Sound waves against ALS: can opening the Brain's barrier slow the disease?

NCT ID NCT07571486

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This early study tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and might slow ALS. Twenty-three adults with ALS will receive 9 ultrasound sessions over 24 weeks. The first part checks safety; the second looks for signs of slowing the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SonoCloud-4 ultrasound device
What this could lead to: If successful, this could point toward a new way to treat ALS by temporarily opening the blood-brain barrier, potentially slowing disease progression.
What could go wrong: This is a very early, small study (23 people) testing safety first. It may not show any benefit, and the procedure carries risks like brain swelling or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis Neuroinflammatory Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS CHARCOT DISEASE

Contacts and locations

Locations

Hôpital Pitié-Salpêtrière
RECRUITING

Paris, 75013, France

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