Can pridopidine slow ALS? major trial underway
NCT ID NCT07322003
First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This phase 3 trial is testing whether the drug pridopidine can slow the progression of amyotrophic lateral sclerosis (ALS) in 500 adults. Participants will take either pridopidine or a placebo daily for 48 weeks, followed by an open-label extension where everyone receives the drug. The study measures changes in physical function and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pridopidine
What this could lead to
If it works, this could point toward a treatment that slows the progression of ALS, helping people maintain function longer.
What could go wrong
This is a late-stage trial, but ALS is a tough disease and many promising drugs have failed before. The drug may not slow progression or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ALS Clinic Bonn University
RECRUITINGBonn, 53127, Germany
Contact Email: •••••@•••••
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Baylor College of Medicine; McNair Medical Campus
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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California Pacific Medical Center
RECRUITINGSan Francisco, California, 94109, United States
Contact Email: •••••@•••••
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Centro Clinico NEMO Fondazione Serena Onlus - ASST Niguarda Hospital
RECRUITINGMilan, 20126, Italy
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Centrum Medyczne Neuromed
RECRUITINGBydgoszcz, 85-163, Poland
Contact Phone: •••-•••-••••
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City Clinic Research Sp. z o.o.
RECRUITINGWarsaw, 02-473, Poland
Contact Email: •••••@•••••
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Clinical Hospital Santiago de Compostela
RECRUITINGSantiago de Compostela, 15706, Spain
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Eleanor and Lou Gehrig ALS Center at Columbia University
RECRUITINGNew York, New York, 10032, United States
Contact Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Genge Partners
RECRUITINGMontreal, Quebec, H4P 2N2, Canada
Contact Email: •••••@•••••
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Hadassah Medical Center
RECRUITINGJerusalem, IL 91120, Israel
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Hospital Universitari i Politècnic La Fe
RECRUITINGValencia, 46026, Spain
Contact Email: •••••@•••••
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Istituto Auxologico Italiano Ospedale San Luca
RECRUITINGMilan, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Linden sp. z o. o. sp. k.
RECRUITINGKrakow, 30-105, Poland
Contact Email: •••••@•••••
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Neuroscience Department at LKSM at Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact Email: •••••@•••••
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Royal Stoke University Hospital
RECRUITINGStoke-on-Trent, ST4 6QG, United Kingdom
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Sean M. Healey & AMG Center for ALS
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Somnos Clinical Research
RECRUITINGLincoln, Nebraska, 68506, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Studieenheten Akademiskt specialistcentrum
RECRUITINGStockholm, 113 61, Sweden
Contact Email: •••••@•••••
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Swedish Medical Center
RECRUITINGSeattle, Washington, 98122, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tel Aviv Sourasky Medical Center
RECRUITINGTel Aviv, 6423906, Israel
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Texas Neurology
RECRUITINGDallas, Texas, 75206, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UMC Utrecht
RECRUITINGUtrecht, Netherlands
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UZ Leuven
RECRUITINGLeuven, 3000, Belgium
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-••••
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Umeå University Hospital
RECRUITINGUmeå, 901 85, Sweden
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University of Kansas
RECRUITINGFairway, Kansas, 66205, United States
Contact Email: •••••@•••••
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University of South Florida
RECRUITINGTampa, Florida, 33612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
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Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••