Night shift Workers' gut bugs under the microscope

NCT ID NCT03221517

Ongoing Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how working night shifts changes the bacteria in your gut and how your body handles sugar. Researchers will compare 12 healthy men who work night shifts with those who work during the day. They will track gut bacteria and blood sugar levels at different times of day to understand why shift workers have higher disease risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Standardized meal with glucose challenge test
What this could lead to: If successful, this could reveal how shift work disrupts gut bacteria, pointing toward ways to reduce disease risk in shift workers.
What could go wrong: This is a very small, early observational study with only 12 participants, so findings may not apply broadly. It does not test any treatment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine

Philadelphia, Pennsylvania, 19104, United States

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