New hope for rare brain disease: phase 3 trial of NIO752 underway
NCT ID NCT07498426
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called NIO752 in 300 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. Participants are randomly assigned to receive either the drug or a placebo. After the main study, everyone can receive the drug in an open-label extension. The goal is to see if NIO752 can slow the disease and improve daily function.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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CenExcel Rocky Mtn Clin Research
RECRUITINGEnglewood, Colorado, 80113, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Klinik für Neurologie (Schwerpunkt Neurodegeneration)
RECRUITINGUlm, 89081, Germany
Contact Email: •••••@•••••
Contact
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Email: •••••@•••••
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Mayo Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Novartis Investigative Site
RECRUITINGMelbourne, Victoria, 3004, Australia
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Novartis Investigative Site
RECRUITINGCaen, 14033, France
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Novartis Investigative Site
RECRUITINGCréteil, 94010, France
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Novartis Investigative Site
RECRUITINGParis, 75013, France
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Novartis Investigative Site
RECRUITINGToulouse, 31059, France
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Novartis Investigative Site
RECRUITINGBonn, North Rhine-Westphalia, 53127, Germany
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Novartis Investigative Site
RECRUITINGDüsseldorf, North Rhine-Westphalia, 40225, Germany
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Novartis Investigative Site
RECRUITINGLeipzig, Saxony, 04103, Germany
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Novartis Investigative Site
RECRUITINGBerlin, 13353, Germany
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Novartis Investigative Site
RECRUITINGStadtroda, 07646, Germany
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Novartis Investigative Site
RECRUITINGMilan, MI, 20133, Italy
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Novartis Investigative Site
RECRUITINGRoma, RM, 00168, Italy
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Novartis Investigative Site
RECRUITINGKodaira, Tokyo, 187-8551, Japan
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Novartis Investigative Site
RECRUITINGRotterdam, South Holland, 3015 GD, Netherlands
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Novartis Investigative Site
RECRUITINGBarcelona, 08036, Spain
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Novartis Investigative Site
RECRUITINGLas Palmas GC, 35010, Spain
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Novartis Investigative Site
RECRUITINGMadrid, 28009, Spain
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Novartis Investigative Site
RECRUITINGMadrid, 28034, Spain
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Novartis Investigative Site
RECRUITINGSeville, 41013, Spain
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Univ of California San Francisco
RECRUITINGSan Francisco, California, 94158, United States
Contact Email: •••••@•••••
Contact