New ALS drug candidate QRL-101 tested in small safety trial
NCT ID NCT06714396
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 1 study tested a single dose of the experimental drug QRL-101 in 12 people with ALS. The main goals were to see how the drug moves through the body and whether it is safe. Participants received either QRL-101 or a placebo, and researchers monitored side effects and drug levels in the blood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
QRL-101
What this could lead to
If this early study shows QRL-101 is safe and well-tolerated, it could support larger trials to see if it helps control ALS progression.
What could go wrong
This is a very small, early-phase trial with only 12 participants. It is designed mainly to check safety and drug levels, not to prove the drug works for ALS. Many drugs fail in later stages.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Universitair Medisch Centrum Utrecht
Utrecht, Netherlands, 9728 NZ, Netherlands