New breathing device could help ALS patients clear their lungs

NCT ID NCT05819931

Recruiting now Symptom relief Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests a mechanical in-exsufflator (MIE) device that helps ALS patients cough more effectively by pushing air in and then pulling it out. The goal is to see if daily use for four weeks can maintain or improve lung function. The study will enroll 36 adults with ALS who have a weak cough.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mechanical In-Exsufflator (MIE) device
What this could lead to: If it works, this device could help ALS patients clear their airways more easily, potentially slowing respiratory decline and improving quality of life.
What could go wrong: This is a small pilot study with only 36 participants, so results may not apply to all ALS patients. The device is meant to ease symptoms, not stop or reverse the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis Cough

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

Locations

SLA Center - Purpan University Hospital Toulouse, FRANCE
RECRUITING

Toulouse, Occitanie, 31000, France

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