Simple blood test may forecast bone healing

NCT ID NCT06872775

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether RNA molecules in the blood can predict if a broken bone will heal normally, slowly, or not at all. Researchers will collect blood samples from 110 people with fractures at several time points after injury and compare the RNA test results to actual healing outcomes over 270 days. The goal is to develop a tool that helps doctors identify healing problems early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test that helps doctors predict whether a broken bone will heal normally or need extra treatment.
What could go wrong: This is an early observational study, not a treatment trial. The RNA test may not prove accurate enough for routine use, and results may not apply to all types of fractures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bone fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRACTURES, BONE

Contacts and locations

Locations

Indiana University

Bloomington, Indiana, 47401-3654, United States
University of California, Davis Medical Center

Sacramento, California, 95817, United States
University of Missouri

Columbia, Missouri, 65211-0001, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Texas Health Science Center at Houston

Houston, Texas, 77030-5400, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences/Advocate Health

Charlotte, North Carolina, 28203, United States

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