Dementia

This Phase 2 study tested ABvac40, a vaccine designed to help the immune system target and clear a protein called amyloid-beta 40, which builds up in the brains of people with Alzheimer's. The trial included 134 adults aged 55-80 with mild cognitive impairment or very mild Alzhei…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This large Phase 3 trial tested whether the diabetes drug semaglutide, taken as a daily pill, can slow cognitive decline in people with early Alzheimer's disease. About 1,840 participants received either semaglutide or a placebo for up to 3 years and 4 months. The study measured …

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants…

This study tested the safety and effects of nilotinib, a cancer drug, in 43 people with Dementia with Lewy Bodies (DLB). DLB is a common type of dementia that shares features with Parkinson's and Alzheimer's. The goal was to see if nilotinib is safe and changes brain biomarkers, …

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether adding slow, paced breathing exercises to computer-based brain training could improve thinking skills and slow dementia in older adults with mild cognitive impairment. Over 8 weeks, 113 participants either did both breathing and brain training, brain tra…

This early-stage study tested whether multiple infusions of donor stem cells are safe for people with mild to moderate Alzheimer's disease. Six participants received the treatment and were monitored for serious side effects and changes in thinking skills. The goal was to check sa…

This large Phase 3 study tested an experimental drug called remternetug in over 1,600 people with early symptoms of Alzheimer's disease. The main goal was to see if the drug could safely clear amyloid plaques from the brain, a hallmark of Alzheimer's. Participants received either…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This study tested whether restoring proper chewing function through dental implants or braces could improve cognitive health in adults. Researchers enrolled 150 people with missing teeth or misaligned bites. They measured changes in brain activity, thinking skills, and mood. The …

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This early-stage trial tested an experimental drug called SHR-1707 in 33 people with mild memory problems or mild Alzheimer's disease. The drug is an antibody given through a vein, designed to target and clear amyloid plaques in the brain. The main goal was to check safety and si…

This study tested a special tablet exercise program called KOKU-LITE, designed for people with dementia to help prevent falls and improve well-being. Sixty people with dementia and their carers took part to see if the program was easy to use and helpful. The goal was to see if th…

This pilot study tested whether a short course of low-dose radiation to the brain could reduce amyloid plaques, a hallmark of Alzheimer's disease. Twenty people with early Alzheimer's and positive amyloid scans were enrolled. Half received radiation over 5 days, while the other h…

This completed phase 1 study tested whether taking choline, a dietary supplement, for 6 months could improve fat metabolism in the brain of people with the APOE4 gene, which raises Alzheimer's risk. Fifteen participants aged 55-80 took choline capsules twice daily. The main goal …

This study followed 24 people with metachromatic leukodystrophy (MLD), a rare and serious brain disease, who were already receiving an experimental drug called HGT-1110. The main goal was to check for side effects and immune reactions over a long period. Researchers wanted to see…

This study adapted a proven mouth care program for nursing homes to work in assisted living facilities for people with dementia. Nursing assistants were trained to provide daily mouth care and given supplies. The goal was to reduce harmful mouth bacteria that can lead to pneumoni…

This completed Phase 2a study tested an oral drug called neflamapimod in 26 people with dementia with Lewy bodies. The main goal was to check safety and how the drug moves through the body over 24 weeks. Researchers also looked at changes in thinking and memory as a secondary mea…

This completed Phase 3 trial tested whether oral semaglutide (a drug used for diabetes and weight loss) can slow cognitive decline in 1840 people with early Alzheimer's disease. Participants received either semaglutide or a placebo daily for up to 3 years and 4 months. The study …

This trial tested a custom-made drug called nL-TARD-001 in one person with ALS caused by a specific genetic mutation in TARDBP. The drug is an antisense oligonucleotide designed to target the faulty gene. The study measured changes in muscle function, breathing, and thinking over…

This Phase 2 study tested a once-daily combination pill (polypill) in 121 adults aged 50–85 with very mild to severe Alzheimer's disease. Over 180 days, researchers measured changes in thinking, memory, and daily function using standard dementia scales. The goal was to estimate w…

This study tested a drug called TPN-101 in 42 people with ALS or frontotemporal dementia caused by a specific gene change (C9orf72). The main goal was to check if the drug is safe and tolerable over 48 weeks. Researchers also looked at how the drug moves in the body and whether i…

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study looked at whether a plant-based ketogenic diet combined with intermittent fasting (called Ketoflex 12/3) could slow the progression of early-to-mid stage Alzheimer's disease. Sixty participants followed the diet, and researchers measured changes in memory and thinking …

This completed trial tested a ketogenic diet (high-fat, low-carb) in 32 people with mild to moderate Alzheimer's disease. Participants followed the diet or a placebo for 26 weeks. Researchers measured changes in cognitive function using a standard test. The goal was to see if the…

This study tested whether a year of twice-weekly resistance training could protect brain health and thinking skills in 91 older adults with vascular cognitive impairment, a condition linked to small strokes. Participants were randomly assigned to either resistance training or a s…

This study tested a drug called donanemab (LY3002813) in 272 people with early symptoms of Alzheimer's disease. The goal was to see if the drug is safe and can slow down memory loss and daily functioning problems. Participants received either the drug or a placebo, and researcher…

This study tested a gene therapy called OTL-200 in 10 children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. The treatment uses the child's own blood stem cells, modified to produce a missing enzyme, and aims to slow or stop disease progres…

This study tested whether a non-invasive brain stimulation method called tACS could reduce amyloid and tau proteins in people with mild to moderate Alzheimer's. Seventeen participants received daily sessions of tACS or a sham treatment for 2-4 weeks. The goal was to see if the st…

This study tested whether narrow dental implants work as well as standard-sized implants placed with bone regeneration in people with narrow jawbone in the back of the mouth. Thirty adults with a ridge width between 5 and 6.5 mm received either a 3.0 mm narrow implant or a 4.0 mm…

This study tested an experimental drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The go…

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received injections of a harmless virus carrying a working copy of the ARSA gene directly into their brains. …

This study looked at whether semaglutide, a medicine used for diabetes and weight loss, can reduce inflammation in the brain and body of people with early Alzheimer's disease. Twenty-three participants with mild memory problems or mild dementia received either semaglutide or a pl…

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This study tested a 12-week intensive exercise program (aerobic and resistance training) in 58 adults aged 40-85 with type 2 diabetes and mild cognitive issues. The goal was to see if exercise could improve thinking, blood sugar, inflammation, and physical function. Results may h…

This study tested whether a personalized treatment plan—based on each person's test results—works better than standard care for people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part, receiving either the tailored plan or usual care for 9 mo…

This study tested a low dose of nilotinib, a drug used for leukemia, in 37 people with mild to moderate Alzheimer's disease. The goal was to see if the drug is safe and can reach the brain to affect proteins linked to Alzheimer's, like tau and amyloid. Participants took the drug …

This study tested a supplement called HOV-12020 (made from palm tocotrienols) in 50 adults aged 45-75 with CADASIL, a rare genetic disease that damages small blood vessels in the brain, leading to strokes and memory loss. The goal was to see if the supplement could reduce worseni…

This completed study tested whether two diabetes medications, sitagliptin and dapagliflozin, are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 participants took either a drug or a placebo daily for a short time. The goal w…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study tested a device that uses focused ultrasound to temporarily open the blood-brain barrier in 35 people with Alzheimer's disease. The goal was to see if this procedure is safe and could help treatments reach the brain more effectively. Participants were between 50 and 85…

This early-stage trial tested a drug called NIO752 in 59 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. The drug was given as a spinal injection to see if it is safe and how the body processes it. The main goal was to ch…

This first-in-human study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The drug is an antibody that targets PD-L1, a protein involved in immune regulation. The main goal was to check safety and how the drug moves through the body, not yet to pro…

This study tested whether early cognitive training and rehabilitation can improve long-term thinking skills in older adults (65+) who experienced delirium during a hospital stay. 283 participants were randomly assigned to receive either the cognitive training program or usual car…

This study tested an oral drug called ALZ-801 in 84 people with early Alzheimer's who carry the APOE4 gene variant, which increases risk. Researchers measured changes in blood and brain scan markers of Alzheimer's over 65 weeks to see if the drug slows disease progression. The go…

This study tested an experimental drug called ABBV-916 in people with early Alzheimer's disease. Participants received either the drug or a placebo intravenously every 4 weeks for 6 months, with an optional 2-year extension where everyone gets the drug. The goal was to check safe…

This study tested a gene therapy for children with metachromatic leukodystrophy (MLD), a rare, inherited brain disease that causes severe disability and early death. The treatment uses the child's own blood stem cells, which are modified in a lab to carry a working copy of the mi…

This study tested a drug called AL001 in 33 people who carry a gene mutation that causes frontotemporal dementia, a brain disease that affects personality and language. The goal was to see if the drug is safe and how it affects certain proteins in the body. The trial was open-lab…

This study tested different doses of nicotinamide riboside (a form of vitamin B3) in 80 people with early Alzheimer's disease. The goal was to find the dose that best boosts brain energy levels and changes brain metabolism with the fewest side effects. Participants took placebo o…

This completed Phase 2 trial tested a drug called DAAOI-P in 61 people with Parkinson's disease who also have dementia. The goal was to see if the drug could improve walking, reduce falls, and ease neuropsychiatric symptoms. Participants received either DAAOI-P or a placebo pill …

This small pilot study tested daratumumab, a cancer drug, in 16 people with mild to moderate Alzheimer's. The goal was to see if it could improve thinking and memory. Participants received daratumumab injections under the skin. The study was open-label, meaning everyone knew they…

This study tested an experimental drug called ALZ-801 in 325 people with early Alzheimer's disease who carry two copies of the APOE4 gene, a strong risk factor. Participants received either the drug or a placebo for a year. Researchers measured changes in memory, thinking, and da…

This early-stage study tested the safety of a new drug called BMS-984923 in 51 healthy older adults and people with Alzheimer's disease. Participants received either the drug or a placebo to check for side effects and how the body processes the medication. The goal was to see if …

This study looked at how people with PKAN, a rare genetic brain disorder, respond to a special vitamin metabolite. Researchers wanted to see if it is safe and if it changes any signs of the disease. 77 people aged 3 months to 89 years took part.

This study tested an experimental drug called AL002 in 356 people with early Alzheimer's disease. The goal was to see if it could slow down memory and thinking problems compared to a placebo. Participants received either the drug or a dummy injection, and their symptoms were trac…

This study tested whether a nasal insulin spray and a diabetes pill called empagliflozin, alone or together, could improve memory and brain function in 47 adults aged 55-85 with mild cognitive impairment or early Alzheimer's disease. The goal was to see if these treatments are sa…

This study tested a tablet-based platform called Tenèpsia® for remote cognitive assessments in 250 healthy adults and people with cognitive impairment. The goal was to collect normal test scores and validate the digital tool for diagnosing neurocognitive disorders. If proven reli…

This study looked at whether a special brain scan called 18F-FDG PET can help doctors tell the difference between cognitive problems caused by psychiatric conditions versus neurodegenerative diseases like Alzheimer's. Researchers studied 20 adults with cognitive impairment who ha…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing simple self-figure drawings. Over 3,400 older adults drew themselves on paper, and the AI learned to spot patterns linked to cognitive decline. …

This study tested a new digital tool that uses artificial intelligence to analyze a person's speech during three one-minute verbal fluency tests. The goal was to see if it could accurately detect mild cognitive impairment (MCI) or early dementia. The study involved 221 adults age…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study tested whether an automated speech analysis tool called AcceXible can help detect mild cognitive impairment or dementia early. Researchers analyzed speech patterns from 273 adults aged 55 and older, including healthy individuals and those with memory concerns. The goal…

This completed study looked at whether combining an online memory test with a blood test can help find Alzheimer's disease early in people 65 and older. Over 1,400 volunteers took part. The goal is to make early detection easier and faster, so treatment can start sooner.

This study tested a low-cost method to find undiagnosed dementia in primary care. Researchers used electronic health records to identify patients at risk. Over 1,200 adults without a prior dementia diagnosis took part. The goal was to see if this approach could increase new demen…

This study tested whether a computer program called SCALE PET helps doctors more accurately spot signs of Alzheimer's disease in brain scans. Researchers looked at 190 past scans from people with Alzheimer's or mild memory problems. Four doctors read the scans twice—once with the…

This study looked at whether measuring a protein called amyloid beta 1-40 in spinal fluid can help doctors diagnose Alzheimer's disease more accurately. Researchers collected spinal fluid from 204 people with memory problems. They want to see if adding this new measurement to exi…

This study tested a smartphone app that analyzes voice recordings to see if it can accurately diagnose mild cognitive impairment (MCI) and Alzheimer's disease. Researchers compared the app's diagnosis to a doctor's diagnosis in 150 adults aged 50 and older. The goal was to see if…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, compared to the current standard of testing spinal fluid. Researchers measured specific proteins in the blood of 342 adults visiting memory clinics. The goal was to see if these blood markers c…

This study tested a new blood test that uses a microfluidic chip to detect Alzheimer's disease. Researchers collected blood and urine samples from 150 people, including those with Alzheimer's, other brain diseases, and healthy volunteers. The goal was to see if the test could acc…

This study is working on a blood test to help diagnose Alzheimer's disease. Researchers are measuring two specific markers in the blood of 200 people—some with Alzheimer's and some healthy—to see if these markers can reliably tell the difference. The goal is to create a simple, n…

This study looked at whether a finger prick blood sample can accurately measure a key Alzheimer's biomarker (pTau-217) compared to a standard blood draw. 49 adults already in another Alzheimer's study provided both types of samples. The goal was to see if the finger prick method …

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether a health belief model-based education program could improve knowledge about dementia and increase motivation to adopt healthy behaviors in adults aged 60 and older. 66 participants without dementia took part. The program aimed to help seniors understand …

This study tested whether a structured lifestyle program—including diet, exercise, and cognitive training—can help prevent cognitive decline in older adults at risk for dementia. Over 1,000 participants aged 60-77 from 12 Latin American countries took part. The goal was to see if…

This study looked at whether 6 months of moderate aerobic exercise could improve memory and brain health in older adults (ages 60-80) who are inactive but cognitively healthy. Some participants carried a gene (APOE-ε4) that raises Alzheimer's risk. They were randomly assigned to …

This study tested whether an 8-week course led by a robot (Kebbi) could help prevent cognitive decline in 80 community-dwelling adults aged 65+ with mild cognitive impairment. The experimental group interacted with the robot in small groups, playing board games and learning, whil…

This early-stage trial tests a vaccine called AV-1959R, designed to prevent Alzheimer's disease by targeting a protein linked to the condition. Sixteen healthy adults aged 40-60 will receive three shots of the vaccine or a placebo over 14 weeks. Researchers will monitor for side …

This study tested a 4-week sleep health program in 30 adults aged 45-64 to see if it could improve sleep and potentially delay Alzheimer's disease. Participants learned strategies to enhance their sleep health. The study measured how acceptable and effective the program was, usin…

This study tested a 12-week "Active Brain Construction Program" for adults aged 55 and older living in the community. The program used coaching to help participants adopt healthy habits linked to dementia prevention. Researchers compared coached, non-coached, and control groups t…

This study looked at how common mild cognitive impairment is among adults aged 50-65 in Kerala, India, and tested a one-month program combining nutrition advice, exercise, brain games, social support, and heart health management. The goal was to see if this approach is practical …

This study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 adults aged 65-80 living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the prog…

This study tested whether lifestyle changes—like a healthy diet, physical and mental exercise, and managing health risks—can protect memory and thinking in older adults at risk for Alzheimer's disease. Researchers enrolled 2,000 Americans who were sedentary and had a low-quality …

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while researche…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild memory or thinking problems more than exercise alone. Thirty-four participants will be followed for six months to measure changes in activity level, thinking skills…

This study tested whether older adults with mild cognitive impairment or early Alzheimer's can use a tablet-based brain-training app at home. 52 participants played 12 different games for 8 minutes each, daily for two weeks. The goal was to see if the app was easy to use and acce…

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This study tests whether the drug mevidalen can safely improve thinking, memory, and daily function in people with mild-to-moderate Alzheimer's disease. About 300 participants will receive either mevidalen or a placebo for 26 weeks. The main goal is to see if the drug eases sympt…

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study tests whether Snoezelen multisensory therapy — a calming, personalized experience using lights, sounds, textures, and scents — can reduce agitation, depression, and anxiety in older adults with dementia. Sixty participants with mild to moderate dementia will receive ei…

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This study tests whether an 8-week choral singing program can improve the well-being of nursing home residents with dementia. Participants attend one 75-minute group singing session each week, plus a dress rehearsal and final concert. Researchers measure changes in stress hormone…

This study tested whether combining a gentle brain stimulation technique called tDCS with memory and thinking exercises could help people with early Alzheimer's. Twenty-two participants received either real or fake stimulation during 10 sessions of cognitive training. Researchers…

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study tested a 12-week music therapy program for 76 care home residents with dementia or cognitive impairment. Residents received individual music therapy sessions, and staff were trained to use music techniques. The goal was to see if music therapy could reduce unmet care n…

This study tests whether adding a caregiver training program to a visual mapping assistive technology (MapHabit) improves daily life for people with Alzheimer's or dementia and reduces stress for their caregivers. Fifty patient-caregiver pairs will use either the technology alone…

This study tested if immersive virtual reality (VR) can improve memory and thinking in people with Alzheimer's disease. 33 participants wore VR headsets to explore scenes from 1960s Burgos, Spain, designed to trigger personal memories. Researchers measured changes in cognitive te…

This study tested a non-invasive brain stimulation technique called rTMS, guided by each person's unique brain activity map, to see if it could improve thinking and memory in 46 people with mild Alzheimer's disease. Participants received either real or fake (placebo) stimulation …

This study tested a gentle brain stimulation technique (HD-tDCS) combined with computer-based memory exercises in 60 people with early Alzheimer's. The goal was to see if this combination could improve thinking and memory more than either treatment alone. Researchers also used br…

This study tested whether personalized magnetic brain stimulation (TMS) is safe and helpful for people with early Alzheimer's disease. Forty participants received either real or fake TMS to see if it could improve memory and thinking. The goal was to find a non-drug way to ease s…

This study tested a prescription smartphone app called RiSolve for women with overactive bladder (OAB). The app provides an 8-week program of bladder training, pelvic floor exercises, and digital cognitive behavioral therapy. Researchers enrolled 46 women in Ireland to see if the…

This study tested a safe, non-invasive brain stimulation technique called tACS in 26 people with mild cognitive impairment due to Alzheimer's. The goal was to see if a 40 Hz electrical current applied to the brain could improve memory. Participants completed memory tests before, …

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This study tested a sublingual film containing dexmedetomidine (BXCL501) to quickly calm agitation in 100 older adults with dementia. Participants received either the drug or a placebo, and researchers measured changes in agitation scores and side effects. The goal was to find a …

This study tested an online education program called 'Caregiving While Black' to help Black American caregivers feel more confident and less stressed while caring for a family member or friend with dementia. About 140 caregivers took part. The program focused on building skills a…

This study tested an online training program called CHATO for nursing home staff who care for people with Alzheimer's or other dementias. The training aimed to improve how staff communicate, which may reduce behavioral symptoms like agitation or rejection of care. Over 5,000 staf…

This pilot study tested a website tool called WeCareToFeedDysphagia designed to reduce feelings of burden in caregivers of people with Alzheimer's or related dementias who also have trouble swallowing. Eighty caregivers were split into two groups: one got access to the tool plus …

This completed trial tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease build a habit of walking at least 250 steps each hour. The 12-week program used goal setting, action planning, self-monitoring, and prompts to encourage reg…

This study tested whether partnered rhythmic dance is safe and helpful for people with early Alzheimer's disease. 76 participants were randomly assigned to either dance classes or a walking program for 12 months. The goal was to see if dance improves the ability to think and move…

This small study tested whether using a rocking chair for an hour each day could help reduce agitation in elderly people with dementia. Twelve nursing home residents took part in daily rocking sessions for six weeks. Researchers measured changes in agitation, use of calming medic…

This early-stage study tested an experimental drug, NMRA-323511, in healthy older adults and people with Alzheimer's disease who experience agitation. The goal was to see if the drug is safe and can reduce agitated behaviors like pacing or yelling. The study involved 87 participa…

This study tested whether adding acupuncture to standard care can slow down memory and thinking problems in people with mild Alzheimer's disease. Researchers compared real acupuncture to a fake (sham) procedure in 160 participants to see if the effects were real or just a placebo…

This study tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease develop a regular walking habit. Over 12 weeks, participants received texts with goal-setting, action plans, and reminders to walk at least 1,000 steps in a set hour …

This study tested a program called EnACT for family caregivers of people with dementia. The program uses group sessions where caregivers watch scenarios, practice responses, and reflect on their choices. The goal is to help caregivers feel more prepared and less stressed when dea…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether 20 hours of computer-based executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. About 119 participants were split into a training group and a no-contact control g…

This study looked at whether visits from therapy animals can improve mood, behavior, and quality of life for people with moderate to severe dementia living in nursing homes. Researchers observed 20 participants and compared animal visits to other activities. The goal was to see i…

This study tested whether adding Turkish music to a functional exercise program helps older adults with mild dementia more than exercise alone. Forty participants from a nursing home did exercises twice a week for 8 weeks, with half listening to music during the sessions. Researc…

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested a Dialectical Behavior Therapy skills training program for older adults (age 50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers participated, and the program foc…

This study tested whether virtual music therapy can lower stress as well as live music therapy in older adults with memory problems. Thirty-two participants from assisted living facilities took part. Researchers measured stress through surveys, heart rate, and blood pressure befo…

This study tested a set of tablet games called VibrantMinds, designed to be easy and fun for older adults, including those with dementia. 26 participants aged 65+ with mild cognitive impairment played games like Whack-A-Mole and Word Search. Researchers measured changes in thinki…

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study tested whether a socially assistive robot could reduce apathy in older adults with mild cognitive impairment or Alzheimer's disease living in long-term care. 142 participants were randomly assigned to either usual activities or usual activities plus robot-led sessions.…

This study tested a personalized approach to manage agitation in people with Alzheimer's disease living at home. A nurse worked with doctors and caregivers to create a custom care plan, using video calls and training. The goal was to reduce hospitalizations and ease caregiver str…

This study tested whether tongue-strengthening exercises using a special device could improve swallowing in people with Alzheimer's disease and related dementias. 76 participants with mild to moderate dementia did exercises over 8 weeks. The goal was to reduce food or liquid goin…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested a software system that uses a humanoid robot to give cognitive and motor tests to people with early Alzheimer's or other mild to moderate dementia. The goal was to see if the robot could effectively administer tests like the Mini Mental State Exam (MMSE) and hel…

This study tested an experimental drug called neflamapimod in 159 people with dementia with Lewy bodies (DLB). The goal was to see if it could improve memory, problem-solving, and attention compared to a placebo. Participants took the drug or a dummy pill for a set period, and re…

This study tested a new drug called phenserine in 16 people with early or mild Alzheimer's disease. The goal was to see how it affects brain cell health and inflammation compared to the standard drug donepezil. Participants took the drug for 8 weeks and had regular checkups. The …

This study tested a new behavioral program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and reminders. The goal was to help them stay independent in daily life. 68 older adults took part, and rese…

This early-stage study tested the safety of a new drug called MK-8189 (elpipodect) in 29 people with Alzheimer's disease who also had symptoms like agitation, aggression, or psychosis. The main goal was to see if the drug was safe and tolerable. Researchers monitored side effects…

This study tested a program called Cuidando Juntos, designed to support Latino caregivers of people with dementia. The program includes eight modules on stress management, self-care, and handling difficult behaviors. Researchers wanted to see if the program was well received and …

This study tested whether a social robot named Kebbi could improve thinking, heart rate patterns, and emotional well-being in 136 older adults with mild dementia living in long-term care. Participants in the robot group spent 30 minutes with Kebbi three times a week for 12 weeks,…

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This study tested whether playing interactive digital games in a group could improve mood, behavior, and thinking in 24 older adults with early to moderate dementia. Participants played games like Mahjong on a touch-sensitive table twice a week for 20 weeks. Researchers measured …

This study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…

This completed study tested a structured music improvisation program for older adults with mild to moderate dementia and their caregivers. Seven participants took part in three-hour sessions led by professional musicians. The goal was to see if this non-drug approach could improv…

This study tested whether a virtual reality program featuring nostalgic scenes from Taiwanese culture could improve mood, life satisfaction, and thinking skills in older adults with mild cognitive impairment or mild dementia. Sixty-four participants aged 65 and older were randoml…

This study tested a web platform designed for people with mild cognitive impairment or mild to moderate dementia and their primary caregivers. The platform offers social networks, activities, and games to improve quality of life and help them stay in the community longer. Researc…

This study tested whether simple brain function measures can predict which Alzheimer's patients will respond to the drug memantine. 53 participants with mild-to-moderate Alzheimer's took memantine or placebo, then all received memantine for 24 weeks. The goal was to see if early …

This study tested a smartphone app designed to help unpaid caregivers of people with dementia reduce their stress and burden. 150 caregivers used the app for 8 weeks, and researchers measured changes in stress, anxiety, and depression. The app provides practical strategies based …

This study tested whether a painless, non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's disease. Researchers used MRI…

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested a web-based program called RELOAD-C designed to reduce loneliness in people caring for a family member or friend with Alzheimer's disease. The program uses short videos and online group discussions based on Meaning-Centered Psychotherapy to help caregivers find …

This study tested if a gentle, non-invasive brain stimulation device used at home can help improve memory and thinking in people with mild to moderate Alzheimer's disease. One hundred older adults used the device for 30 minutes a day, five times a week, for six months. The goal w…

This study tested a new way to follow up with gynecologic cancer survivors. Instead of seeing a doctor every time, patients saw a nurse at every other visit and used a smartphone app to help manage their health. The goal was to see if this approach improved self-management skills…

This study tested whether adding a virtual reality experience to an online education program could help reduce stress and anxiety in people caring for a loved one with mild-to-moderate Alzheimer's disease. About 127 unpaid caregivers took part, with some receiving only the educat…

This study tested an online platform called the Living Memory Home for Dementia Care Pairs (LMH-4-DCP). It helps people with dementia and their family caregivers share and record meaningful memories together. The goal was to see if using the platform could reduce feelings of grie…

This study tested whether repeated sessions of transcranial magnetic stimulation (TMS) could improve language in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Ten participants received both real and sham (fake) TMS ove…

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see …

This study tested a gentle bathing technique based on Basale Stimulation for people with moderate to severe dementia. The approach uses soft mittens, warm water, and careful movements to reduce distress and increase engagement during showers. Fifty participants were videotaped du…

This study tested whether a six-week sleep therapy program (CBT-I) could improve thinking and memory in older adults aged 60-85 with insomnia. Two hundred participants were randomly assigned to either CBT-I or a sleep education program. A small group also had brain scans to see i…

This study tested a sleep improvement program designed for both people with Alzheimer's disease and the family members who care for them. The program was tailored to address sleep problems in both the patient and caregiver at the same time. The goal was to see if this approach co…

This completed study tested whether wearing a special graphene cap that emits far-infrared heat could improve thinking and mood in older adults with mild cognitive decline or Alzheimer's. 126 participants were split into groups based on their cognitive level and received either t…

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinkin…

This study tested whether a virtual group therapy program called Cognitive Stimulation Therapy (V-CST) could help slow cognitive decline in people with mild to moderate dementia. 133 participants were randomly assigned to either receive a referral for V-CST or continue with stand…

This study tested a video-based program called Tele-STELLA for family members caring for someone with moderate to late-stage Alzheimer's or related dementia. The program connects caregivers with a guide to find ways to manage upsetting behaviors. The goal was to see if it could r…

This study tested a virtual program called MASC (Mindful and Self-Compassionate Care) for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and behavioral management skills through six group sessions and home practice. T…

This small pilot study tested whether adding a horse to memory workshops could improve thinking, mood, and quality of life for people with mild to moderate dementia. Thirty-six older adults were split into three groups: traditional memory workshops, equine-assisted memory worksho…

This study gave robotic pets (like the Joy for All™ cat or dog) to 106 older adults with mild-to-moderate dementia during their hospital stay. The goal was to see if the pets could lower delirium risk, reduce falls, and cut down on strong medications. Researchers compared these p…

This study tested a drug called CT1812 in 130 people with mild to moderate Dementia with Lewy Bodies. Over 6 months, researchers checked if the drug was safe and if it helped with thinking, sleep, or other symptoms. The goal was to see if it might ease the burden of this challeng…

This study tested whether tesamorelin, a drug already approved for belly fat in HIV, could improve memory and thinking in 73 older HIV patients with mild cognitive problems. Participants also used a text-messaging app to stay motivated. The trial measured changes in brain perform…

This study tested a device that gently stimulates a nerve in the ear to see if it can improve thinking, sleep, and inflammation in older adults with frailty. Eighty people over 60 received either the active stimulation or a sham version, along with standard physical therapy, for …

This study tested a web-based program called Diapason for family caregivers of people with Alzheimer's disease. The program provides information, relaxation techniques, and a forum to connect with other caregivers. Researchers measured stress levels in 49 caregivers over 6 months…

This study looked at whether nicergoline, a drug that improves blood flow in the brain, can help people with swallowing problems caused by stroke, Parkinson's disease, or dementia. 92 adults were given either a low or high dose for 12 weeks. The goal was to see if swallowing impr…

This completed pilot study from Emory University tested whether a daily citicoline supplement could improve sleep quality, daytime sleepiness, and memory in 100 older adults with mild cognitive impairment (MCI). Participants took 1000 mg of citicoline for 3 months and completed s…

This study tested a hearing care program for older adults with both hearing loss and dementia. Speech-language pathologists delivered the program at home. The goal was to see if better hearing could reduce troubling symptoms like agitation and improve quality of life. 77 people t…

This study tested an online workshop for 109 family caregivers of people with dementia. The workshop taught caregiving skills and ways to manage stress and difficult emotions. The goal was to see if the workshop was easy to use and helpful for caregivers, with the hope of improvi…

This study tested a smartphone app called Compas-Y, designed to help people with cancer manage emotional distress through self-compassion exercises. 28 adults who had finished cancer treatment and felt low well-being used the app for 6 weeks. Researchers measured changes in self-…

This study tested whether caregivers prefer a fast-dissolving memantine tablet (Sinolvir®) or the standard tablet (Eutebrol®) for people with moderate to severe Alzheimer's disease. About 105 patients took one form daily for two months, and their primary caregivers filled out a s…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study tested a traditional Chinese medicine capsule called SaiLuoTong (SLT) in 493 adults aged 40-75 with mild to moderate vascular dementia. The goal was to see if SLT improves thinking, memory, daily activities, and behavior compared to a placebo. The trial lasted 52 weeks…

This study tested a device that plays soft sounds during deep sleep to help memory in people with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's. 37 participants received either real or silent (placebo) sounds while sleeping. Researchers me…

This pilot study tested a 6-session virtual program called MASC that teaches mindfulness, self-compassion, and behavior management skills to caregivers of people with Alzheimer's or related dementias. 82 caregivers participated to see if the program is feasible and acceptable. Th…

This study tested a mobile app designed to support informal caregivers of people with dementia. Researchers wanted to see if the app could reduce caregiver burden, improve quality of life, and help manage neuropsychiatric symptoms in the person with dementia. 75 caregivers partic…

This study tested a 4-week oral health program for 64 older adults with dementia at a day care center. The program included guided mouth exercises and daily brushing. Researchers measured changes in oral hygiene and function to see if the program could help.

This study looked at whether combining acupuncture and acupressure can improve thinking, independence, mood, sleep, and pain in elderly people with mild to moderate dementia. About 236 people aged 65 and older from nursing homes took part. They received either routine care, acupu…

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested a 10-week remote nursing program for family caregivers of people with early-stage Alzheimer's dementia. Caregivers used a website called 'Take Care of Yourself' to access training modules and support. The goal was to see if this approach could reduce caregiver b…

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ provide companionship and personalized activities to people with dementia living at home. The program was delivered virtually over 12 weeks. Researchers measured changes in mood, quality of life, a…

This study tested a non-invasive electrical stimulation device on the scalp in 80 adults aged 50+ with mild cognitive impairment. Participants learned word pairs while receiving either real or sham stimulation. Their memory was tested right after, and again at 7 and 28 days. The …

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested whether a digital program called Sleepio, which provides cognitive behavioural therapy for insomnia, could be used by people with mild cognitive impairment or mild dementia. Thirty participants were enrolled to see if the program was acceptable and easy to use. …

This study tested a web-based app called Gotcha! designed to help people with mild-to-moderate dementia remember names of people they know. 48 participants practiced daily for 6 weeks using a tablet at home. The goal was to see if the therapy improves name recall and whether it c…

This study tested whether a procedure called a stellate ganglion block (SGB), given with standard medication, could improve thinking and memory in people with Alzheimer's disease. Forty participants were randomly assigned to receive either SGB plus standard drugs or standard drug…

This study tested a Danish support program called DemTool for family caregivers of people with dementia. The program included group sessions and educational materials to help caregivers cope and reduce stress. Researchers measured changes in caregiver distress and overall health …

This study tested a program where home-care nurses were trained to support people with dementia in making their own everyday choices, with help from family caregivers. 12 people with dementia, 14 caregivers, and 33 nurses took part. Most found it helpful, but the program was time…

This study involved 61 people with early-stage dementia and their caregivers. Researchers worked with participants to create a personalized plan of meaningful activities, designed to adapt as the disease progresses. The goal was to see if this approach could improve thinking skil…

This study tested whether a special pain scale called PAINAD, built into the electronic health record, helps emergency room staff better assess and treat pain in older adults with dementia who come in with hip pain. The study included 714 patients and measured how often the scale…

This study tested whether doing paper-based cognitive training (like memory and attention exercises) could help 70 Vietnamese patients with early Alzheimer's disease. Participants did the training for 12 weeks, and researchers measured changes in memory, thinking, and daily livin…

This study tested a mobile app designed to help people who care for a family member with dementia. 59 caregivers in Singapore used the app for one month or were placed on a waiting list. The goal was to see if the app could reduce feelings of depression and burden, and improve kn…

This study tested a program called ABC ANSWERS for veterans with Alzheimer's disease or traumatic brain injury and their informal caregivers (family or friends). The program added extra support and education to regular primary care. Researchers measured changes in quality of life…

This study tested a medicine called BXCL501 for calming sudden episodes of agitation in people with dementia. It involved 151 participants who took the medicine only when needed over 12 weeks. The goal was to see if it safely reduces severe restlessness, tension, or aggression.

This study tested if weighted blankets can help reduce agitation and other behavioral symptoms in people with dementia. Researchers observed 30 patients in hospital or hospice settings. The goal was to see if a simple, non-drug approach could improve comfort and calmness.

This study tested a new exercise device called FitMi AD in 31 people with mild cognitive impairment or mild dementia due to Alzheimer's. The device uses sensors to track movements while users follow exercises shown on a computer screen. Researchers measured improvements in balanc…

This study tested a six-month exercise program that combines acupunch (a gentle punching routine) with SPOZ technology in 142 older adults with dementia. The goal was to see if it could improve thinking, memory, and behavior problems. Participants were 65 or older and attended ad…

This study tested a six-month exercise program that combines acupunch moves with SPOZ technology in 142 older adults with dementia. The goal was to see if it could improve balance, strength, and daily living skills. Participants did the program at adult daycare centers, and resea…

This study tested a distance-learning program for family caregivers of people with Alzheimer's dementia or traumatic brain injury. The goal was to reduce care-resistant behaviors like agitation and aggression, and improve quality of life for both patients and families. 88 caregiv…

This study tested an online program called LEAF that teaches positive emotion skills to family caregivers of people with Alzheimer's. 386 caregivers were randomly assigned to a Zoom group, a self-guided group, or a control group. The goal was to see if learning these skills could…

This study tested a support program called TACSI for people caring for a family member with both traumatic brain injury and dementia. The program included coaching and education to help caregivers manage stress and improve communication. Researchers measured changes in caregiver …

This study tested a virtual reality program designed to help family caregivers of people with dementia. 92 caregivers in Taiwan used VR to experience dementia symptoms, alongside e-books and support groups. The goal was to improve their knowledge, empathy, and confidence while re…

This study tested whether special snacks that change texture in the mouth could help improve nutrition in people with dementia. Ten participants living at home tried these snacks for a period of time. The goal was to see if the snacks were safe, acceptable, and easy to eat, with …

This study tested a new, drug-free approach to help older adults with mild cognitive impairment or Alzheimer's disease. The method combined gentle electrical brain stimulation, cognitive training, and near-infrared light therapy delivered through the nose. The goal was to see if …

This study tested whether hearing aids can improve thinking, daily behavior, and quality of life in people with mild to moderate Alzheimer's disease who also have age-related hearing loss. Fifty-one participants were split into two groups: one got real hearing aids for 12 months,…

This study tested a special palliative care program for people with late-stage Alzheimer's or related dementias and their family caregivers. The program started during a hospital stay and included caregiver education and support to reduce hospital transfers and improve symptom co…

This study tested a mobile health program designed to support family caregivers of people with both dementia and diabetes. The program added weekly online support and resources to standard home visits. Researchers measured changes in caregiver burden and social support after 12 w…

This study tested whether gentle reminders (nudges) to doctors and caregivers could help reduce risky medications in people with dementia. Researchers enrolled 250 patients and their primary care providers. The goal was to see if this approach is practical and can be measured in …

This study looked at whether two specific diets—the ketogenic diet and the Therapeutic Lifestyles Changes diet—could improve thinking and memory in people with Alzheimer's disease. Researchers measured changes in cognitive test scores over three months in 84 adults aged 50 to 90 …

This study tested whether daily singing of personally meaningful songs can boost memory and language in people with Alzheimer's disease or mild cognitive impairment. One hundred participants worked with a music therapist and sang a 'song of kin' at home for 12 months. Researchers…

This study looked at whether a long-term exercise program can help people with dementia living in nursing homes keep their ability to do daily tasks like bathing and dressing. 140 participants were split into an exercise group and a social activity group. The goal was to see if e…

This study tested a program where care partners helped people with mild dementia brush their teeth better. The program included a personalized oral care plan and tips for communication and cueing. Researchers measured plaque and gum health in 60 participants. The goal was to prev…

This pilot study tested whether combining a mild brain stimulation technique (tDCS) with intensive language therapy can help people with non-fluent aphasia after a stroke. Ten participants received both real and sham stimulation during therapy sessions. The goal was to see if the…

This study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …

This study looked at the long-term safety and effectiveness of a drug called AXS-05 for treating agitation in people with Alzheimer's disease. A total of 456 participants who had already been in earlier studies took part. The goal was to see if the drug could safely reduce agitat…

This completed study tested a smart electric vehicle designed to detect and improve walking problems in 120 people aged 60-85 with Parkinson's disease or dementia. The vehicle uses artificial intelligence to monitor gait, provide feedback, and assist with balance. The main goal w…

This pilot study tested whether a dietary supplement called citicoline could improve sleep and cognitive function in 20 people with Alzheimer's disease. Participants took either citicoline or a placebo for 3 months, and researchers measured sleep quality, daytime sleepiness, and …

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale…

This study tested a video-based program called STELLA-FTD to help family caregivers of people with frontotemporal dementia (FTD). Sixteen caregivers participated in the program, which aimed to reduce their stress and improve their quality of life. The approach used videoconferenc…

This study tested a smart cloth care system for people with dementia living at home. The system includes a vest with a hidden monitor and home sensors that send information to family caregivers. Researchers wanted to see if it could improve safety, daily function, and caregiver w…

This study tested an upgraded smart cloth system that people with dementia wear 24/7 to monitor activity, falls, and nighttime restlessness. The system sends alerts and weekly summaries to family caregivers through an app. The goal was to see if it helps caregivers feel more prep…

This study looked at whether doing physical and mental tasks at the same time (dual-task training) can help people with mild to moderate Alzheimer's. 34 participants completed the program. The goal was to see if this training could improve balance, reduce fear of falling, boost t…

This study tested whether a daily supplement called ETAS®, made from asparagus, could improve memory, mood, and reduce inflammation in healthy adults aged 60-80 who had mild memory concerns. 45 participants took either a low or high dose of ETAS® or a placebo for 12 weeks. Resear…

This study tested speech entrainment therapy (SET) in 80 people with non-fluent aphasia after a stroke. Participants practiced speaking along with an audio-visual computer program for 3, 4.5, or 6 weeks, or received no therapy. The goal was to find the best duration for lasting i…

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS, combined with language therapy, could improve speech in 23 people with primary progressive aphasia (PPA). Participants received either real or fake (sham) stimulation daily for 10 days. Rese…

This study tested whether music therapy can prevent hospital-related confusion (delirium) in people with Parkinson's disease or Lewy body dementia. 30 hospitalized adults took part, receiving either music therapy sessions, self-directed music listening, or standard care. Research…

This study tested a home device called Care4AD (Nili) designed to help caregivers coordinate daily activities for people with Alzheimer's or related dementia. The device provided reminders for tasks, social engagement, and medication. Researchers measured changes in caregiver bur…

This completed trial tested a virtual program for people with Alzheimer's or related dementias and their caregivers. Nearly 1,000 participants received monthly video or phone visits from nurses or social workers over a year. The program focused on managing symptoms, reducing care…

This study tested whether a brief, personalized activity or care routine (called IPPI) is feasible for nursing home residents with dementia who also show signs of distress or depression. Care partners delivered two short sessions per week for six months. The goal was to see if th…

This study tested whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory and thinking problems. Twenty-five participants took either the drug or a placebo daily for one year. The main goal was to check safety and tolerability, wi…

This completed study tested an online platform called LifeBio Memory that helps collect life stories from people with dementia. The platform uses machine learning to turn spoken memories into personalized storybooks. Researchers wanted to see if this tool could improve mood, redu…

This study tested a program called SHARP-CG for older Black caregivers of people with dementia. Caregivers, their loved ones with dementia, and a support person walked together while using a tablet to look at old neighborhood photos and talk about memories. The goal was to see if…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study tests whether an 8-hour digital learning program using virtual reality (VR) and augmented reality (AR) can improve dementia care knowledge, attitudes, and teamwork among long-term care professionals. About 150 staff from 12 care institutions in Taiwan take part, with s…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This completed Phase 2 study tested whether a special PET scan using a tracer called UCB-J can measure synaptic density—the connections between brain cells—in people with Alzheimer's disease. Researchers scanned 100 participants across different stages, from healthy to dementia, …

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study looked at the experiences of 275 extended family members (like grandchildren, siblings, and nieces/nephews) who care for a person with dementia. Researchers interviewed caregivers about their daily tasks, stress, and use of support services. The goal is to us…

This study measured the activity of an enzyme called glucocerebrosidase in 236 people with and without Lewy body dementia. The goal was to see if lower enzyme activity could help identify patients who might benefit from treatments already used for Gaucher disease. The study did n…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study tested a 6-week museum-based programme called 'Refresh and Reconnect!' for older adults with mild cognitive impairment or mild dementia. Participants took guided tours and joined artist-led activities like dance, art, or drama. Researchers measured changes in quality o…

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia. Researchers monitored 14 participants' movements and behaviors in real-life situations. The goal was to see if technology could provide a more objective way to a…

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study looked at whether regular exercise can help slow down memory and thinking problems in older adults with early Alzheimer's disease and in healthy older adults. Researchers tested a program combining aerobic and strength exercises against stretching and balance exercises…

This pilot study tested whether a virtual reality reaction time test can help predict fall risk and cognitive decline in older adults with memory problems. Twenty participants aged 65 and older with cognitive impairment completed a VR task and standard tests. The goal was to see …

This study examined whether older adults with disrupted sleep or irregular daily rhythms show early brain changes linked to Alzheimer's disease. Researchers used wrist-worn activity monitors and brain MRI scans in 47 people over 65 without major memory problems. The goal was to s…

This study looked at 30 healthy older adults to see if changes in a small brain area called the locus coeruleus could be an early sign of Alzheimer's disease. Researchers used brain scans, sleep tests, and spinal fluid analysis to measure brain function, sleep quality, and attent…

This study looked at whether a partnered dance program (adapted tango) could improve inflammation, memory, and mood in African-American women who care for a family member with Alzheimer's disease. Fifty women between 45 and 65 years old took part. Researchers measured changes in …

This study tested whether a lifestyle program delivered through a smartphone app could help older adults (ages 60-77) at risk for dementia. 156 participants in four countries were split into two groups: one received a structured program with app support and in-person sessions, wh…

This study looked at whether a case management program called PartnerED could help reduce unnecessary hospital stays for people with Alzheimer's disease living in assisted living facilities. Researchers worked with care managers who gave emergency room doctors real-time informati…

This study tested whether a tool inside a patient portal could help people with mild memory problems discuss and document their future healthcare wishes. Researchers enrolled 300 older adults with cognitive impairment who had a patient portal account. The goal was to see if peopl…

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study used special brain scans (SPECT imaging) to look at two key brain chemicals—acetylcholine and dopamine—in people with dementia with Lewy bodies. Researchers aimed to see if differences in these chemicals could help diagnose the disease and identify subtypes. The study …

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at brain scans of 304 retired farmers aged 65 and older living in rural France. None had memory complaints at the start. Researchers used MRI and PET scans to measure brain areas linked to Alzheimer's, like the hippocampus. The goal was to find very early imagin…

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye changes could serve …

This completed trial tested an online tool called 'Safety in Dementia' that guides caregivers through decisions about firearm access for a person with dementia. 500 informal caregivers across the U.S. participated. The tool helps clarify options, risks, and personal values, aimin…

This study looked at how older adults with and without Alzheimer's disease move in time with music. Researchers wanted to understand if this rhythmic movement relates to emotional expression and communication. The study involved 240 participants and measured how accurately they t…

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This completed study looked at 344 frail older adults (70+) with memory issues to see how many have Alzheimer's-related brain changes. Participants had MRI and PET scans to detect amyloid plaques. The goal was to understand the link between frailty, memory loss, and Alzheimer's p…

This study checks whether a questionnaire called SCREEN can accurately find nutrition risk in older adults (55+) who have mild cognitive impairment or dementia and live at home or in retirement homes. Researchers will compare SCREEN results to a dietitian's assessment and test if…

This completed study at Rutgers University looked at how the brain and body communicate in 30 people with conditions like autism, ADHD, Alzheimer's, and Parkinson's. Participants performed natural movements like walking and pointing while their brain, heart, and motion signals we…

This study tested two training programs (in-person and online) for staff in long-term care facilities in Minnesota. The goal was to improve care for LGBTQ+ residents with Alzheimer's or other dementias. Over 700 staff members participated, and researchers measured changes in poli…

This study looked at whether cochlear implants, which help restore hearing, can also improve thinking and memory in adults aged 65 and older with hearing loss. Researchers gave 37 participants a series of cognitive tests before surgery and again at 6 months, 12 months, and 5 year…

This small study tested whether a nurse-led walking and sit-to-stand program is practical and liked by older adults with cognitive issues like dementia who are in transitional care after a hospital stay. Six people took part, and the researchers measured how many joined, stayed, …

This study tested a program called Promoting Positive Care Interactions (PPCI) in assisted living facilities. The goal was to see if it's feasible and acceptable to train staff—like nurses and housekeepers—to improve daily interactions with residents who have Alzheimer's or relat…

This study tested a program called Alianza Latina to improve dementia care for older Latinos. Researchers trained primary care doctors to better detect and treat dementia, and provided bilingual health navigators to help patients and their caregivers. The study involved 243 parti…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study looked at how older adults, including those with Alzheimer's or mild cognitive impairment, make decisions about where to live as they age. Researchers followed 293 participants to understand what factors—like memory, health knowledge, and support from family—influence …

This study looked at whether self-compassion (being kind to yourself) is linked to better quality of life in older adults recently diagnosed with dementia. Researchers also checked if feeling threatened by dementia affects this relationship. 23 participants aged 65 and older, dia…

This completed study looked at over 11,000 adults in Trøndelag, Norway, to find out how many people have dementia and how many are undiagnosed. Researchers used standard tests to measure memory and thinking skills. The goal is to get a clearer picture of dementia rates across Nor…

This Norwegian study followed 169 elderly patients with depression for three years to see how they fared after specialist treatment. Researchers tracked whether depression returned or became chronic, and also checked for signs of dementia. The goal was to better understand the lo…

This completed study involved over 2,200 people diagnosed with or suspected of having frontotemporal dementia (FTD). Researchers collected blood samples to look for genetic changes linked to the disease. The goal was to find out how common these genetic causes are in people with …

This study tested a training program for home care workers who care for people with dementia. The program used realistic scenarios to help workers build empathy, feel more prepared, and improve their caregiving skills. 70 full-time home care workers took part, and the study measu…

This study tested a program called PorchLight Project, where trained senior companions helped families caring for someone with Alzheimer's or dementia. The goal was to connect families with community services and improve their interactions with doctors. Researchers measured thing…

This study tested whether a community health worker (CHW) can help people with dementia and their family caregivers after a hospital stay. The CHW provided education, care planning, and support through home visits and phone calls. The goal was to see if the program was feasible a…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study tested a program called Patient Priorities Care in 178 people with dementia or mild cognitive impairment. Participants received a packet before their clinic visit and could talk with a trained facilitator about their personal healthcare goals. The study aimed to see if…

This study used brain imaging and memory tests to find early signs of Alzheimer's disease. Researchers followed 242 volunteers, including healthy young, middle-aged, and older adults, to track changes over time. The goal was to understand how the disease develops and identify mar…

This study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study followed 44 adults with a confirmed VCP gene mutation to learn how their disease (IBMPFD) naturally progresses over one year. Participants completed walking tests, strength assessments, and surveys about daily function and quality of life. The goal was to gather data t…

This study looked at sleep disturbances in people with Alzheimer's disease. Researchers tracked sleep diaries, activity levels, and behavior in 70 participants to understand how disrupted sleep relates to daily cycles and daytime alertness. The goal was to learn more about the li…

This study tested a program that screens older adults (60+) for memory and thinking problems after they leave the intensive care unit (ICU). The goal was to see if it's possible to identify issues like mild cognitive impairment or dementia early. 109 people took part, and the stu…

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …

This study tested whether an AI platform can detect mild cognitive impairment and early dementia by analyzing people's speech. Researchers compared language patterns from speaking tasks with standard memory and thinking tests in 196 older adults. The goal was to see if speech cha…

This study aimed to create a communication tool to help people with Alzheimer's or dementia and their caregivers discuss and plan for future medical care. Researchers worked with 38 participants to see if the tool improved their readiness to make advance care plans. The goal was …

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This completed study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements in 48 participants to understand which attention and memory processes are impaired. The goal was to link visual expl…

This study tested whether a focused ultrasound device can safely and temporarily open the blood-brain barrier in 20 people with mild-to-moderate Parkinson's disease dementia. The goal was to see if the procedure is safe and feasible, not to treat the disease itself. Researchers m…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study tested whether a gentle electrical current applied to the scalp at 40 Hz can strengthen brain rhythms linked to memory in healthy adults aged 50-80. Thirty participants received the stimulation while performing a working memory task. The goal was to see if this approac…

This study tested whether combining two non-invasive brain stimulation techniques (tACS and iTBS) can enhance gamma brain waves and working memory in 30 healthy adults. The goal is to develop better stimulation protocols that could one day help people with Alzheimer's disease. Pa…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This study tested a new version of a common memory test (MMSE) that is adapted for people in Réunion Island, especially those who cannot read or write well. Researchers compared the new test with the standard French version in 61 hospitalized older adults. The goal was to see if …

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This completed study measured levels of two substances (IGF-I and IGFBP-3) in the blood of 693 older adults: some with Alzheimer's disease, some with mild cognitive impairment, and some with normal memory. The goal was to see if these levels differ between groups and relate to th…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study looked at whether measuring the skin's electrical activity can warn of agitation or aggressive behavior in people with dementia. 21 patients from a dementia unit took part. The goal was to see if a warning signal appears before an outburst, which could help caregivers …

This study looked at whether bowel cleansing before colorectal surgery is linked to memory or thinking problems after the operation. Researchers measured certain brain-related proteins in the blood and gave thinking tests to 84 patients before and after surgery. The goal was to u…

This study followed 404 older adults for 10 years after hip fracture surgery. Researchers checked whether early signs of Alzheimer's in spinal fluid or cognitive tests were linked to how long patients lived. The goal is to understand if hidden Alzheimer's changes affect long-term…

This study followed 544 older couples (ages 65+) over three years to see how dementia affects their relationship and well-being. Both partners answered surveys every six months about their mental health, physical health, and caregiving experiences. The goal was to learn how being…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This study looked at health records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the …

This study tested whether a medication used for sleep can boost the brain's natural waste-clearing system, called the glymphatic system, in healthy older adults. The goal was to see if this approach could help remove harmful proteins linked to Alzheimer's disease. Thirty-one part…

This study tested whether a virtual reality (VR) program could help older adults with mild cognitive impairment learn more about dementia and improve their health skills. 139 participants aged 65 and older were split into two groups: one used a VR health education module, and the…

This study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…

This study tested whether mailing educational materials to caregivers of people with Alzheimer's could reduce the use of risky medications like sedatives and antipsychotics. Over 11,000 older adults with Alzheimer's took part. The goal was to see if this simple approach could mak…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This study tested a new approach to help people with dementia and their caregivers reduce unnecessary medications. Researchers compared patients who received care focused on their personal health priorities to those who got usual care. The goal was to see if this method leads to …

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This study tested whether time-restricted eating (eating only during certain hours of the day) could improve blood vessel health and brain function in older adults at risk for age-related memory decline. Researchers measured changes in brain blood flow and electrical activity in …

This study tested a web-based program called Structured Retrieval Practice (SRP) to help dementia caregivers learn and remember practical care skills. 73 caregivers completed online modules and quizzes. The goal was to see if this method improves knowledge retention and reduces c…

This study tested whether a learning technique called retrieval practice (using quizzes) helps caregivers of people with dementia better remember information about symptoms and treatments. 65 informal caregivers in the US took part. The goal is to improve caregiver education and …

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This completed study followed over 6,000 Medicare patients with memory problems to see if a special brain scan (amyloid PET) helps doctors make better care decisions. The study included a diverse group of participants to ensure findings apply to everyone. It did not test a new dr…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study looked at whether people with mild cognitive impairment or Alzheimer's-type dementia can understand and decide about receiving their PET scan results for amyloid and tau proteins. Researchers educated 152 participants and their care partners, then assessed their abilit…

This completed study looked for chemical markers in blood and urine that could help detect Alzheimer's disease early. Researchers analyzed samples from 95 people with mild cognitive impairment or Alzheimer's, comparing them to healthy older adults. The goal was to find biomarkers…

This study tested a program where a care coordinator helps people with Alzheimer's and their caregivers manage doctor visits, medications, and support. Over 2,000 people took part to see if this approach reduces emergency room visits and delays nursing home stays. The goal was to…

This completed study investigated whether a variation in the CR1 gene makes people more likely to develop Alzheimer's disease. Researchers compared 200 Caucasian participants—some with Alzheimer's and some without—to see if the gene difference is a risk factor. The study did not …

This early-stage study tested the safety of a new drug called NH280105 in 32 healthy adults. Researchers gave single and multiple doses to see if it causes side effects and how the body processes it. This is a first step to see if the drug is safe enough to test in people with Al…

This study tested whether an online platform can effectively share Alzheimer's gene and biomarker test results with 681 participants, compared to a video call with a healthcare provider. The goal was to see if the self-guided method causes similar levels of anxiety, distress, and…

This pilot study tested a new online program called the Brain Health Support Program (BHSP) designed to teach people about dementia and how to lower their risk through lifestyle changes like diet, exercise, and social connection. Twenty adults with mild memory concerns or a famil…

This study tested a special training and tool for home hospice nurses and social workers to help them better care for people with dementia and support their families. About 93 participants, including clinicians and family caregivers who are Black or White, took part. The goal was…

This completed study analyzed blood samples from 120 athletes and patients with a history of repeated mild head injuries, along with healthy volunteers. Researchers used advanced genetic and protein analysis to find markers in the blood that could signal chronic traumatic encepha…

This study interviewed 26 adults who either have behavioral variant frontotemporal dementia (bvFTD) or carry a gene that puts them at risk. The goal was to learn how the condition affects daily life, emotions, and coping. No treatment or medication was tested—just listening and g…

This completed study followed 378 people with moderate-to-severe Lewy body dementia and their caregivers for up to three years. Researchers collected surveys and some physical exams to track symptoms, caregiver stress, and quality of life. The goal was to find clues that signal w…

This study tested whether a single virtual reality (VR) session, where caregivers experience what it's like to have dementia, could improve their empathy and attitudes. 227 caregivers of people with dementia took part. The results showed that the VR session helped caregivers bett…

This study tested whether showing videos about care options to hospitalized patients aged 65 and older, or those with dementia, helps them make better advance care plans. Over 11,000 patients took part at two hospitals. The goal was to see if these video discussions lead to more …

This study tested whether daily paced breathing combined with brain training games could improve attention, memory, and reduce Alzheimer's-related markers in healthy adults aged 50-70. Participants did brain training and paced breathing at home for 10 weeks, and provided blood an…

This completed study tested a new radioactive tracer called [18F]-SynVesT-1 to measure brain synapse density in 134 people with Alzheimer's disease, frontotemporal degeneration, dementia with Lewy bodies, or late-life psychiatric disorders. Researchers compared this new scan to t…

This study looked at whether giving doctors educational materials about a new blood test for Alzheimer's disease helps them make better care decisions. 178 neurologists and dementia specialists in the US participated in virtual patient cases. The researchers measured changes in d…

This study tested whether two types of belly-focus meditation, practiced 40 minutes daily for a week, could change blood markers linked to Alzheimer's disease in healthy adults aged 18-35. Participants provided blood samples and completed memory tests before and after the meditat…

This study tested a phone app called MEMI designed to help adults with chronic traumatic brain injury improve their memory. Forty participants used the app to practice remembering words through spaced retrieval exercises. The main goal was to see if the app was easy to use and ac…

This study gathered test results from 1,300 healthy adults aged 50 and older to create a reference database for a quick, tablet-based brain function test called BrainCheck. The goal was to establish normal score ranges and check if the test gives consistent results over time. No …

This study looked at whether doing memory and thinking tests over a video call at home works as well as doing them in person for people with suspected Alzheimer's disease. 116 older adults (ages 60-90) with mild memory problems took part. The goal was to see if video assessments …

This study looked at medical records of 683 older adults with dementia to see if their use of antiplatelet drugs (like aspirin) matched official guidelines. Researchers found that prescribing patterns varied across different types of dementia. The goal was to understand real-worl…

This study tested an 8-week group program called My Healthy Brain for older adults with memory concerns and lifestyle risk factors for dementia. The program, delivered via Zoom, taught mindfulness and behavior change skills to help participants improve exercise, sleep, diet, and …

This completed study looked at whether using adult day services helps reduce stress in Black caregivers of family members with dementia. Forty-two caregivers provided saliva samples and filled out stress surveys on days when their loved one used adult day services and on days the…

This study surveyed 219 family caregivers of people with dementia to explore how swallowing problems (dysphagia) affect their burden and needs. Caregivers completed a one-time online questionnaire about their experiences, stress, and knowledge. The goal is to better understand an…

This study looked at cells from 21 people with BPAN, a rare brain disease caused by a gene mutation. Researchers wanted to see if the cells have trouble handling stress, which might explain why brain cells die. No treatment was given; the goal was simply to learn more about the d…

This completed study followed 229 stroke survivors over time to understand what factors might lead to dementia or cognitive problems after a stroke. Researchers looked at medical history, brain scans, and medications. The goal was to identify clues that could help predict and pos…

This pilot study gave the BCG vaccine (used for tuberculosis) to 20 healthy older adults aged 55-80. Researchers measured changes in immune markers and Alzheimer's-related proteins in blood and spinal fluid over 90 days. The goal was to see if this common vaccine might influence …

This study tested a program called APPROACHES in nearly 500 nursing homes across the U.S. The program trained staff to better discuss and document care preferences for residents with Alzheimer's or related dementias. The goal was to see if this approach could reduce unwanted hosp…

This completed study involved 100 adults aged 50-80 who gave blood samples weekly for 9 weeks. Researchers measured a protein called pTau-217, which is linked to Alzheimer's disease. The goal was to see how much this biomarker naturally fluctuates from week to week, which could h…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study looked at driving skills in 60 people over age 70 with early-stage Alzheimer's disease (MMSE score 24 or higher) and compared them to healthy older drivers. The goal was to identify common driving mistakes and suggest adaptive measures or technology to help them drive …

This study exposed 40 healthy, non-smoking adults to diesel exhaust and clean air to see how pollution affects the olfactory system (the part of the nose that detects smells). Researchers took biopsies from the nose and tested thinking and smell abilities. The goal is to understa…

This study used powerful MRI scans to track how a rare genetic disease called metachromatic leukodystrophy (MLD) damages the brain's white matter in young children. Researchers studied 29 children aged 1 to 6 years with MLD, along with a control group, to better understand how th…

This study tested a special PET scan tracer (F-18 AV 1451) to see how much tau protein builds up in the brains of 81 people with primary progressive aphasia or frontotemporal dementia. Researchers compared these scans to those of healthy controls to find unique patterns for each …

This study adapted a Canadian safety checklist for use in France to help caregivers assess accident risks for elderly people with dementia living at home. Researchers worked with 116 caregivers to test the checklist's reliability. The goal is to give healthcare providers a simple…

This study tested a virtual reality (VR) education program for 200 nursing students in Indonesia. The program uses videos, VR experiences, and discussions to help students learn about dementia and improve their attitudes toward people living with it. Researchers measured changes …

This study tested a program to support families right after a dementia diagnosis. 82 caregivers from Iowa took part. The program provided education and help connecting to community services. The goal was to reduce caregiver burden and improve knowledge of available support.

This study looked at how giving people information about their genetic risk for Alzheimer's disease affects them emotionally and behaviorally. It involved 374 Latino adults aged 40-64 in New York City who did not have Alzheimer's. Some participants learned their risk based only o…

This completed study from the University of East Anglia looked at how gut bacteria break down certain plant compounds (flavan-3-ols) in people with different versions of the APOE gene, which is linked to Alzheimer's risk. 49 healthy adults donated stool and saliva samples. The go…

This study tested whether a 90-minute gaming-based education program could improve healthcare students' attitudes toward people with dementia. 400 students in Indonesia participated in the single-session program, which included a lecture, a gaming tool called N-impro, and short d…

This completed study looked at 40 people with spinocerebellar ataxia types 2 and 7, a rare brain disease that affects movement. Researchers used MRI scans and lumbar punctures over one year to track changes in the brain and body. The goal was to find reliable markers that could b…

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might li…

This study tested whether giving doctors tailored information about the benefits of community-based palliative care helps more people with dementia and their families accept it. Researchers worked with 301 Medicare Advantage members who were eligible for palliative care. The goal…

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…

This study looked at health records from over 800,000 older adults to see if certain blood pressure drugs (propranolol or carvedilol) are linked to a lower risk of dementia compared to other similar drugs (atenolol, bisoprolol, or sotalol). The goal was to find if repurposing exi…

This study tested whether a pharmacist-led program could help older adults with dementia and their caregivers reduce unnecessary medications. The program included an educational brochure, a telehealth visit with a pharmacist, and tailored recommendations for the patient's doctor.…

This study tested a computer program that helps primary care doctors identify older adults who might have early memory loss or dementia. Over 3,200 patients aged 65 and older took part. The tool uses information from electronic health records to flag patients who may need further…

This study tested whether a special planning program helps people with dementia in assisted living have their care wishes written down. Over 2,300 residents took part. The program aimed to increase the number of residents with do-not-resuscitate or do-not-hospitalize orders on fi…

This study looked at why people with Lewy body dementia often have sudden changes in alertness. Researchers tested if a brain chemical called acetylcholine is involved and if gentle brain stimulation could help. Fifteen participants took part to gather information for future trea…