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Spit test could spot ALS early

NCT ID NCT05928416

Ongoing Diagnosis Sponsor: ZIWIG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a simple saliva sample can help diagnose amyotrophic lateral sclerosis (ALS). Researchers will analyze RNA in the saliva of 653 people, including ALS patients and healthy volunteers. If the test works, it could offer a faster, less invasive way to diagnose ALS.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple, non-invasive saliva test to help diagnose ALS earlier.
What could go wrong
This is an observational study, not a treatment trial. The test may not be accurate enough to replace current diagnostic methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS AMYOTROPHIC LATERAL SCLEROSIS, SPORADIC

Contacts and locations

Locations

  • C.H.U. de Saint-Étienne

    Saint-Étienne-de-Montluc, Pays de la Loire Region, 42055, France

  • CHRU Lille

    Lille, 59037, France

  • CHU Angers

    Angers, 49933, France

  • CHU Bordeaux

    Bordeaux, 33000, France

  • CHU Bretonneau

    Tours, 37044, France

  • CHU Caen

    Caen, 14000, France

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003, France

  • CHU Dupuytren

    Limoges, 97042, France

  • CHU Montpellier

    Montpellier, 34295, France

  • CHU Nantes

    Saint-Herblain, Loire-Atlantique, 44162, France

  • CHU Nice

    Nice, 06100, France

  • CHU Rennes

    Rennes, 35000, France

  • CHU Strasbourg

    Strasbourg, Alsace, 67098, France

  • CHU Toulouse

    Toulouse, 31059, France

  • CHU de la Réunion

    Saint-Pierre, 97448, France

  • Hospices Civils de Lyon

    Bron, Rhône, 69677, France

  • Hôpital Cavale Blanche

    Brest, 29609, France

  • Hôpital de La Timone

    Marseille, 13005, France

  • Hôpital de la Pitié-Salpêtrière

    Paris, 75013, France

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