Massive ALS trial tests multiple drugs at once to slow deadly nerve disease

NCT ID NCT04297683

Recruiting now Disease control Sponsor: Merit E. Cudkowicz, MD Source: ClinicalTrials.gov ↗

First seen Jan 06, 2026 · Last updated May 09, 2026 · Updated 19 times

Summary

This study is testing several experimental treatments at the same time to see if they can slow down ALS, a disease that weakens muscles and makes it hard to move, speak, and breathe. About 1,500 adults with ALS will take part. The main goal is to see if the treatments can slow the disease's progress and help people live longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atrium Health
RECRUITING

Charlotte, North Carolina, 28207, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Email: •••••@•••••
Augusta University
ACTIVE_NOT_RECRUITING

Augusta, Georgia, 30912, United States
Austin Neuromuscular Clinic
RECRUITING

Austin, Texas, 78759, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States

Contact Email: •••••@•••••
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Columbia University
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Dent Neurologic Institute
RECRUITING

Amherst, New York, 14226, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Duke University
RECRUITING

Durham, North Carolina, 27702, United States

Contact Email: •••••@•••••
Essentia Health
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Forbes Norris MDA/ALS Research Center, California Pacific Medical Center
RECRUITING

San Francisco, California, 94115, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
George Washington University
RECRUITING

Washington D.C., District of Columbia, 20037, United States

Contact Email: •••••@•••••
Georgetown University
RECRUITING

Washington D.C., District of Columbia, 20007, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hackensack University Medical Center
ACTIVE_NOT_RECRUITING

Hackensack, New Jersey, 07601, United States
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hospital for Special Care
RECRUITING

New Britain, Connecticut, 06053, United States

Contact Email: •••••@•••••
Houston Methodist
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Indiana University Health
RECRUITING

Indianapolis, Indiana, 46202, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Jefferson Weinberg ALS Center, Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Johns Hopkins University
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21205, United States
Kaiser Permanente Los Angeles Medical Center
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90027, United States
Lehigh Valley Health Network
RECRUITING

Allentown, Pennsylvania, 18103, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Lewis Katz School of Medicine at Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Loma Linda University Health
ACTIVE_NOT_RECRUITING

Loma Linda, California, 92354, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55902, United States

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Mayo Clinic Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Scottsdale
RECRUITING

Scottsdale, Arizona, 85259, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mount Sinai
RECRUITING

New York, New York, 10003, United States

Contact Email: •••••@•••••
Neurology Associates, P.C./Somnos Clinical Research
ACTIVE_NOT_RECRUITING

Lincoln, Nebraska, 68506, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Nova Southeastern University
RECRUITING

Davie, Florida, 33024, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Ochsner Health System
ACTIVE_NOT_RECRUITING

New Orleans, Louisiana, 70115, United States
OhioHealth Research Institute
RECRUITING

Westerville, Ohio, 43082, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Penn State Hershey
RECRUITING

Hershey, Pennsylvania, 17033, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Brain and Spine Institute ALS Center
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97213, United States
SUNY Upstate
RECRUITING

Syracuse, New York, 13202, United States

Contact Email: •••••@•••••
Saint Alphonsus Regional Medical Center
ACTIVE_NOT_RECRUITING

Boise, Idaho, 83704, United States
Saint Louis University
RECRUITING

St Louis, Missouri, 63104, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Spectrum Health/Corewell Health
RECRUITING

Grand Rapids, Michigan, 49525, United States

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Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States

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Swedish Medical Center
RECRUITING

Seattle, Washington, 98122, United States

Contact Phone: •••-•••-••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Texas Neurology
RECRUITING

Dallas, Texas, 75214, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States

Contact Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
UTHSCSA
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78229, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of California, Irvine
ACTIVE_NOT_RECRUITING

Orange, California, 92868, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Chicago
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Florida
ACTIVE_NOT_RECRUITING

Gainesville, Florida, 32610, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Kansas Medical Center
RECRUITING

Fairway, Kansas, 66205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Kentucky
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40536, United States
University of Massachusetts Medical School
RECRUITING

North Worcester, Massachusetts, 01655, United States

Contact Email: •••••@•••••

Contact Email: •••••@•••••
University of Miami
ACTIVE_NOT_RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Minnesota Medical School
RECRUITING

Minneapolis, Minnesota, 55455, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Missouri Health Care
RECRUITING

Columbia, Missouri, 65212, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of North Carolina
ACTIVE_NOT_RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Pittsburg Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Rochester
RECRUITING

Rochester, New York, 14642, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of South Florida
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Southern California
RECRUITING

Los Angeles, California, 90033, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States

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University of Washington
RECRUITING

Seattle, Washington, 98195, United States

Contact Phone: •••-•••-••••

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Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Virginia Commonwealth University
ACTIVE_NOT_RECRUITING

Henrico, Virginia, 23233, United States
Wake Forest Health Science
RECRUITING

Winston-Salem, North Carolina, 27157, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06519, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

AMYOTROPHIC LATERAL SCLEROSIS