New ALS drug safety trial shows promise, but no cure yet

NCT ID NCT04632225

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 25 times

Summary

This study tested whether a drug called engensis is safe for people with amyotrophic lateral sclerosis (ALS), a disease that weakens muscles over time. Eighteen adults with limb-onset ALS received either engensis or a placebo injection. The main goal was to check for side effects, while also exploring if the drug might help muscle function or quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Austin Neuromuscular Center

    Austin, Texas, 78759, United States

  • Hanyang University Medical Center

    Seoul, 04763, South Korea

  • Johns Hopkins University Department of Neurology

    Baltimore, Maryland, 21205, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • St. Joseph's Hospital and Medical Center, Barrows Neurological Institute

    Phoenix, Arizona, 85013, United States

Conditions

Explore the condition pages connected to this study.