New hope for rare brain disease: phase 3 trial of NIO752 underway

NCT ID NCT07498426

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tests an experimental drug called NIO752 in 300 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. Participants are randomly assigned to receive either the drug or a placebo. After the main study, everyone can receive the drug in an open-label extension. The goal is to see if NIO752 can slow the disease and improve daily function.

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Conditions

The condition(s) this trial relates to.

Pick disease progressive supranuclear palsy supranuclear palsy, progressive, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROGRESSIVE SUPRANUCLEAR PALSY RICHARDSON SYNDROME (PSP-RS)

Contacts and locations

Locations

CenExcel Rocky Mtn Clin Research
RECRUITING

Englewood, Colorado, 80113, United States
Klinik für Neurologie (Schwerpunkt Neurodegeneration)
RECRUITING

Ulm, 89081, Germany
Mayo Clinic
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Rochester, Minnesota, 55905, United States
Mayo Clinic Arizona
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Scottsdale, Arizona, 85259, United States
Mayo Jacksonville
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Jacksonville, Florida, 32224, United States
Novartis Investigative Site
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Westmead, New South Wales, 2145, Australia
Novartis Investigative Site
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Melbourne, Victoria, 3004, Australia
Novartis Investigative Site
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Shanghai, 200040, China
Novartis Investigative Site
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Suzhou, 215000, China
Novartis Investigative Site
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Caen, 14033, France
Novartis Investigative Site
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Créteil, 94010, France
Novartis Investigative Site
RECRUITING

Lille, 59037, France
Novartis Investigative Site
RECRUITING

Marseille, 13885, France
Novartis Investigative Site
RECRUITING

Nantes, 44093, France
Novartis Investigative Site
RECRUITING

Paris, 75013, France
Novartis Investigative Site
RECRUITING

Rennes, 35033, France
Novartis Investigative Site
RECRUITING

Toulouse, 31059, France
Novartis Investigative Site
RECRUITING

Munich, Bavaria, 81377, Germany
Novartis Investigative Site
RECRUITING

Würzburg, Bavaria, 97080, Germany
Novartis Investigative Site
RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
Novartis Investigative Site
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Novartis Investigative Site
RECRUITING

Dresden, Saxony, 01307, Germany
Novartis Investigative Site
RECRUITING

Leipzig, Saxony, 04103, Germany
Novartis Investigative Site
RECRUITING

Beelitz, 14547, Germany
Novartis Investigative Site
RECRUITING

Berlin, 13353, Germany
Novartis Investigative Site
RECRUITING

Stadtroda, 07646, Germany
Novartis Investigative Site
RECRUITING

Tübingen, 72076, Germany
Novartis Investigative Site
RECRUITING

Milan, MI, 20133, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00168, Italy
Novartis Investigative Site
RECRUITING

Kodaira, Tokyo, 187-8551, Japan
Novartis Investigative Site
RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Novartis Investigative Site
RECRUITING

Nijmegen, 6525 GA, Netherlands
Novartis Investigative Site
RECRUITING

Seoul, 03722, South Korea
Novartis Investigative Site
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08036, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08041, Spain
Novartis Investigative Site
RECRUITING

Las Palmas GC, 35010, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28009, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28034, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28041, Spain
Novartis Investigative Site
RECRUITING

Seville, 41013, Spain
Univ of California San Francisco
RECRUITING

San Francisco, California, 94158, United States