Gut bacteria and your genes: a new clue in Alzheimer's puzzle?
NCT ID NCT05905822
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study from the University of East Anglia looked at how gut bacteria break down certain plant compounds (flavan-3-ols) in people with different versions of the APOE gene, which is linked to Alzheimer's risk. 49 healthy adults donated stool and saliva samples. The goal was to see if gene type affects how gut microbes process these compounds, which could help explain why some people are more at risk for Alzheimer's.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dietary plant extracts (flavan-3-ols)
What this could lead to
If successful, this could point toward personalized dietary recommendations to reduce Alzheimer's risk based on a person's genes and gut bacteria.
What could go wrong
This is a small, completed lab study using stool samples, not a treatment trial. It only looks at how bacteria process compounds, not whether those compounds prevent or treat Alzheimer's.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ALZHEIMER DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Norwich and Norfolk University Hospital Clinical Research Facility
Norwich, Norfolk, NR4 7UY, United Kingdom