Could this study unlock the secrets of ALS before symptoms start?

NCT ID NCT06581861

Recruiting now Knowledge-focused Sponsor: St. Joseph's Hospital and Medical Center, Phoenix Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study follows 600 adults who are genetically at risk for ALS due to family history. Over three years, researchers collect blood samples, speech recordings, and health data to track early signs of the disease. The goal is to build a rich database that scientists can use to better understand ALS and potentially find ways to prevent or delay it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help researchers understand early signs of ALS and develop ways to detect or delay the disease in at-risk individuals.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and results may take years to translate into clinical advances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States
CHALS-CCT, University of Puerto Rico, Medical Sciences Campus
RECRUITING

San Juan, Puerto Rico, 00935, Puerto Rico
Columbia University
RECRUITING

New York, New York, 10032, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Duke University
RECRUITING

Durham, North Carolina, 27705, United States

Contact Email: •••••@•••••
Georgetown University
RECRUITING

Washington D.C., District of Columbia, 200007, United States
Henry Ford Health
RECRUITING

Detroit, Michigan, 48202, United States
Hospital for Special Care
RECRUITING

New Britain, Connecticut, 06053, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
John Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
Massachusetts General Brigham
RECRUITING

Boston, Massachusetts, 02145, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Nih/Ninds
RECRUITING

Bethesda, Maryland, 20892, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States

Contact Email: •••••@•••••
Penn State Health
RECRUITING

Hershey, Pennsylvania, 17033, United States
Providence ALS Center
RECRUITING

Portland, Oregon, 97213, United States
Saint Alphonsus Regional Medical Center
RECRUITING

Boise, Idaho, 83704, United States
Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
Texas Neurology
RECRUITING

Dallas, Texas, 75206, United States
University of Alabama Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California Irvine
RECRUITING

Orange, California, 92868, United States
University of California San Diego
RECRUITING

La Jolla, California, 92037, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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