New drug cocktail aims to tackle tough leukemia

NCT ID NCT05735184

Recruiting now Disease control Sponsor: Kura Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing an experimental drug called ziftomenib alongside standard treatments for acute myeloid leukemia (AML) in people with specific gene mutations. About 420 participants with newly diagnosed or relapsed AML will be assigned to one of three treatment arms. The main goals are to check safety and see if the combination helps achieve remission.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ziftomenib (investigational drug) combined with standard AML drugs (venetoclax, azacitidine, cytarabine, daunorubicin, quizartinib)
What this could lead to: If successful, this could point toward a new treatment option for acute myeloid leukemia patients with certain genetic changes.
What could go wrong: This is an early Phase 1 trial, so safety and dosing are still being tested. It may not work as hoped, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia acute myeloid leukemia with mutated NPM1 acute myeloid leukemia, MLL gene rearrangement early-onset generalized dystonia hematopoietic and lymphoid system neoplasm leukemia myeloid sarcoma refractory hematologic cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA ACUTE MYELOID LEUKEMIA RECURRENT ACUTE MYELOID LEUKEMIA, IN RELAPSE AML WITH MUTATED NPM1 KMT2AR MIXED LINEAGE LEUKEMIA GENE MUTATION MYELOID SARCOMA NPM1 MUTATION NUCLEOPHOSMIN 1-MUTATED ACUTE MYELOID LEUKEMIA REFRACTORY AML

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Cleveland Clinic Taussig Cancer Institute
RECRUITING

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Duke Blood Cancer Center
RECRUITING

Durham, North Carolina, 27705, United States
Emory Healthcare - The Emory Clinic
RECRUITING

Atlanta, Georgia, 30308, United States
Georgia Cancer Center at Augusta University
RECRUITING

Augusta, Georgia, 30912, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Johns Hopkins School of Medicine
RECRUITING

Baltimore, Maryland, 21205, United States
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic - Phoenix
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin Cancer Center
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Moores UC San Diego Cancer Center
RECRUITING

La Jolla, California, 92093, United States
Mount Sinai - Ruttenberg Treatment Center
RECRUITING

New York, New York, 10029, United States
New York - Presbyterian / Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Norton Cancer Institute - St. Matthews
RECRUITING

Louisville, Kentucky, 40207, United States
OU Health Stephenson Cancer Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Ochsner MD Anderson Cancer Center
RECRUITING

Jefferson, Louisiana, 70121, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14203, United States
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08903, United States
Sarah Cannon Research Institute - St. David's South Austin Medical Center / Texas Oncology South Austin
RECRUITING

Austin, Texas, 78704, United States
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
The James Cancer Hospital and Solove Research Institute
RECRUITING

Columbus, Ohio, 43210, United States
The University of Kansas Medical Center Research Institute
RECRUITING

Fairway, Kansas, 66205, United States
TriStar Bone Marrow Transplant
RECRUITING

Nashville, Tennessee, 37203, United States
UC Irvine Health Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCLA - Bowyer Oncology Center
RECRUITING

Los Angeles, California, 90095, United States
UMass Chan Medical School
RECRUITING

Worcester, Massachusetts, 01655, United States

Contact Email: •••••@•••••
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwestern - Simmons Cancer Center
RECRUITING

Dallas, Texas, 75235, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky Markey Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
University of Michigan Comprehensive Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Wisconsin Hospital and Clinics
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
Yale Cancer Center and Smilow Cancer Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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