New stroke trial aims to restore blood flow in tiny brain vessels

NCT ID NCT06904911

Recruiting now Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal can improve blood flow in tiny vessels. About 20 adults who had a major stroke from a large clot will receive a single dose of the drug through a catheter. Researchers will measure changes in blood flow using special imaging and track recovery over 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tenecteplase (a clot-busting drug given directly into the brain artery)
What this could lead to: If it works, this could point toward a way to improve recovery after a major stroke by restoring blood flow in tiny brain vessels that standard treatment misses.
What could go wrong: This is a very small, early-phase trial with only 20 participants and no comparison group, so results may not hold up in larger studies. The drug also carries a risk of bleeding in the brain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE FROM LARGE VESSEL OCCLUSION

Contacts and locations

Locations

Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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