks. The main goal is to check safet…

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This study tests whether a device that gently stimulates a nerve in the ear can reduce brain damage and inflammation after a traumatic brain injury or bleeding stroke. Sixty adults will be randomly assigned to receive either real stimulation or a sham (fake) treatment. Researcher…

This study tests whether a sodium lactate infusion is safe for people with severe traumatic brain injury in the ICU. Researchers will monitor side effects and survival in 264 adults. The goal is to see if this approach is safe enough to study further.

This study tests whether setting a personalized 'optimal' blood pressure for each patient with severe traumatic brain injury reduces brain damage compared to standard fixed targets. Researchers will enroll 60 adults in the ICU and measure brain injury markers in the blood over fi…

This study tests whether a 5-day course of the steroid methylprednisolone can improve long-term recovery in adults with moderate to severe traumatic brain injury. 520 participants will receive either the drug or a placebo, added to standard care. Researchers will measure neurolog…

This study will test a device called Delphi-MD that uses magnetic pulses and brain wave recordings to diagnose traumatic brain injury (TBI). Researchers will compare results from 215 people with TBI to healthy controls, looking for patterns that could help identify and assess bra…

This study tests a portable device that uses near-infrared light to find brain bleeds in people with traumatic brain injury. The goal is to see if it works as well as a CT scan, especially in places like battlefields or rural areas where CT machines aren't available. About 80 adu…

This study looks at whether three bedside ultrasound techniques—TCCD, ONSD, and ODH—can accurately detect high pressure inside the skull (intracranial hypertension) in people with traumatic brain injury. Researchers will compare these non-invasive methods to the standard invasive…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether giving anti-epileptic drugs right after a traumatic brain injury can prevent seizures. About 70 adults with moderate to severe head injuries will receive either the drug or standard care. Researchers will track seizure episodes and recovery over 3 months …

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and problem-solving in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personalized …

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests a stepped-care version of Parent-Child Interaction Therapy (PCIT) for children aged 2 to 7 who have a mild to moderate traumatic brain injury and behavior problems. The program teaches parents positive parenting skills through online modules and weekly therapist …

This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

This study tests a wearable ankle robot designed for early rehabilitation in patients with traumatic brain injury. The robot guides motor relearning and provides passive or active movement training, even for paralyzed patients. Researchers will measure improvements in ankle movem…

This study will test whether a mild electrical stimulation applied to the lower back, combined with walking exercises, can improve mobility and balance in people with traumatic brain injury (TBI) who have weakness on one side. Thirty adults with a non-penetrating TBI at least two…

This study aims to see if special MRI scans can help predict how well people recover from moderate to severe traumatic brain injury (TBI). Researchers will scan 100 adults aged 18 to 60 soon after their injury and then check their recovery one year later. The goal is to find brai…

This study will collect blood samples, brain scans, and medical information from 270 people with penetrating brain injuries. The goal is to create a large research database that scientists can use to better understand these injuries and improve future treatments. Participants mus…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study will test whether playing selected music through headphones can help people in a coma after a severe traumatic brain injury recover cognitive function. Researchers will compare 35 patients who receive music therapy to similar patients from the past who did not. They wi…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This early-stage study tests whether a device that gently stimulates a nerve in the ear is safe and practical for people with moderate to severe traumatic brain injury. Sixteen adults will receive either real or sham stimulation while in the hospital. The main goal is to see if t…

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study will follow 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will not give any treatment but will track safety, brain function, and quality of life for 12 months. The goal is to gather real…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study looks at whether a steroid called dexamethasone can improve recovery in people with traumatic brain injury who develop brain swelling. Researchers will follow 280 adults aged 18 to 70 who already receive this treatment as part of their care, comparing their outcomes to…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better in the ICU. 216 adults will be split into three groups, each receiving a different protein dose through a feeding tube. The main goal is …

This study tests whether gentle, non-invasive brain stimulation can help people with traumatic brain injury (TBI) remember locations better. Participants will use a virtual reality game to find objects while their brain is stimulated or not. The goal is to see if stimulation impr…

This study will enroll 50 people with severe brain injuries to see if combining different types of monitoring—like blood sugar levels, brain waves, and blood flow—can help predict how well they will recover. Researchers will follow participants for 6 months to check their neurolo…

This study tests whether a hand rehabilitation device called ReHandyBot, paired with a smartphone app called RehabCoach, can help people recover after a stroke, traumatic brain injury, or orthopedic problem. Thirty participants will first use the device under supervision at a cli…