AMYOTROPHIC LATERAL SCLEROSIS

This early-stage study is testing whether an infusion made from stem cells found in baby teeth is safe and might help people with ALS. The trial involves 10 Japanese patients with mild to moderate ALS symptoms. Researchers will monitor safety closely and check if the treatment he…

This was a special access program for a single patient with ALS (Lou Gehrig's disease). The study tested whether infusions of the patient's own specially processed stem cells, given over 18 weeks, could help control the disease. Doctors closely monitored the patient's symptoms, p…

This program provided access to an experimental ALS treatment called SLS-005 for patients who couldn't join regular clinical trials. Approximately 70 participants received weekly intravenous infusions of trehalose for up to 24 weeks. The goal was to offer this investigational tre…

This study is testing an experimental drug called ION363 for people with ALS caused by specific mutations in the FUS gene. The drug is delivered via spinal injection and aims to slow the loss of physical function and improve survival. The trial will involve about 95 participants …

This trial provides access to an experimental cell therapy called RAPA-501 for people with advanced ALS who cannot join other studies. Doctors collect a patient's own immune cells, reprogram them in a lab to reduce inflammation, and infuse them back into the patient up to four ti…

This study offers extended treatment with CNM-Au8 to patients with early ALS who completed the initial trial. The goal is to continue assessing whether this experimental treatment can slow disease progression while monitoring safety. Participants receive the active treatment for …

This study is testing whether starting a home breathing machine for people with ALS (amyotrophic lateral sclerosis) from their own home is just as good as starting it during a hospital stay. Researchers are comparing the two approaches in 46 patients to see if the home-based meth…

This study is testing if a drug called acamprosate is safe and might help slow the progression of ALS (amyotrophic lateral sclerosis) in people who have a specific genetic change (C9orf72 mutation). It involves 30 participants who will take the drug for 24 weeks while researchers…

This study is testing whether a combination of two dietary supplements, Nicotinamide Riboside and Pterostilbene, can slow down the progression of ALS (Lou Gehrig's disease). The trial involves 380 people with ALS who will take either the supplement or a placebo. Researchers aim t…

This study is testing an investigational drug called ARGX-119 in adults with ALS (amyotrophic lateral sclerosis). The main goals are to check the drug's safety and see if it can help slow the loss of muscle function. About 60 participants will receive different doses of the drug …

This study is testing whether an investigational drug called NX210c can slow the progression of ALS (amyotrophic lateral sclerosis). It will involve about 80 adults with ALS who will receive either the drug or a placebo through intravenous infusions. The main goals are to see if …

This study is testing whether stem cells taken from a patient's own body fat and injected into the fluid around their spine can safely slow the progression of ALS. Over 12 months, 75 participants at Mayo Clinic will receive four injections to see if this treatment helps maintain …

This early-stage study is testing a one-time gene therapy called AMT-162 for adults with ALS caused by a specific faulty SOD1 gene. The therapy is injected into the spinal fluid and aims to 'silence' the harmful gene to slow the disease. Researchers will first check if the treatm…

This clinical trial is testing whether an experimental drug called MN-166 (ibudilast) can slow the progression of ALS (amyotrophic lateral sclerosis or Lou Gehrig's disease). The study involves 234 adults recently diagnosed with ALS, who will take either the drug or a placebo for…

This study aims to create and validate a simple set of physical tests to better predict the risk of falling for people with various nerve and muscle disorders. Researchers will test 108 patients with conditions like muscular dystrophy and ALS using tasks like standing up from a c…

This study is testing a new, more comfortable headset designed to help people with advanced ALS communicate. The device reads brain signals to let users type on a virtual keyboard without moving. Researchers are working with a small group of ALS patients to see if this prototype …

This study aims to find better ways to predict when people with ALS will develop breathing problems. Researchers will use electrical muscle tests and ultrasound scans on 80 ALS patients to see if these tools can detect early signs of respiratory decline. The goal is to help docto…

This study aims to find and validate biological markers (biomarkers) in blood, urine, and spinal fluid from people with ALS and related disorders. The goal is to better understand the diseases and create tools to measure if future experimental treatments are working. It involves …

This study aims to understand the very earliest signs of ALS in people who have been diagnosed but still have parts of their body that feel and work normally. Researchers will observe 100 participants, including people with early ALS and healthy volunteers, to learn how the disea…

This study is testing whether a smartphone app can reliably track changes in speech and swallowing for people with ALS from their own homes. Researchers want to see if this remote monitoring works well for patients and provides useful information compared to standard clinic visit…