Heart drug could cramp ALS pain: new trial launches

NCT ID NCT06527222

Recruiting now Symptom relief Sponsor: Swathy Chandrashekhar, MBBS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if ranolazine, a heart medication, can safely reduce muscle cramps and improve quality of life in people with ALS. About 72 adults with ALS who have frequent cramps will receive either the drug or a placebo for 28 weeks. The main goals are to check safety and see if cramps become less frequent or severe.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis motor neuron disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

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Locations

Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Kansas Medical Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Medical Center: Wichita
RECRUITING

Wichita, Kansas, 67214, United States

Contact Email: •••••@•••••
University of Missouri Health Care
RECRUITING

Columbia, Missouri, 65212, United States

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