AMYOTROPHIC LATERAL SCLEROSIS
Clinical trials for AMYOTROPHIC LATERAL SCLEROSIS explained in plain language.
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Early ALS drug trial halted after safety check
Disease control TerminatedThis early-stage study aimed to check the safety and side effects of an oral drug called DNL747 in people with ALS (Lou Gehrig's disease). It involved 15 participants who took the drug or a placebo in a crossover design. The main goal was to see how the body processes the drug an…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS
Phase: PHASE1 • Sponsor: Sanofi • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Halted trial tests new shot at slowing devastating ALS
Disease control TerminatedThis study tested an experimental drug called BIIB105 in adults with ALS (amyotrophic lateral sclerosis). The drug was designed to lower levels of a protein linked to the disease and was given via spinal injection. The main goals were to check the drug's safety and see if it coul…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS
Phase: PHASE1, PHASE2 • Sponsor: Biogen • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Early ALS drug trial halted: safety first in fight against nerve disease
Disease control TerminatedThis early-stage study aimed to test the safety and side effects of an experimental drug called VRG50635 in people with ALS (Lou Gehrig's disease). It involved 54 adults with ALS to see how their bodies handled increasing doses of the drug over time and to look for early signs it…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS
Phase: PHASE1 • Sponsor: Verge Genomics • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Personalized stem cell shot tested to fight ALS
Disease control TerminatedThis study tested whether a treatment made from a patient's own bone marrow stem cells (called STR04) could help control Amyotrophic Lateral Sclerosis (ALS). The goal was to see if four intravenous doses could slow the decline in muscle function and breathing. The trial was termi…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS
Phase: PHASE2 • Sponsor: New England Cell Therapeutics, Inc. • Aim: Disease control
Last updated Mar 19, 2026 14:56 UTC
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Scientists scan brains to see if new drug calms ALS inflammation
Knowledge-focused TerminatedThis study tested an experimental drug called BLZ945 in people with ALS (amyotrophic lateral sclerosis). The main goal was to see if the drug could safely reduce inflammation from specific brain cells (microglia) and to find the right dose. Researchers used special brain scans (P…
Matched conditions: AMYOTROPHIC LATERAL SCLEROSIS
Phase: PHASE2 • Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:27 UTC