New stroke trial aims to restore blood flow in tiny brain vessels
NCT ID NCT06904911
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal can improve blood flow in tiny vessels. About 20 adults who had a major stroke from a large clot will receive a single dose of the drug through a catheter. Researchers will measure changes in blood flow using special imaging and track recovery over 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tenecteplase (a clot-busting drug given directly into the brain artery)
What this could lead to
If it works, this could point toward a way to improve recovery after a major stroke by restoring blood flow in tiny brain vessels that standard treatment misses.
What could go wrong
This is a very small, early-phase trial with only 20 participants and no comparison group, so results may not hold up in larger studies. The drug also carries a risk of bleeding in the brain.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••