SUBJECTIVE COGNITIVE DECLINE (SCD)

This study tests a drug called NPC-1 (made of two natural compounds) in 40 adults aged 55+ with early Alzheimer's, mild cognitive impairment, or subjective memory concerns. The goal is to see if it safely changes blood markers linked to Alzheimer's brain changes. Participants tak…

This study tests a smart system that uses facial expressions to adjust computerized brain training in real time, aiming to keep older adults engaged and motivated. Researchers will enroll 80 people aged 60-89 with mild cognitive concerns. The goal is to see if this personalized a…

This study tests whether a home-based digital cognitive-training program called RICORDO can help people aged 50 and older with mild cognitive impairment or subjective cognitive decline better manage their own health. Participants will be randomly assigned to use RICORDO on a tabl…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study tests whether a 24-week online positive psychology program can improve thinking skills and brain function in older adults with very early memory decline (subjective cognitive decline or mild cognitive impairment). About 128 participants will be randomly assigned to the…

This study tests if a fast form of brain stimulation (accelerated dTMS) combined with memory exercises can improve thinking skills in older adults with mild memory issues. About 30 people aged 55-85 with mild cognitive impairment or memory concerns will receive either real or fak…

This study tests a program called the Green Activity Program, designed for people aged 45+ with mild memory problems. The program encourages enjoyable nature activities like walking, gardening, or outdoor yoga, with a partner. Researchers want to see if the program is easy to do …

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

This study looks at whether adding a website and virtual coaching to basic activity tracking can help older adults who live alone, have mild memory concerns, and are not very active. 86 participants will wear a Garmin device, set step goals, and get weekly texts. Half will also g…

This study follows 1,000 adults in Lombardy, Italy, who have early memory complaints but no dementia. Researchers will use blood tests and annual check-ups over 5 years to see if certain biomarkers can predict who later develops Alzheimer's. The goal is to improve early detection…

This study is looking for better, cheaper ways to detect Alzheimer's disease early. Researchers will collect blood samples, brain wave recordings, and speech recordings from 250 people who have noticed memory problems but still function normally. They will use machine learning to…

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…