Laser zaps root canal bacteria in new study

NCT ID NCT05959629

Terminated Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a special laser (Er,Cr:YSGG) can kill bacteria in root canals better than the standard rinse. 56 adults undergoing root canal treatment had their canals cleaned with either the laser or standard sodium hypochlorite. Researchers measured bacterial levels before and after treatment and also checked pain levels. The study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Er,Cr:YSGG laser (Waterlase Express™)
What this could lead to: If successful, this laser method could become a new option to disinfect root canals, potentially reducing infection and pain after treatment.
What could go wrong: This was a small, early study that was terminated, so results are limited. The laser may not work better than standard care, and its effectiveness is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dental abscess dental pulp disorder suppurative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDODONTIC DISEASE ROOT CANAL INFECTION

Contacts and locations

Locations

University of Pennsylvania, School of Dental Medicine

Philadelphia, Pennsylvania, 19104, United States

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