Can pridopidine slow ALS? major trial underway

NCT ID NCT07322003

Recruiting now Disease control Sponsor: Prilenia Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 12, 2026 · Updated 16 times

Summary

This phase 3 trial is testing whether the drug pridopidine can slow the progression of amyotrophic lateral sclerosis (ALS) in 500 adults. Participants will take either pridopidine or a placebo daily for 48 weeks, followed by an open-label extension where everyone receives the drug. The study measures changes in physical function and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pridopidine
What this could lead to: If it works, this could point toward a treatment that slows the progression of ALS, helping people maintain function longer.
What could go wrong: This is a late-stage trial, but ALS is a tough disease and many promising drugs have failed before. The drug may not slow progression or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ALS Clinic Bonn University
RECRUITING

Bonn, 53127, Germany
ALS outpatient department at Charité - university medicine Berlin
RECRUITING

Berlin, 13353, Germany
ALS outpatient department at Charité - university medicine Berlin
RECRUITING

Berlin, Germany
Azienda Ospedaliero Universitaria Di Modena
RECRUITING

Modena, Italy
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States
Baylor College of Medicine; McNair Medical Campus
RECRUITING

Houston, Texas, 77030, United States
CHU Lille
RECRUITING

Lille, France
California Pacific Medical Center
RECRUITING

San Francisco, California, 94109, United States

Contact Email: •••••@•••••
Centre Hospitalier Universitaire de Nice
RECRUITING

Nice, France
Centre hospitalier régional universitaire de de Tours
RECRUITING

Tours, France
Centro Clinico NEMO Fondazione Serena Onlus - ASST Niguarda Hospital
RECRUITING

Milan, 20126, Italy
Centrum Medyczne Neuromed
RECRUITING

Bydgoszcz, 85-163, Poland
City Clinic Research Sp. z o.o.
RECRUITING

Warsaw, 02-473, Poland

Contact Email: •••••@•••••
Clinical Hospital Santiago de Compostela
RECRUITING

Santiago de Compostela, 15706, Spain
Eleanor and Lou Gehrig ALS Center at Columbia University
RECRUITING

New York, New York, 10032, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Genge Partners
RECRUITING

Montreal, Quebec, H4P 2N2, Canada
Hadassah Medical Center
RECRUITING

Jerusalem, IL 91120, Israel
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario La Paz - Carlos III
RECRUITING

Madrid, 28029, Spain
Hospital del Mar
RECRUITING

Barcelona, Spain
Hospitalier Pitié-Salpêtrière
RECRUITING

Paris, 75013, France
Hôpitaux Universitaires de Marseille Timone
NOT_YET_RECRUITING

Marseille, France
Istituto Auxologico Italiano Ospedale San Luca
RECRUITING

Milan, Italy
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
King's College Hospital
RECRUITING

London, United Kingdom
Linden sp. z o. o. sp. k.
RECRUITING

Krakow, 30-105, Poland
MDN Centre Queen Square Institute of Neurology
RECRUITING

London, United Kingdom
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
McMaster University Medical Centre
NOT_YET_RECRUITING

Hamilton, Canada
Neuroscience Department at LKSM at Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Royal Stoke University Hospital
RECRUITING

Stoke-on-Trent, ST4 6QG, United Kingdom
Sean M. Healey & AMG Center for ALS
RECRUITING

Boston, Massachusetts, 02114, United States
Somnos Clinical Research
RECRUITING

Lincoln, Nebraska, 68506, United States
Studieenheten Akademiskt specialistcentrum
RECRUITING

Stockholm, 113 61, Sweden
Swedish Medical Center
RECRUITING

Seattle, Washington, 98122, United States
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Texas Neurology
RECRUITING

Dallas, Texas, 75206, United States
Trinity College Dublin
RECRUITING

Dublin, Ireland
UMC Utrecht
RECRUITING

Utrecht, Netherlands
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Umeå University Hospital
RECRUITING

Umeå, 901 85, Sweden
University Hospital Jena
RECRUITING

Jena, Germany
University Hospital of Bellvitge
RECRUITING

Barcelona, Spain
University of Alberta
RECRUITING

Edmonton, Canada
University of Campania "Luigi Vanvitelli"
RECRUITING

Caserta, Italy
University of Colorado CU Anschutz Neurology
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••
University of Kansas
RECRUITING

Fairway, Kansas, 66205, United States
University of Padova
NOT_YET_RECRUITING

Padova, Italy
University of South Florida
RECRUITING

Tampa, Florida, 33612, United States
University of Torino
NOT_YET_RECRUITING

Torino, Italy
University of Ulm
RECRUITING

Ulm, 89081, Germany
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Universitätsklinikum Schleswig-Holstein
RECRUITING

München, Germany
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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