ALS drug trial halted early: did lithium fail?
NCT ID NCT06008249
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tested lithium carbonate against placebo in 88 people with ALS to see if it could improve survival and daily function. The study was terminated early, so the full results are not available. The trial aimed to find a treatment that slows the disease, but its early end limits what we can learn.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lithium carbonate
What this could lead to
If successful, this could point toward a treatment that slows ALS progression and extends survival.
What could go wrong
The trial was terminated early with only 88 participants, so results are limited. Lithium has known side effects and may not work for all ALS patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bellvitge University Hospital
Barcelona, 08907, Spain
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Calvary Health Care Bethlehem
Parkdale, VIC 3195, Australia
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Concord hospital Sydney
Sydney, NSW 2139, Australia
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Flinders Medical Centre
Adelaide, SA 5042, Australia
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Karolinska University Hospital
Stockholm, 171 64, Sweden
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King's College Hospital
London, SE5 9RS, United Kingdom
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Perron Institute
Perth, WA 6009, Australia
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Royal Brisbane and Women's Hospital
Brisbane, QLD 4029, Australia
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The University of Sydney (Royal prince Alfred hospital)
Sydney, NSW 2050, Australia
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University College London Hospital NHS
London, WC1N 3BG, United Kingdom
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University Hospital Leuven
Leuven, 3000, Belgium
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University Hospitals of North Midlands NHS Trust
Stoke-on-Trent, ST4 6QG, United Kingdom
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University Medical Center Utrecht
Utrecht, Utrecht, 3584 CX, Netherlands