Massive ALS trial tests multiple drugs at once to find a way to slow the deadly disease

NCT ID NCT04297683

Recruiting now Disease control Sponsor: Merit E. Cudkowicz, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing several experimental treatments at the same time to see if they can slow down ALS, a disease that weakens muscles and gets worse over time. About 1,500 adults with early-stage ALS will take part. The goal is to find treatments that help people stay stronger and live longer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atrium Health
RECRUITING

Charlotte, North Carolina, 28207, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Email: •••••@•••••
Augusta University
RECRUITING

Augusta, Georgia, 30912, United States

Contact Phone: •••-•••-••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Austin Neuromuscular Clinic
RECRUITING

Austin, Texas, 78759, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States

Contact Email: •••••@•••••
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Columbia University
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Dent Neurologic Institute
RECRUITING

Amherst, New York, 14226, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Duke University
RECRUITING

Durham, North Carolina, 27702, United States

Contact Email: •••••@•••••
Essentia Health
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Forbes Norris MDA/ALS Research Center, California Pacific Medical Center
RECRUITING

San Francisco, California, 94115, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
George Washington University
RECRUITING

Washington D.C., District of Columbia, 20037, United States

Contact Email: •••••@•••••
Georgetown University
RECRUITING

Washington D.C., District of Columbia, 20007, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hospital for Special Care
RECRUITING

New Britain, Connecticut, 06053, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States

Contact Email: •••••@•••••
Indiana University Health
RECRUITING

Indianapolis, Indiana, 46202, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Jefferson Weinberg ALS Center, Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kaiser Permanente Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90027, United States

Contact Email: •••••@•••••
Lahey Hospital and Medical Center
RECRUITING

Burlington, Massachusetts, 01805, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Lehigh Valley Health Network
RECRUITING

Allentown, Pennsylvania, 18103, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Lewis Katz School of Medicine at Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Loma Linda University Health
RECRUITING

Loma Linda, California, 92354, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55902, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States

Contact Email: •••••@•••••
Mayo Clinic Scottsdale
RECRUITING

Scottsdale, Arizona, 85259, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mount Sinai
RECRUITING

New York, New York, 10003, United States

Contact Email: •••••@•••••
Neurology Associates, P.C./Somnos Clinical Research
ACTIVE_NOT_RECRUITING

Lincoln, Nebraska, 68506, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Nova Southeastern University
RECRUITING

Davie, Florida, 33024, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Ochsner Health System
ACTIVE_NOT_RECRUITING

New Orleans, Louisiana, 70115, United States
OhioHealth Research Institute
RECRUITING

Westerville, Ohio, 43082, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Penn State Hershey
RECRUITING

Hershey, Pennsylvania, 17033, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Brain and Spine Institute ALS Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
SUNY Upstate
RECRUITING

Syracuse, New York, 13202, United States

Contact Email: •••••@•••••
Saint Alphonsus Regional Medical Center
RECRUITING

Boise, Idaho, 83704, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Louis University
RECRUITING

St Louis, Missouri, 63104, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Spectrum Health/Corewell Health
RECRUITING

Grand Rapids, Michigan, 49525, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Swedish Medical Center
RECRUITING

Seattle, Washington, 98122, United States

Contact Phone: •••-•••-••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Texas Neurology
RECRUITING

Dallas, Texas, 75214, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States

Contact Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
UC San Diego
RECRUITING

La Jolla, California, 92037, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
UTHSCSA
RECRUITING

San Antonio, Texas, 78229, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of California, Irvine
RECRUITING

Orange, California, 92868, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Florida
RECRUITING

Gainesville, Florida, 32610, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Kansas Medical Center
RECRUITING

Fairway, Kansas, 66205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Massachusetts Medical School
RECRUITING

North Worcester, Massachusetts, 01655, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Email: •••••@•••••
University of Miami
ACTIVE_NOT_RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Minnesota Medical School
RECRUITING

Minneapolis, Minnesota, 55455, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Missouri Health Care
RECRUITING

Columbia, Missouri, 65212, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••

Contact Email: •••••@•••••
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Pittsburg Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Rochester
RECRUITING

Rochester, New York, 14642, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of South Florida
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Southern California
RECRUITING

Los Angeles, California, 90033, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Washington
RECRUITING

Seattle, Washington, 98195, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Virginia Commonwealth University
RECRUITING

Henrico, Virginia, 23233, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Wake Forest Health Science
RECRUITING

Winston-Salem, North Carolina, 27157, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06519, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••