Massive kidney study aims to uncover hidden heart risks

NCT ID NCT00304148

Ongoing Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This long-term study follows over 5,000 people with chronic kidney disease to learn how the condition affects the heart and blood vessels. Researchers are tracking kidney function, heart events like heart attacks and strokes, and various risk factors. The goal is to find better ways to predict and prevent complications in people with kidney disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify key risk factors and early markers for kidney disease progression and heart problems, guiding future prevention and treatment strategies.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may take years to translate into practical medical advice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL INSUFFICIENCY CHRONIC

Contacts and locations

Locations

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Johns Hopkins Medical Institutions

Baltimore, Maryland, 21205, United States
Kaiser Permanente of Northern California

Oakland, California, 94612, United States
Metrohealth Medical Center

Cleveland, Ohio, 44109, United States
Tulane University Health Sciences Center

New Orleans, Louisiana, 70112, United States
University Hospitals of Cleveland

Cleveland, Ohio, 44106, United States
University of California

San Francisco, California, 94143-0532, United States
University of Illinois at Chicago

Chicago, Illinois, 60612, United States
University of Maryland Medical System

Baltimore, Maryland, 21201, United States
University of Michigan Hospitals

Ann Arbor, Michigan, 48106, United States
University of Pennsylvania Medical Center

Philadelphia, Pennsylvania, 19104, United States
Wayne State - Harper University Hospital

Detroit, Michigan, 48201, United States

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