Could a palm extract help fight a rare genetic brain disease?

This study tested a supplement called HOV-12020 (made from palm tocotrienols) in 50 adults aged 45-75 with CADASIL, a rare genetic disease that damages small blood vessels in the brain, leading to strokes and memory loss. The goal was to see if the supplement could reduce worsening of symptoms like stroke, disability, or cognitive decline over 24 months. Participants were randomly assigned to receive either the supplement or a placebo, and neither they nor their doctors knew which they received.