New drug ABBV-916 aims to slow Alzheimer's in early stages

NCT ID NCT05291234

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called ABBV-916 in people with early Alzheimer's disease. Participants received either the drug or a placebo intravenously every 4 weeks for 6 months, with an optional 2-year extension where everyone gets the drug. The goal was to check safety and whether the drug can reduce amyloid plaques in the brain, a hallmark of Alzheimer's.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-916 (an investigational drug given intravenously)
What this could lead to: If successful, ABBV-916 could slow the progression of early Alzheimer's disease by reducing amyloid plaques in the brain.
What could go wrong: This is a Phase 2 trial with only 106 participants, so results may not apply to everyone. The drug may cause side effects or fail to show meaningful benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE(AD)

Contacts and locations

Locations

Advanced Memory Research Institute of NJ /ID# 239533

Toms River, New Jersey, 08755-5043, United States
Allied Biomedical Res Inst Inc /ID# 244823

Miami, Florida, 33155, United States
Alzheimer's Research and Treatment Center - Stuart /ID# 245477

Stuart, Florida, 34997-5765, United States
Alzheimer's Research and Treatment Center - Wellington /ID# 245201

Wellington, Florida, 33414, United States
Artemis Institute for Clinical Research - San Diego /ID# 244508

San Diego, California, 92103-2204, United States
Aventura Neurological Associates /ID# 243892

Aventura, Florida, 33180, United States
Charter Research - Lady Lake /ID# 244657

Lady Lake, Florida, 32162, United States
Charter Research - Winter Park /ID# 244778

Orlando, Florida, 32803-1839, United States
ClinCloud - Maitland /ID# 244507

Maitland, Florida, 32751, United States
ClinCloud LLC - Viera/Melbourne /ID# 240635

Melbourne, Florida, 32940-8288, United States
Clinical Site Partners (CSP) - Orlando /ID# 245127

Winter Park, Florida, 32789-4681, United States
Clinical Trials of Texas, Inc /ID# 244917

San Antonio, Texas, 78229, United States
Columbus Memory Center /ID# 245054

Columbus, Georgia, 31909, United States
Conquest Research /ID# 243916

Winter Park, Florida, 32789, United States
Finlay Medical Research /ID# 245996

Miami, Florida, 33126, United States
Headlands Research - Orlando /ID# 239119

Orlando, Florida, 32819, United States
IMIC Inc. Medical Research /ID# 245900

Palmetto Bay, Florida, 33157, United States
Irvine Clinical Research /ID# 239469

Irvine, California, 92614, United States
JEM Research Institute /ID# 239122

Lake Worth, Florida, 33462-1141, United States
K2 Medical Research - Ocoee /ID# 246849

Ocoee, Florida, 34761-4547, United States
K2 Medical Research - Orlando - South Orlando Avenue /ID# 243919

Orlando, Florida, 32751, United States
Keystone Clinical Studies LLC /ID# 239973

Plymouth Meeting, Pennsylvania, 19462, United States
Merritt Island Medical Research /ID# 239495

Merritt Island, Florida, 32952-3616, United States
Neurology Associates Ormond Beach /ID# 245527

Ormond Beach, Florida, 32174, United States
Optimus U /ID# 245868

Miami, Florida, 33125-4013, United States
Pacific Research Network, Inc. /ID# 244083

San Diego, California, 92103, United States
Premiere Research Institute - Palm Beach /ID# 240108

West Palm Beach, Florida, 33407-3209, United States
QUEST Research Institute /ID# 239459

Farmington Hills, Michigan, 48334-2977, United States
Re:Cognition Health - Fairfax VA /ID# 239501

Fairfax, Virginia, 22031-5207, United States
Renstar Medical Research /ID# 240153

Ocala, Florida, 34470, United States
Syrentis Clinical Research /ID# 239682

Santa Ana, California, 92705, United States
Tucson Neuroscience Research /ID# 244957

Tucson, Arizona, 85710-6152, United States

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