Could a 20-Minute brain ZAP boost language in memory loss?

NCT ID NCT07449117

Recruiting now Knowledge-focused Sponsor: Masaryk University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation (TIS) can temporarily improve language processing in people with mild cognitive impairment due to Parkinson's disease, Lewy body disease, or amnestic MCI. Seventy participants will receive either real or sham stimulation while performing a sentence comprehension task. Researchers will measure changes in brain activity and connectivity using MRI scans immediately after stimulation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Temporal Interference Stimulation (TIS) - a non-invasive brain stimulation device
What this could lead to: If it works, this could point toward a new way to temporarily boost language and thinking in people with mild cognitive impairment.
What could go wrong: This is a very early, small study (70 people) looking only at immediate effects. It may not lead to any lasting benefit or treatment.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Lewy body dementia neurodegenerative disease Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEWY BODY DISEASE WITH MILD COGNITIVE IMPAIRMENT MILD COGNITIVE IMPAIRMENT (MCI) AMNESTIC PARKINSON'S DISEASE WITH MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

CEITEC MU (Central European Institute of Technology, Masaryk University)
RECRUITING

Brno, South Moravian, 625 00, Czechia

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