Experimental Cell-Drug combo takes on tough leukemia
NCT ID NCT06768476
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial is testing whether a new immune cell therapy called CART123, given together with the drug ruxolitinib, is safe for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The study will enroll 12 adults who have no other curative options. Participants receive a single infusion of CART123 cells after a short course of ruxolitinib and chemotherapy. The main goal is to check for side effects and see if the combination is feasible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CART123 cells (a type of immune cell therapy) and ruxolitinib (a drug)
What this could lead to
If this works, it could point toward a new treatment option for people with hard-to-treat AML that has not responded to standard therapies.
What could go wrong
This is a very early, small Phase 1 trial focused on safety, not effectiveness. The combination may cause serious side effects or fail to control the leukemia.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States