Could a fatty diet fight ALS?
NCT ID NCT06280079
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether an ultra-high-caloric diet made almost entirely of fat can help people with ALS live longer and slow the disease. Researchers will compare the diet to a low-fat placebo in 392 participants. The main goal is to see if the diet extends survival without the need for a breathing tube.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ultra-high-caloric fatty diet (100% fat, no protein or carbs)
- What this could lead to
- If it works, this could point toward a dietary approach to extend survival and slow decline in ALS.
- What could go wrong
- This is an early-stage trial without a standard phase, and the diet is extreme—it may be hard to tolerate or show no benefit over placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alfried Krupp Krankenhaus Essen
NOT_YET_RECRUITINGEssen, Germany
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Charité Universitätsmedizin Berlin
RECRUITINGBerlin, Germany
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DKD HELIOS Clinic Wiesbaden
RECRUITINGWiesbaden, Germany
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DRK Clinic Kassel
NOT_YET_RECRUITINGKassel, Germany
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Diakonissenkrankenhaus Mannheim
RECRUITINGMannheim, Germany
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Hannover Medical School
NOT_YET_RECRUITINGHanover, Germany
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Klinikum Kempten
NOT_YET_RECRUITINGKempten, Germany
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RWTH Aachen
NOT_YET_RECRUITINGAachen, Germany
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Technical University Dresden
NOT_YET_RECRUITINGDresden, Germany
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Technical University Munich
NOT_YET_RECRUITINGMunich, Germany
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University Clinic Bochum
NOT_YET_RECRUITINGBochum, Germany
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University Clinic Bonn
NOT_YET_RECRUITINGBonn, Germany
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University Clinic Erlangen
NOT_YET_RECRUITINGErlangen, Germany
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University Clinic Göttingen
NOT_YET_RECRUITINGGöttingen, Germany
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University Clinic Halle
NOT_YET_RECRUITINGHalle, Germany
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University Clinic Jena
NOT_YET_RECRUITINGJena, Germany
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University Clinic Leipzig
NOT_YET_RECRUITINGLeipzig, Germany
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University Clinic Lübeck
RECRUITINGLübeck, Germany
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University Clinic Münster
NOT_YET_RECRUITINGMünster, Germany
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University Clinic Regensburg
NOT_YET_RECRUITINGRegensburg, Germany
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University Clinic Rostock
NOT_YET_RECRUITINGRostock, Germany
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University Clinic Würzburg
NOT_YET_RECRUITINGWürzburg, Germany
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University of Ulm
RECRUITINGUlm, Germany
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