Green tea compound and lifestyle changes may shield high-risk brains from dementia—long-term test underway

NCT ID NCT07730671

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This study follows 121 people who carry the APOE-ε4 gene variant and have noticed subtle memory slips—a group at higher risk for Alzheimer's. They previously completed a 12-month program combining diet, exercise, cognitive training, and a green tea extract (EGCG). Now, researchers will check whether those benefits held up five years later by testing memory, brain scans, blood markers, and lifestyle habits. No new treatment is given; this is a long-term checkup to see if the earlier intervention made a lasting difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
epigallocatechin gallate (EGCG), a compound found in green tea, combined with a multimodal lifestyle intervention (diet, exercise, cognitive training, and vascular risk management)
What this could lead to
If the original benefits last, this could point toward a practical, drug-free way to delay or prevent Alzheimer's in high-risk individuals.
What could go wrong
This is a small follow-up study with no new intervention, so it can only observe whether past effects persist—not prove cause. Results may not apply to the general population.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fundació Pasqual Maragall

    Barcelona, Catalonia, 08005, Spain

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