University Of Pennsylvania

This study looked at whether different medications for opioid use disorder (methadone, buprenorphine/naloxone, or naltrexone) could reduce immune system inflammation in people with HIV. Researchers measured changes in blood markers of immune activation over 24 weeks. The trial wa…

This early-phase study tested a treatment called huCART-meso cells, which are a patient's own immune cells modified to recognize and attack pancreatic cancer cells. The trial included 54 people with advanced pancreatic cancer that could not be removed by surgery. The main goal wa…

This study tested whether adding an Impella CP heart pump early to standard VA-ECMO support helps people recover from cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The trial planned to enroll adults with severe heart failure but was term…

This early-phase study tested a new treatment for children and young adults with acute myeloid leukemia (AML) that returned or didn't respond to standard therapy. The treatment involved taking patients' own immune cells, engineering them to recognize and attack leukemia cells (CA…

This study tested whether a special laser (Er,Cr:YSGG) can kill bacteria in root canals better than the standard rinse. 56 adults undergoing root canal treatment had their canals cleaned with either the laser or standard sodium hypochlorite. Researchers measured bacterial levels …

This early-phase study tested a new drug called tasquinimod, alone or with standard chemotherapy, in 30 adults with multiple myeloma that had relapsed or become resistant. The main goal was to find a safe dose and check for side effects. The trial was terminated early, so results…

This study tested a special PET/CT scan using a radioactive tracer called FES to see estrogen receptor activity in women with advanced, hormone-resistant breast cancer. The goal was to see if the scan could predict how well a new hormone therapy would work. Only 6 people were enr…

This study tested whether a special oral care routine (dental cleaning and mouth treatment) could reduce severe mouth sores in people getting radiation for head and neck cancer. About 60 adults were planned to join, but the study was stopped early. The goal was to see if this app…

This study looked at why some women with breast cancer in Botswana stop taking tamoxifen, a key hormone therapy. Researchers focused on side effects, quality of life, and HIV status. The study was terminated early and only enrolled 10 participants, so findings are limited.

This study tested whether a special type of brain scan (resting state fMRI) could help doctors better understand and predict recovery in patients with disorders of consciousness, such as coma. Nine adults with these conditions were enrolled. The goal was to see if the scans could…