Dementia

This early-stage study tests a new vaccine called DUVAX in 24 healthy adults aged 40-65. The vaccine aims to train the immune system to attack two proteins linked to Alzheimer's disease. The main goal is to check safety and see if the vaccine produces a protective immune response…

This trial investigates whether a surgical procedure that connects lymph vessels in the neck to veins, combined with the standard drug donepezil, can slow cognitive decline in people with moderate Alzheimer's disease. The surgery aims to improve drainage of waste from the brain, …

This study tests whether a daily dose of tricaprilin, a type of fat that may provide energy to brain cells, can improve memory, thinking, and daily function in people with mild-to-moderate Alzheimer's disease. About 535 participants will receive either tricaprilin or a placebo fo…

This study tests whether a daily 240 mg dose of Ginkgo biloba extract can change certain blood markers linked to Alzheimer's disease in people with mild cognitive impairment. Over 6 months, 120 participants will be randomly assigned to receive either Ginkgo biloba or a placebo. T…

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure change…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests a surgical procedure called deep cervical lymphovenous anastomosis (LVA) for people with moderate Alzheimer's disease. The surgery aims to improve the brain's ability to clear waste proteins, like amyloid-beta, which are linked to Alzheimer's. Researchers will co…

This study tests a single intravenous dose of an experimental drug called CGB3002 in healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. This is a first step toward possibly developing a treatment for Alzheimer's disease.

This study tests a new nasal spray treatment for frontotemporal dementia (FTD), a brain disease that changes personality and language. The spray contains tiny particles from umbilical cord stem cells that may protect brain cells and reduce harmful protein buildup. About 33 adults…

This Phase 3 trial tests whether a daily injection of GV1001 can slow cognitive decline in 750 people with moderate-to-severe Alzheimer's. Participants will receive either the drug or a placebo for 24 weeks. Researchers will measure changes in thinking, memory, and daily function…

This study tests an oral medication called Gut-X-001 in 120 people with Alzheimer's disease. The goal is to see if it can improve thinking, daily living skills, and brain health. Participants will receive the drug or a placebo for 6 months, with an option to continue for another …

This study tests whether MLC901 (NeuroAiD™II) can improve thinking and memory in people with mild to moderate Alzheimer's disease. About 350 adults aged 50 and older will receive either the study drug or a placebo for several months. Researchers will measure changes in cognitive …

This early-stage trial tests whether lithium orotate, a form of the mineral lithium, is safe and reaches the brain in people with early Alzheimer's. Forty adults with confirmed Alzheimer's will take either the supplement or a placebo for 9 weeks. Researchers will measure lithium …

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

The EMBRACE trial will test whether a 12-month program combining Mediterranean diet advice, cognitive and language training, physical activity, and financial/digital literacy can help older adults at risk of cognitive decline. 120 participants will be randomly assigned to the pro…

This study tests a drug called TML-6 in 210 people with early Alzheimer's disease. Over 52 weeks, researchers will compare those taking TML-6 to those on a placebo to see if the drug can slow or stop memory and thinking problems. The goal is to find a treatment that helps people …

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This early-phase trial will test whether a special form of resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for three months. The study will also measure how the drug …

This early-stage study tests whether a focused ultrasound can safely and temporarily open the brain's protective barrier in people with early Alzheimer's disease. The goal is to see if this helps clear harmful amyloid and tau proteins that build up in the brain. Six participants …

This early-stage study tests whether a nasal spray containing particles from neural stem cells is safe for people with moderate-to-severe early-onset Alzheimer's. Nine participants aged 50-75 will receive different dosing schedules over 28 days. The main goal is to check for side…

This study tests whether donanemab, given as an IV infusion every 4 weeks, can safely lower amyloid plaques in the brains of 60 adults aged 35–50 with Down syndrome. Participants receive either donanemab or a placebo for 12 months, followed by a 12-month extension where everyone …

This study tests an experimental pill called RP902 in 360 people with mild cognitive impairment caused by Alzheimer's disease. Participants will take the drug or a placebo for 48 weeks to see if it slows memory decline. The trial is conducted at about 50 sites in China and may ex…

This pilot study tests whether a noninvasive ultrasound device can safely help clear waste from the brain in people at risk for Alzheimer's. Fifteen adults with signs of amyloid buildup will receive either real or sham ultrasound sessions over four weeks. The main goal is to chec…

This early-stage study tests a new drug called 8M2D for the first time in people. The goal is to see if it is safe and tolerable in healthy adults and in people with early Alzheimer's disease. Researchers will also check if 8M2D can lower amyloid beta, a protein linked to Alzheim…

This study tests whether low-dose radiation to the whole brain can slow down Alzheimer's disease in people with early-onset symptoms. Fifty participants will be randomly assigned to receive either the radiation treatment or a sham procedure. Researchers will track changes in memo…

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This study tests a vaccine called AADvac1 in 146 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and thinking. The vaccine aims to target a protein linked to the disease and slow its progression. Participants will receive injections o…

This Phase 2 trial tests whether the drug LM11A-31 can slow the progression of Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. About 147 people with early-stage PSP will receive either the drug or a placebo twice daily for several mo…

This study tests whether lecanemab, a drug that clears amyloid plaques in Alzheimer's disease, can also help people with Parkinson's disease who have amyloid buildup in their brains. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecanema…

This Phase 2 trial tests whether umbilical cord stem cells can safely improve movement and coordination in people with spinocerebellar ataxia (types 1, 2, 3, and 6). Forty-five participants will receive the cells through an IV and a spinal injection. The main goal is to see if sy…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of Alzheimer's disease by regulating the 'gut-brain axis'—the link between gut bacteria and the brain. Researchers will treat 200 Alzheimer's patients with either real or sham rTM…

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study tests whether drugs that target tau protein, alone or with donanemab, can reduce tau buildup and slow memory decline in people aged 50-80 with early Alzheimer's. Participants will receive treatment for 30 months and undergo brain scans and cognitive tests. The goal is …

This study tests a smartphone app called StrokeApp designed to support people after a stroke or mini-stroke. The app provides educational content, medication reminders, and tools to track health. Researchers will compare quality of life and other health measures between 500 patie…

This study will test whether a lower dose of the drug lecanemab works as well as the standard dose for people with early Alzheimer's disease. Researchers will compare brain scans, memory tests, and blood markers in 140 participants over 18 months. The goal is to find the most eff…

This Phase 1 trial tests a single injection of QLH2405 in 68 healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The main goal is to check safety and how the body processes the drug. It is too early to know if QLH2405 will help treat Alzheimer's.

This study tests whether a drug called DAOIB, which boosts brain signaling, combined with omega-3 fatty acids can improve thinking and daily life in people with early Alzheimer's or mild cognitive impairment. 140 participants will receive either the combo or a placebo for 24 week…

This study will test whether providing acute hospital care at home, instead of in a traditional hospital, can help people with moderate to severe dementia spend more days at home after an acute illness. Researchers will randomly assign 200 participants to either receive home-base…

This early-stage trial tests whether stem cells and their exosomes (tiny particles that help cells communicate) can safely improve movement in people with spinocerebellar ataxia, a condition that affects coordination and balance. Ninety participants will receive the treatment thr…

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This early-stage trial tests whether a minimally invasive neck surgery, called lymphaticovenular anastomosis (LVA), is safe for people with Alzheimer's disease. The surgery connects tiny lymph vessels in the neck to nearby veins, creating a detour to help the brain drain harmful …

This study tests whether a natural compound from soy, called genistein, can slow down memory and thinking problems in people with mild cognitive impairment (MCI), often an early sign of Alzheimer's disease. About 150 adults over 50 with MCI will take either genistein or a placebo…

This study tests a home-based dual-task training program for people with Parkinson's disease who have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while playing brain-training games on a tablet, three times a week for 3…

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either…

This early-stage trial tests whether repeated injections of a patient's own fat-derived stem cells into the brain are safe for people with mild to moderate Alzheimer's. Nine participants who previously received a single dose will now get up to six injections every two months. Res…

This Phase 1 trial tests a new drug called AK152 in healthy volunteers and people with Alzheimer's disease. The main goal is to check if it is safe and tolerable, and to see how the body processes it. The study is small and early-stage, so it will not prove whether the drug works…

This Phase 3 trial tests whether a daily supplement called tributyrin can slow cognitive decline in people with mild Alzheimer's disease. Over 12 weeks, 156 participants will take either tributyrin or a placebo. Researchers will measure changes in memory, thinking, gut bacteria, …

This Phase 3 trial tests whether masitinib, a drug that targets immune cells in the brain, can slow cognitive decline in 600 people with mild Alzheimer's. Participants take masitinib or a placebo alongside standard Alzheimer's medications. The study lasts 24 weeks and measures ch…

This Phase 2 trial tests whether repeated injections of a patient's own fat-derived stem cells into the brain can slow the progression of mild to moderate Alzheimer's disease. 115 participants will receive either the stem cells or a placebo every two months for a total of six dos…

This study tests whether oral semaglutide, a drug used for diabetes, is safe and can slow Alzheimer's disease. Sixty people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug protects brain cells.

This study tests a new device that uses mild electrical currents on the brain and virtual reality exercises to help people in the early stages of Alzheimer's disease. Researchers want to see if this approach can improve memory, thinking, and sense of smell. The study will involve…

This study tests a smartphone app called PRIMI that helps migrant women eat healthier and be more active after having a baby. The trial will include 200 women who recently gave birth and will use the app for six months. Researchers will measure diet quality and physical activity …

This phase 2 trial will test whether a nasal spray called NeuroEPO can help maintain thinking and memory in people with mild to moderate Alzheimer's disease. About 90 adults aged 50 and older will receive either NeuroEPO or a placebo three times a week for one year. Researchers w…

This study tests whether tadalafil, a drug typically used for erectile dysfunction, is safe and can help people with early Alzheimer's or mild cognitive impairment. Over one year, 244 participants will take either tadalafil or a placebo. Researchers will check for side effects an…

This study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…

This study will test the antibody drug lecanemab in 120 people with mild cognitive impairment or mild-to-moderate Alzheimer's disease. Using PET scans to measure amyloid and tau proteins in the brain, researchers hope to identify which patients are most likely to benefit from tre…

This study tests a French questionnaire designed to identify spatial orientation problems in people with Alzheimer's disease. Researchers will ask 330 participants—including Alzheimer's patients, their caregivers, and healthy older adults—to fill out the questionnaire. The goal i…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

This study will test a wearable headband called Somfit that measures brain activity during sleep in people with early or no Alzheimer's symptoms. Researchers want to see if it works as well as a full lab sleep test. If it does, it could make it easier to track sleep changes linke…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study tests a special PET probe that targets a protein called DDR2, which is linked to lung scarring in interstitial lung disease. Researchers will scan 50 patients to see if the probe can accurately detect the disease and also check for related cognitive problems. The goal …

This study tests a faster way to diagnose Alzheimer's disease using blood tests, spinal taps, and brain scans. It involves 200 people aged 50-90 with mild memory problems. The goal is to see if a nurse-led screening tool can help get a diagnosis in months instead of over a year.

This study will check if a blood test can find signs of Alzheimer's disease in people with early memory concerns. Researchers will test 1,000 adults aged 55 and older in primary care. The goal is to see if blood markers for amyloid and tau proteins match those found in spinal flu…

This study will check if a Greek version of the Montreal Cognitive Assessment (MoCA) test is reliable for spotting early memory problems. Researchers will enroll 250 Greek-speaking adults aged 55-85, including some with mild cognitive impairment or dementia. The goal is to give d…

This study will test if combining digital technology (analyzing how people walk, their facial expressions, and speech) with blood markers can better screen for early Alzheimer's disease in community adults aged 50 and older. The goal is to create a more efficient screening method…

This study looks at whether simple eye-tracking tests and brain scans can detect very early signs of Alzheimer's disease in 100 healthy older adults. Half of the participants carry a genetic risk factor (APOE4). The goal is to find biomarkers that could lead to earlier diagnosis,…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This study tests a 12-week remote program for adults aged 60-75 at risk of cognitive decline. The program includes aerobic exercise, cognitive training, and education on healthy aging, all delivered through a website. Researchers will measure whether the program improves memory, …

This pilot study will test whether teaching people aged 50 to 75 how to cook healthy meals can reduce their risk of type 2 diabetes and dementia. Forty participants at higher risk will either attend weekly cooking classes with at-home practice or receive nutrition handouts. The s…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether a year-long virtual lifestyle coaching program—focusing on diet, sleep, and activity—can lower Alzheimer's-related blood markers in 1,200 adults aged 60-80 who carry a genetic risk. Participants wear an Oura ring for tracking and provide blood samples. Th…

This study tests whether an AI-powered digital coach called BLAZE can help adults aged 40 and older improve their brain health. Participants will receive personalized tips and support through WhatsApp to reduce risk factors for dementia. The study will compare their progress to t…

This study tests an 8-week program called KINDER, designed to help family caregivers of people with dementia reduce psychological elder abuse and improve the quality of care. The program includes group discussions over Zoom and a self-paced workbook. Researchers will enroll 260 c…

This study tests whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults aged 60 to 79 who are at higher risk for Alzheimer's disease. Participants will be randomly assigned to either the exercise program or their usu…

This study tests whether the drug HT-4253 can lower Alzheimer's risk in people aged 50-75 who carry the APOE4 gene and have high levels of amyloid in their blood. The 112 participants will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug can …

This study tests whether a structured program of nutrition advice, physical exercise, brain games, social activities, and health monitoring can improve brain health in adults aged 60 and older who are at risk for memory problems. About 80 participants will either follow the full …

This pilot study tests whether a personalized lifestyle program combining workshops, remote coaching, and a smartphone app can help adults aged 55-75 at risk for dementia adopt healthier habits. 300 participants will either receive tailored guidance or standard advice. The main g…

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This study tests whether a personalized smartphone app can prevent depression and anxiety in adults who do not currently have these conditions. Over 9,000 participants in Spain will use the app, which creates a custom plan with activities like exercise, sleep improvement, and pro…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

This study investigates whether playing 3D motion-sensing games (using Kinect and Google Cardboard) can improve motor control, thinking skills, and quality of life in people with mild to moderate Alzheimer's disease. Participants play specially designed games for 30 minutes a day…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests a special helmet that shines near-infrared light on the brain (called transcranial photobiomodulation) in 40 people with Lewy body dementia. Participants use the helmet twice daily for 6 months. Researchers will check thinking skills, symptoms, and quality of lif…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether a six-week program of automated text or email messages can help reduce stress and burden for people caring for a loved one with dementia. Twenty care partners who previously took part in an observational study will receive educational tips, stress managem…

This study aims to reduce unwanted loneliness and improve the daily experience of family caregivers for people with Alzheimer's disease. Researchers will test a combination of music therapy and health education with 50 caregivers. The goal is to see if these activities can help c…

This study will test whether silkworm pupa powder, taken daily for 12 weeks, can improve memory, daily living skills, and frailty in 100 people with mild-to-moderate Alzheimer's disease. Participants will take the powder twice a day and visit the clinic every 4 weeks for tests in…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This study looks at whether improving sleep can help memory and thinking in older adults with mild memory problems and sleep issues. Fifty participants aged 60-85 will receive either talk therapy for insomnia or gentle sound stimulation during sleep. Researchers will track change…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether a personalized virtual reality program that uses sights, sounds, smells, and tastes can reduce apathy in older adults with cognitive impairment living in nursing homes. Ten participants will attend weekly sessions for six weeks, reliving meaningful memori…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study tests whether a virtual cognitive behavioral therapy for insomnia (CBT-I) program, called REPAIR Sleep, can improve sleep and emotional well-being in people with dementia and their live-in caregivers. Over 5 weekly video sessions, participants learn techniques like set…

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This pilot study will test whether a non-invasive brain stimulation device called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory problems. Eighty participants will receive six sessions of targeted magnetic pulses over three weeks. Researc…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether playing gentle sounds during deep sleep can improve memory and reduce Alzheimer's-related proteins in people with mild cognitive impairment (MCI). About 114 participants, including those with MCI and healthy older adults, will have their sleep monitored a…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests whether giving home health aides extra training on dementia care can reduce troubling behaviors in older adults with dementia or mild cognitive impairment and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs …

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to help with emotions, movement, and social connection. Forty pairs of adults aged 50+ and …

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This pilot study will test whether bright light therapy can help reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers plan to enroll 70 adults on inpatient units at Mayo Clinic. Participants will receive 60-minute sessions of light ther…

This early-stage trial will test whether terazosin, a drug currently used for high blood pressure and enlarged prostate, is safe and tolerable for people with dementia with Lewy bodies. Forty participants will receive either terazosin or a placebo for 15 weeks. The study focuses …

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study will test whether 8 weeks of improvisation music therapy can improve mood and lower stress for people with mild Alzheimer's disease and their care partners. About 40 older adults and their caregivers will attend music sessions and fill out questionnaires before and aft…

This study tests a new text messaging program called CAPTURE for caregivers of people with dementia after an emergency department visit. The program sends up to two tailored texts per day for 30 days, covering topics like symptom monitoring, caregiver well-being, and community re…

This study tests whether dronabinol, a synthetic form of THC (the active ingredient in cannabis), can safely reduce agitation in people with Alzheimer's disease. About 140 adults aged 50 to 90 with Alzheimer's-related agitation will receive either dronabinol or a placebo for 12 w…

This study tests whether a 10-week program combining strength exercises with muscle relaxation techniques can reduce frailty, anxiety, and burden in people caring for a loved one with Alzheimer's. About 62 caregivers will be randomly assigned to either the combined program or rel…

This study tests a program called FPCI-AL that helps staff in assisted living communities interact more positively with residents who have dementia. Researchers will work with staff for several months to improve care interactions. The goal is to reduce residents' behavioral sympt…

This pilot study will test a digital platform called the Dementia Journey Companion (DJC) that helps people with dementia and their caregivers plan future care. Researchers will enroll 150 participants with mild to moderate dementia living at home or in care facilities. The study…

This early-phase study tests whether brivaracetam, a seizure medication, can calm overactive brain areas and improve thinking in 25 adults aged 45–70 with mild Alzheimer's or mild cognitive impairment. Participants will have brain activity monitored via scalp and depth electrodes…

This study tests whether an app called Health enSuite Caregivers can reduce distress in people caring for someone with moderate dementia. The app offers personalized tips on self-care, communication, and time management. Researchers will enroll 400 caregivers to see if using the …

This study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …

This study tests a new digital education program called CARE-Dem for people caring for a loved one with dementia. The program includes videos, fact sheets, and activities to help caregivers understand dementia, communicate better, and find support. Researchers want to see if the …

This study tests whether playing interactive games with a social robot can improve thinking skills, mood, and quality of life in older adults with mild cognitive impairment or dementia. Researchers will randomly assign 80 participants to either 12 weeks of robot game sessions or …

This study tests whether an AI-powered smart electric vehicle can help people with Parkinson's disease or dementia improve their walking and reduce falls. The vehicle monitors gait, gives real-time feedback, and adapts to the user. Researchers will enroll 120 participants aged 50…

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study explores whether drinking beetroot juice twice a day is practical and acceptable for people with mild-to-moderate Alzheimer's disease. Thirty participants will take the juice for one week, with help from a caregiver, to see if they can stick with it and if it causes an…

This study tests a program where specially trained nurses work with families caring for a person with dementia. The nurses help identify and address unmet needs, and a mobile app gives caregivers direct access to experts and memory clinics. The goal is to see if this support help…

This study tests a virtual reality program designed to help family caregivers of people with dementia find a better balance in their lives. Researchers will enroll 60 caregivers to see if the VR experience reduces stress and improves quality of life. The goal is to ease the emoti…

This study tests whether a computer-based stepping game, called Smart±step, can help older adults with mild cognitive impairment (MCI) improve their balance, thinking, and quality of life while reducing their risk of falling. About 70 participants will use the game, which combine…

This study tests whether using a special blend of essential oils at home can improve mood and behavior in people with mild cognitive impairment or early dementia. It also looks at whether this simple, pleasant treatment can reduce stress for their caregivers. Two hundred patients…

This study tests whether a gentle electrical current applied to the scalp (called tACS) can improve memory and thinking in people with mild Alzheimer's disease. Researchers will compare real stimulation to a sham (fake) version in 160 participants. The goal is to see if this safe…

This study tests whether adding an experimental drug (X/T+X-EC) to standard Alzheimer's treatment (lecanemab) is safe and tolerable. About 60 adults with Alzheimer's will receive either the drug or a placebo for 24 weeks. The main goal is to check for side effects, not to measure…

This study tests whether laser acupuncture—using a pen-like device that shines light on specific points on the body—can improve behavioral and psychological symptoms in people with dementia. Sixty participants will receive either real or sham laser treatment three times a week fo…

This study tests a care management checklist designed to guide end-of-life care and hospice transitions for people with advanced dementia and their care partners. Researchers will work with a home healthcare agency to see if the checklist is feasible, acceptable, and usable. The …

This early-phase study will test whether shining near-infrared light on the head each day can help people with mild to moderate Alzheimer's disease. Forty participants will receive 30-minute light sessions six times a week for 96 weeks. Researchers will measure changes in thinkin…

This study tests whether doing physical exercises (like walking and balancing) at the same time as mental tasks (like math or memory games) can improve thinking skills in people with mild Alzheimer's disease. Sixty older adults will be randomly assigned to either this dual-task t…

This study tests whether art therapy—like painting, clay modeling, and collage—can improve thinking and hand skills in people with mild to moderate Alzheimer's disease. Fifty adults aged 60 and older will be split into two groups: one does art therapy twice a week for 8 weeks, th…

This study tests whether listening to music at home can improve the quality of life and reduce burnout in people caring for a loved one with Alzheimer's. Ninety caregiver-patient pairs will be split into groups, with some listening to music or podcasts three times a week for 12 w…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study from Stanford University will look at how people react when they learn their Lewy Body Disease biomarker test results. Researchers will interview and survey 40 participants, both with and without symptoms, to measure distress and other responses over time. The goal is …

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study tests whether a 12-week blended training program can improve dementia knowledge and skills among primary healthcare providers in China. About 240 workers from community health centers will be randomly assigned to either the training or self-study materials. Researchers…

This study will adapt and test an online communication training program called CHATO for nursing home staff who care for people with dementia. The goal is to improve how staff interact with residents, which may reduce behavioral symptoms like agitation or rejection of care. Resea…

This study tests whether an AI-powered smartphone app can accurately measure walking patterns compared to a high-tech motion-capture system. Forty healthy adults will walk with a phone in their pocket while being recorded by cameras. The goal is to see if phones can reliably trac…

This study uses a special full-body PET scan to look for activated T cells (a type of immune cell) in the brain and body of people with Alzheimer's disease. Ten participants with Alzheimer's and some healthy volunteers will get the scan to compare results. The goal is to better u…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study will follow over 3,000 older adults for three years to see how age-related hearing loss is connected to dementia. Researchers will use hearing tests, cognitive assessments, and blood markers to build a 'Hearing Health Clock' and early screening tools. The goal is to be…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This study tests a short program in the emergency department for people with dementia who have fallen. The program includes the patient and their caregiver and aims to reduce future fall-related ER visits. About 700 participants will be split into two groups: one gets the new pro…

This study tests an online training program called DERA for community health workers. The goal is to see if it improves their knowledge about dementia, reduces stigma, and boosts their confidence in helping people with dementia. About 100 community health workers will take the tr…

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study will test if wearable sensors can effectively monitor symptoms and daily function in people with frontotemporal dementia (FTD). Sixty adults with FTD will wear pendant and wrist sensors for two weeks at a time, every six months over two years. The goal is to develop di…

This study tests whether wearable sensors and computerized voice and thinking tests can reliably track symptoms in people with frontotemporal dementia (FTD). Twenty participants will wear sensors and complete assessments at home over 12 months. The goal is to develop digital biom…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…

This study will check if levels of Alzheimer's-related substances in the blood differ among the main ethnic groups living in central Barcelona. Researchers will also look at how age, income, education, and health conditions affect these levels. The goal is to identify barriers to…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study aims to find out how many hospitalized patients in Iraq are malnourished, a problem that can lead to more complications and longer stays. Researchers will screen 300 adults in two hospitals using standard tools to identify those at risk. The goal is to gather data to i…

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This study will test whether a mobile app called MI MOM can improve pregnancy and postpartum health for 500 pregnant women on Medicaid. One group uses the app and gets text messages with health tips, videos, and optional support from a community health worker. The other group rec…

This study will follow 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will not give any treatment but will track safety, brain function, and quality of life for 12 months. The goal is to gather real…

This study will test whether advanced MRI scans and blood tests can predict how well Alzheimer's patients respond to antibody drugs like lecanemab and donanemab. Researchers aim to create personalized models that show when amyloid plaques have been cleared from the brain, potenti…

This study aims to understand how walking patterns, body composition, and a blood protein called BDNF differ between older adults with mild cognitive impairment and healthy older adults. Researchers will measure gait, handgrip strength, and cognitive function in 60 participants a…

This study tests a new AI method to generate a type of brain scan (FDG PET) from another scan (amyloid PET) and an MRI, without needing an extra injection or scan. Researchers will use data from 35 Alzheimer's patients who already had both scans. If it works, it could reduce radi…

This study tests whether watching digital stories can help older adults in rural Vietnam learn about Alzheimer's and related dementias and encourage early diagnosis. Researchers will work with 100 older adults and their caregivers to see if this approach is feasible and improves …

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study will collect health data from 250 Taiwanese adults aged 40 and older to understand how aging affects the brain, sleep, and thinking skills. Participants will undergo brain scans and wear activity monitors, and answer sleep questionnaires. The goal is to build a compreh…

This study tests whether an AI-powered app called HeartBot II can improve women's awareness of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys about their knowledge and confidence in recogn…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study will test if wearable devices like smartwatches and rings can detect early signs of mild cognitive impairment and Alzheimer's disease in 150 adults aged 65 and older. Participants will wear the devices for 30 days while researchers collect data on activity, sleep, and …

This study is testing a digital toolkit that uses AI and wearable sensors to assess pain and distress in people with mild to moderate dementia. The goal is to see if the toolkit is easy to use and accurate. If it works, it could help caregivers better understand and respond to th…

This study will follow 2,800 adults aged 55 and older in China for many years to understand how aging affects the brain and thinking skills. Researchers will collect information on diet, lifestyle, medical history, brain scans, and gut bacteria. The goal is to learn what helps pe…

This study looks at whether eye movement patterns can help detect early cognitive problems in people over 65. Researchers will use special glasses to track eye movements while participants perform visual tasks. The goal is to find a simple, non-invasive way to screen for mild cog…

This study will follow 2,500 elderly people in Hong Kong for 2-3 years to find early signs of Alzheimer's disease. Researchers will use blood tests, brain scans, and memory assessments to see if a simple blood test can detect the disease before symptoms get worse. The goal is to …

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study tests whether a computer-based virtual trainer can improve how new home care workers talk to people with dementia. Researchers will measure changes in workers' knowledge, communication skills, and empathy. The goal is to see if this training method helps caregivers pro…

This study will follow 300 older adults (70+) who have mild cognitive impairment (MCI) for one year to see if feeling lonely makes them more likely to develop dementia. Researchers will track who progresses from MCI to dementia and compare loneliness levels. The goal is to unders…

This study looks at how caring for a family member with Alzheimer's disease affects caregivers' daily lives, emotions, and sense of balance. Researchers will interview and survey 66 caregivers, some who are still caring for a loved one and some who have experienced the loss of th…

This study will use combined PET and MRI scans to measure how the brain uses glucose and oxygen in healthy adults and people with Alzheimer's disease. Researchers want to see if a commercially available ketone drink can improve brain energy metabolism. The study involves 17 parti…

This Stanford study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve memory formation in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). The stimulation is given during learning tasks, and researchers will also l…

This study is developing and testing a screening tool for primary care doctors to spot signs of neglect in older adults with dementia, along with a mobile app called SIRENS that provides caregivers with expert-reviewed information and goal-setting features. The current phase will…

This study aims to create a decision aid to help people with dementia, their caregivers, and doctors talk through medication options together. Researchers will test the tool with 100 patients, caregivers, and clinicians to see if it reduces confusion and improves shared decision-…

This study tests a program designed to reduce stigma around dementia in rural Kenya. Researchers will train local health workers to lead group sessions that teach about dementia, correct myths, and build empathy through videos and discussions. The goal is to see if this approach …