SUBJECTIVE COGNITIVE DECLINE (SCD)

This early study is testing a combination of two drugs, parthenolide and ipriflavone (called NPC-1), in 40 adults aged 55 and older who have early Alzheimer's or memory concerns. The goal is to see if the treatment is safe and can improve blood markers linked to Alzheimer's brain…

This study tests a facial expression-based personalization engine (FPE) that monitors and adjusts cognitive training in real time to keep older adults engaged. Researchers will enroll 80 people aged 60-89 with mild cognitive impairment or subjective cognitive decline. The goal is…

This study looks at whether adding technology (a website and virtual coaching) to basic education and step tracking can help older adults who live alone and have mild memory concerns become more physically active. The goal is to see if increased activity, social support, and stre…

This study tests whether a 24-week online positive psychology program can improve memory, thinking, and well-being in older adults with very early signs of dementia. About 128 people with subjective cognitive decline or mild cognitive impairment will join. Half take the program (…

This study tests a program called the Green Activity Program, designed for people with mild memory issues or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is eas…

This study tests whether a fast form of brain stimulation (accelerated deep TMS) combined with memory exercises can safely improve thinking skills in older adults with mild memory issues. About 30 participants aged 55-85 with subjective memory decline or mild cognitive impairment…

This study tests whether a digital program called RICORDO can help people aged 50+ with mild memory problems better manage their own health and daily life. Participants will use RICORDO or a standard education program at home for five weeks. Researchers will compare changes in he…

This study tests a simple, non-invasive device that plays soft sounds during sleep to boost deep sleep and improve memory. Sixty older adults with mild memory problems will use the device at home for four weeks. Researchers will measure memory, brain activity, and blood markers t…

This observational study will follow 50,000 people with Alzheimer's or related dementias for many years, collecting medical information from routine doctor visits. Researchers hope to better understand how the disease progresses and how well treatments work in real life. Particip…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study follows 1,000 adults with early memory worries (but no dementia) for up to 5 years. Researchers will use blood tests and thinking assessments to see who has Alzheimer's-related changes and how learning those results affects well-being. The goal is to better understand …

This study aims to find better, cheaper ways to detect Alzheimer's disease early in people who have memory concerns but still function normally. Researchers will collect blood, brain wave recordings, speech samples, and genetic data from 250 participants. They will use machine le…