Could an old antibiotic help Parkinson's dementia?
NCT ID NCT03413384
First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times
Summary
This study tests whether the antibiotic ceftriaxone can improve thinking and memory in people with mild to moderate Parkinson's disease dementia. About 100 participants will receive either ceftriaxone or a placebo intravenously twice a week. The main goal is to see if ceftriaxone slows the decline in dementia symptoms over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ceftriaxone (an antibiotic given intravenously)
- What this could lead to
- If it works, this could point toward a new treatment to slow or improve dementia symptoms in people with Parkinson's disease.
- What could go wrong
- This is an early Phase 2 study with only 100 participants, so results may not be conclusive. Ceftriaxone is an antibiotic, not a standard dementia drug, and its effect on Parkinson's dementia is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Changhua Christian Hospital
Changhua, 500, Taiwan
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China Medical University Hospital
Taichung, Taichung, 404, Taiwan
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Chung Shan Medical University Hospital
Taichung, Taichung, 402, Taiwan
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Kaohsiung, 83301, Taiwan
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National Taiwan University Hospital
Taipei, Taipei, 100, Taiwan
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Taipei Veterans General Hospital
Taipei, Taipei, 11217, Taiwan