Experimental trio therapy takes on recurrent glioblastoma
NCT ID NCT04225039
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether combining two immunotherapy drugs (INCAGN1876 and INCMGA00012) with targeted radiation can help people with recurrent glioblastoma, an aggressive brain cancer. The 39 participants receive the drugs before and after surgery to remove the tumor, plus radiation over three days. The goal is to see if the treatment shrinks tumors and improves survival, while monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- INCAGN1876 (immune-stimulating antibody), INCMGA00012 (PD-1 inhibitor), and stereotactic radiosurgery (focused radiation)
- What this could lead to
- If successful, this combination could offer a new treatment option for recurrent glioblastoma, potentially slowing tumor growth and extending survival.
- What could go wrong
- This is a small, early-phase trial (39 participants) with no control group, so results may not be definitive. The treatment involves strong immune drugs and radiation, which can cause serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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