Massive ALS trial tests multiple drugs at once to find a way to slow the deadly disease

NCT ID NCT04297683

Ongoing Disease control Sponsor: Merit E. Cudkowicz, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study is testing several experimental treatments at the same time to see if they can slow down ALS, a disease that weakens muscles and gets worse over time. About 1,500 adults with early-stage ALS will take part. The goal is to find treatments that help people stay stronger and live longer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

Locations

Atrium Health

Charlotte, North Carolina, 28207, United States
Augusta University

Augusta, Georgia, 30912, United States
Austin Neuromuscular Clinic

Austin, Texas, 78759, United States
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Columbia University

New York, New York, 10032, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Dent Neurologic Institute

Amherst, New York, 14226, United States
Duke University

Durham, North Carolina, 27702, United States
Essentia Health

Duluth, Minnesota, 55805, United States
Forbes Norris MDA/ALS Research Center, California Pacific Medical Center

San Francisco, California, 94115, United States
George Washington University

Washington D.C., District of Columbia, 20037, United States
Georgetown University

Washington D.C., District of Columbia, 20007, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hospital for Special Care

New Britain, Connecticut, 06053, United States
Houston Methodist

Houston, Texas, 77030, United States
Indiana University Health

Indianapolis, Indiana, 46202, United States
Jefferson Weinberg ALS Center, Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Johns Hopkins University

Baltimore, Maryland, 21205, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lehigh Valley Health Network

Allentown, Pennsylvania, 18103, United States
Lewis Katz School of Medicine at Temple University

Philadelphia, Pennsylvania, 19140, United States
Loma Linda University Health

Loma Linda, California, 92354, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55902, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic Scottsdale

Scottsdale, Arizona, 85259, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Mount Sinai

New York, New York, 10003, United States
Neurology Associates, P.C./Somnos Clinical Research

Lincoln, Nebraska, 68506, United States
Northwestern University

Chicago, Illinois, 60611, United States
Nova Southeastern University

Davie, Florida, 33024, United States
Ochsner Health System

New Orleans, Louisiana, 70115, United States
OhioHealth Research Institute

Westerville, Ohio, 43082, United States
Penn State Hershey

Hershey, Pennsylvania, 17033, United States
Providence Brain and Spine Institute ALS Center

Portland, Oregon, 97213, United States
SUNY Upstate

Syracuse, New York, 13202, United States
Saint Alphonsus Regional Medical Center

Boise, Idaho, 83704, United States
Saint Louis University

St Louis, Missouri, 63104, United States
Spectrum Health/Corewell Health

Grand Rapids, Michigan, 49525, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
Texas Neurology

Dallas, Texas, 75214, United States
The Ohio State University

Columbus, Ohio, 43221, United States
UC San Diego

La Jolla, California, 92037, United States
UTHSCSA

San Antonio, Texas, 78229, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California, Irvine

Orange, California, 92868, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Fairway, Kansas, 66205, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Massachusetts Medical School

North Worcester, Massachusetts, 01655, United States
University of Miami

Miami, Florida, 33136, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Minnesota Medical School

Minneapolis, Minnesota, 55455, United States
University of Missouri Health Care

Columbia, Missouri, 65212, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19107, United States
University of Pittsburg Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester

Rochester, New York, 14642, United States
University of South Florida

Tampa, Florida, 33612, United States
University of Southern California

Los Angeles, California, 90033, United States
University of Utah

Salt Lake City, Utah, 84132, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
University of Washington

Seattle, Washington, 98195, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University

Henrico, Virginia, 23233, United States
Wake Forest Health Science

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale University

New Haven, Connecticut, 06519, United States

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