University Of Pennsylvania

This study aims to find the best personalized sequence of simple dental treatments to prevent cavities in schoolchildren. It will test different combinations of minimally invasive procedures on 1,200 kids aged 5-13 in schools. The goal is to reduce the number of children whose ca…

This study is testing if starting a breathing machine, called non-invasive ventilation (NIV), earlier than the current standard can help people with ALS. Researchers will use a prediction tool to identify patients at higher risk for breathing problems and randomly assign them to …

This early-stage study is testing a new two-part treatment for adults with aggressive blood cancers that have come back or not responded to other therapies. Doctors will first give patients a transplant of their own genetically edited stem cells, followed by an infusion of their …

This pilot study is testing a smart sharps disposal container for people with hemophilia who give themselves preventive medication injections at home. The goal is to see if patients find the container easy to use and stick with using it, and to check if their doctors are satisfie…

This study is testing if providing monthly cash payments helps people recently released from prison. About 450 adults in Nebraska will either receive payments for a year or be in a comparison group. Researchers will track if the money improves housing, health, finances, and reduc…

This study is testing whether a single dose of a nutritional ketone supplement can affect how the brain uses energy and influence drinking behavior in people with mild to moderate alcohol use disorder. Participants will receive the supplement or a placebo and then have brain scan…

This is an early safety study testing a new type of modified immune cell therapy for adults whose follicular lymphoma has returned or not responded to prior treatments. The main goals are to see if the treatment is safe to give and if researchers can successfully track where thes…

This study aims to see if taking low-dose aspirin at a specific time of day can prevent a common pain reliever (celecoxib) from raising blood pressure. It will involve 60 healthy adults who are known to have their blood pressure go up when taking celecoxib. Researchers will test …

This study is testing whether adding a special liquid nutrition formula to standard Crohn's disease medication helps patients get better faster. 80 adults with active Crohn's disease will choose to either take their new medication alone or add the liquid nutrition. Researchers wi…

This study is developing and testing a telehealth program designed to make treatment for opioid addiction more accessible, especially for underserved groups. It will involve 60 participants, some already in treatment and some just starting, to see if remote care can help people s…

This study is testing a faster MRI scanning technique designed to create images of blood vessel walls. Researchers want to see if this quicker method can produce images that are just as clear and useful for diagnosis as the standard, longer scans. The study involves 15 adults who…

This study aims to see if a new community-based telehealth model can help more people get access to PrEP, a daily pill that prevents HIV. Researchers will partner with local community organizations to offer telehealth navigation for PrEP and compare it to the standard online sign…

This study tests whether a brief, nurse-led conversation about safe gun storage with parents of hospitalized children can prevent firearm injuries and deaths. Nurses will talk to parents about locking up firearms and offer a free cable lock. Researchers want to see if this progra…

This study is testing whether the antidepressant medication duloxetine can help reduce psychological distress and improve daily functioning in adults with inflammatory bowel disease (IBD). Thirty-two participants with elevated anxiety, depression, or IBD-related disability will t…

This study is testing whether a 12-week, home-based exercise program is safe, practical, and helpful for adults aged 60 and older who are on the waiting list for a kidney transplant. Researchers will compare a group doing online exercise classes to a group receiving usual care, b…

This study is testing which of two standard anesthesia approaches works better to prevent PTSD in women who experience severe pain during cesarean sections. Researchers will compare early general anesthesia (full unconsciousness) versus intravenous sedation for women whose pain d…

This study is testing if using brain scan images to program a deep brain stimulation (DBS) device works better than the standard method to reduce hand tremors. Twenty adults with essential tremor who already have a specific DBS device will try both programming methods. Researcher…

This study is for people with hypothyroidism who still feel tired and unwell despite having normal blood test results on their current medication. It will test if adding a second thyroid hormone (T3) to the standard treatment (T4) for six months improves quality of life, energy, …

This large study aims to find the best way to provide palliative care—specialized medical care focused on relieving suffering and improving quality of life—for seriously ill hospital patients. Researchers will compare three approaches across 48 hospitals: standard care, training …

This study aims to understand how ketamine works to rapidly improve depression symptoms. Researchers will use a special brain imaging technique to measure chemical changes in the brains of 10 adults with treatment-resistant depression before and after they receive a single ketami…

This study aims to understand how magnetic stimulation of a specific brain area affects anxiety. Researchers will use brain scans and anxiety tests on 140 people with high anxiety to see how stimulation changes brain activity and anxiety responses. The goal is to gather evidence …

This study aims to understand how common stressors like sleep loss and alcohol affect brain function and coordination. Up to 56 healthy adults will spend about six days in a lab, where they will be kept awake for 27 hours and drink alcohol on a separate day to measure their react…

This study is testing a smartphone app designed to help school aides who work one-on-one with children. The goal is to see if the app helps aides collect more consistent and timely information about a child's behavior and skills. Researchers will compare the app to a simpler data…

This study will test whether providing a guaranteed income payment (a 'negative income tax') helps community college students in Omaha complete their degrees or certificates and get jobs in their field. Researchers will enroll 750 low-income students and randomly assign some to r…

This study aims to collect long-term follow-up information from people who previously took part in a dry eye research study. Researchers will gather samples like tears, saliva, and blood, and perform eye and mouth exams to better understand how dry eye and Sjögren's syndrome deve…

This study is testing whether a personalized video education platform helps stroke survivors and their caregivers. Researchers want to see if the videos improve understanding of stroke and reduce trips back to the hospital or doctor after going home. About 690 people will be rand…

This is a small pilot study to see if a special non-invasive monitor can work reliably during continuous dialysis for critically ill patients. The monitor checks blood levels and oxygen during treatment. Researchers want to know if the readings stay accurate over long periods and…

This study is testing whether a new text-based AI platform can successfully recruit and connect pregnant people in Philadelphia to early care and information. The main goal is to see if enough people sign up through the texting service. Researchers will also check if participants…

This early study aims to understand if lowering 'bad' cholesterol with injections of the drug evolocumab changes the tissue and cells of an abdominal aortic aneurysm. Researchers will compare 44 patients scheduled for open aneurysm repair, giving half the drug and half a placebo …

This study aims to understand how brain energy use changes in Alzheimer's disease and whether a ketogenic dietary supplement can improve it. Researchers will use combined PET and MRI scans to measure how the brain uses glucose and oxygen in 17 participants, including both healthy…

This study aims to find the best way to measure levels of a body chemical called NAD+ in healthy people. Researchers will check NAD+ levels in the blood, urine, and muscles of 48 healthy adults before and after they take an over-the-counter supplement for 30 days. The goal is to …