University Of Pennsylvania

This phase 1 trial tests a radioactive drug called 211At-MABG in 16 adults with advanced neuroendocrine cancers, including pheochromocytoma and paraganglioma. The drug delivers radiation directly to cancer cells that show up on a special scan. The main goal is to see if the treat…

This pilot study will develop and test a telehealth program designed to help marginalized patients access and stay in treatment for opioid use disorder. Researchers will enroll 60 people—half already in treatment and half not yet in treatment—and provide them with a user-friendly…

This early-phase trial tests a new type of cell therapy called TCR1188-ABC for people with certain advanced cancers (pancreatic, colorectal, lung, or bile duct) that have a specific KRAS G12V mutation. The treatment involves taking a patient's own immune cells, engineering them t…

This study tests whether giving people leaving prison a monthly cash payment ($1,000 for the first month, then $750 for 11 months) helps them stay healthy, find stable housing, avoid going back to jail, and manage their finances. Researchers will follow 450 adults in Nebraska for…

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure h…

This study looks at the best time interval between two medications, mifepristone and misoprostol, for managing early pregnancy loss. Researchers will follow 1,000 participants to see which timing leads to the highest success rate with fewer side effects. The goal is to improve tr…

This study tests different sequences of minimally invasive dental treatments—like silver diamine fluoride, sealants, and fluoride varnish—plus a hygiene program, to see which works best for children aged 5 to 13 in schools. The goal is to reduce the number of kids who don't respo…

This study looks at whether adding a special liquid diet (partial enteral nutrition) to standard medication helps people with active Crohn's disease achieve remission without steroids. About 80 participants will choose to either add the diet or not. The main goal is to see if mor…

This study tests a new AI tool called INTERLACE that helps doctors diagnose older adults during primary care visits. The AI uses a patient's medical history, vital signs, and symptoms to suggest possible diagnoses and tests. Researchers want to see if the tool is easy to use and …

This study tests whether sending text reminders to patients who are overdue for colorectal cancer screening helps them follow through and get a colonoscopy or stool test. About 3,888 adults with a scheduled primary care visit will take part. The goal is to make it easier for peop…

This study tests a program where nurses talk to parents of hospitalized children about safely storing firearms and offer free cable locks. The goal is to see if this brief conversation changes how parents store guns at home, potentially preventing accidental shootings and suicide…

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study tests whether duloxetine, a medication that affects brain signals, can reduce disability and psychological distress in adults with inflammatory bowel disease (IBD). About 32 participants will take duloxetine for a period, and researchers will measure changes in anxiety…

This study tests whether adding a second thyroid hormone (T3) to the standard T4 treatment can improve persistent symptoms like fatigue and brain fog in people with hypothyroidism. It involves 60 adults aged 18-70 who still have symptoms despite normal thyroid blood tests. Partic…

This study tests a botulinum toxin called DaxibotulinumtoxinA (DAXI) for adults with blepharospasm, a condition causing uncontrollable blinking or eye muscle spasms. Twenty participants will receive up to three injection cycles over 12 months. The goal is to measure how long symp…

This early-stage study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. The goal is to see if NaPB might help ease vascular problems linked to diabetes.

This study tests whether using brain images to program deep brain stimulation (DBS) devices works better than the usual method for reducing hand tremors in people with essential tremor. Twenty adults who already have DBS electrodes in their brain will try both programming approac…

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This study tests whether sending text reminders to both doctors and patients can increase the number of people who complete overdue health screenings, such as mammograms, diabetes checks, and hepatitis C tests. About 16,400 adults with an upcoming primary care visit will take par…

This study aims to see if magnetic resonance spectroscopy (MRS) can accurately measure NAD+ levels in the brain and calf muscles of healthy adults. Participants will take an over-the-counter nicotinamide riboside (NR) supplement, and researchers will compare NAD+ measurements bef…

This early-phase study tests whether taking a low-dose aspirin in the evening can offset the blood pressure increases caused by the pain reliever celecoxib. Researchers will monitor blood pressure in 60 healthy adults over several weeks. The goal is to learn if timing matters for…

This study looks at whether digital tools like chatbots, games, and videos can help parents in Nigeria decide to vaccinate their daughters against HPV, a virus that can cause cervical cancer. About 3,340 parents of unvaccinated girls aged 9-14 will be randomly assigned to try one…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This study tests whether a type of magnetic brain stimulation called aiTBS can change brain wave patterns and improve performance on thinking tasks. About 80 healthy adults will receive stimulation over three days while their brain activity is recorded with EEG. The goal is to un…

This study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find th…

This study tests a smart sharps disposal container that helps hemophilia patients safely throw away used needles at home. About 23 adults with moderate or severe hemophilia will use the device for several weeks. Researchers want to see if patients find it easy to use and if they …

This study tests whether evolocumab, a drug that lowers 'bad' cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will receive either the drug or a placebo before surgery. Researchers will then compare the tiss…

This study tests whether giving low-income community college students extra money (a negative income tax) helps them finish their degree or certificate and find better jobs. About 750 students in Omaha will be randomly chosen to receive the extra money or not. Researchers will tr…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will …

This study tests whether a personalized video platform called MyStroke can improve stroke knowledge and reduce hospital use after discharge. About 690 stroke patients and their caregivers will either get standard education or also access to tailored videos. Researchers will check…

This study will put 56 healthy adults aged 25-60 through 27 hours of sleep deprivation and alcohol consumption (to a 0.08% BAC) in a lab over 110 hours. Researchers will measure how these stressors affect thinking, movement, and brain scans. The goal is to better predict and mana…

This study will use combined PET and MRI scans to measure how the brain uses glucose and oxygen in healthy adults and people with Alzheimer's disease. Researchers want to see if a commercially available ketone drink can improve brain energy metabolism. The study involves 17 parti…