University Of Pennsylvania

This early-stage study tested a drug called tasquinimod, both by itself and combined with standard myeloma medications, in people whose multiple myeloma had returned or stopped responding to treatment. The main goals were to find the highest safe dose and to get a first look at w…

This study tested if adding a small heart pump (Impella CP) to a standard life-support machine (VA-ECMO) helps people with severe cardiogenic shock. The goal was to see if this combined approach helps the heart rest and recover better, allowing patients to survive without needing…

This early-phase study tested the safety of a new cell therapy called huCART-meso cells in adults with advanced pancreatic cancer that could not be removed by surgery. The therapy involves collecting a patient's own immune cells (T-cells), modifying them in a lab to better target…

This early-phase study tested a new cell therapy called CART123 in children and young adults (ages 1-29) whose acute myeloid leukemia (AML) had returned or did not respond to standard treatments. Doctors collected and genetically modified the patient's own immune cells (T cells) …

This study tested if adding a special laser to the standard cleaning process during a root canal could kill more bacteria and lead to better long-term results. 56 adults needing a routine root canal were randomly assigned to receive either the standard cleaning solution or the st…

This study tested a new type of brain scan to see if it could better assess brain activity and predict recovery in patients with severe disorders of consciousness, like coma. Researchers aimed to see if this advanced scan could provide more reliable information than current bedsi…

This study tested whether a special weekly dental cleaning and gum treatment could reduce severe mouth sores in people receiving radiation or chemotherapy for head and neck cancer. About 60 participants were randomly assigned to receive either this special cleaning protocol or st…

This study aimed to understand why women in Botswana with breast cancer might not take their tamoxifen medication as prescribed. It focused on women, including those also living with HIV, to learn how side effects, quality of life, and genetics might affect their ability to stick…