Sound waves used to sneak medicine into brain for ALS
NCT ID NCT07193953
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests whether a special helmet that uses focused ultrasound can safely open the blood-brain barrier to deliver an anti-inflammatory drug (IVIg) directly to the motor cortex in people with ALS. Six participants will receive two doses of IVIg, with the second dose combined with the ultrasound procedure. The main goals are to check safety and see if the drug reaches its target.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Intravenous immunoglobulin (IVIg)
What this could lead to
If this works, it could show a new way to deliver treatments to the brain for ALS, potentially reducing inflammation and slowing disease progression.
What could go wrong
This is a very early phase 1 trial with only 6 people. It focuses on safety, not effectiveness. The procedure involves opening the blood-brain barrier, which carries risks like bleeding or swelling.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact