Hope for Alzheimer's agitation: new drug enters final testing

NCT ID NCT05397639

Recruiting now Symptom relief Sponsor: Suven Life Sciences Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether masupirdine, a daily tablet, can safely reduce agitation in people with Alzheimer's dementia. About 375 participants will receive either masupirdine or a placebo. The main goal is to see if the drug improves agitation symptoms, which can include aggression and restlessness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: masupirdine (SUVN-502)
What this could lead to: If it works, this could provide a new treatment option to reduce agitation in people with Alzheimer's dementia, improving quality of life.
What could go wrong: This is a phase 3 trial, but previous studies may have failed or shown modest effects. Agitation is hard to measure, and the drug may not outperform placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Psychomotor Agitation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGITATION ALZHEIMER'S TYPE DEMENTIA

Contacts and locations

Locations

ATP Clinical Research, Inc.
RECRUITING

Costa Mesa, California, 92626-4607, United States
Advanced Research Center, Inc.
RECRUITING

Anaheim, California, 92805-5854, United States
Allied Biomedical Research Institute
RECRUITING

Miami, Florida, 33125-2607, United States
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030-4202, United States
Brainstorm Research
RECRUITING

Miami, Florida, 33176, United States
CCM Clinical Research Group
RECRUITING

Miami, Florida, 33133, United States
Central Miami Medical Institute
RECRUITING

Miami, Florida, 33125, United States
Centrum Leczenia Zaburzen Pamieci Affidea
RECRUITING

Warsaw, Masovian Voivodeship, 04-148, Poland
Centrum Medyczne Silmedic Sp z o o
RECRUITING

Katowice, Silesian Voivodeship, 40-282, Poland
ClinHouse Centrum Medyczne
RECRUITING

Zabrze, 41-807, Poland
Clinical Centre of Vojvodina, Clinic of Neurology
RECRUITING

Novi Sad, 21000, Serbia
Clinical Hospital Center Dragisa Misovic Dedinje
RECRUITING

Belgrade, 11000, Serbia
Clinical Hospital Center Rijeka
RECRUITING

Rijeka, 51000, Croatia
Clinical Trial Network
RECRUITING

Houston, Texas, 77074, United States
Combined Research Orlando Phase I-IV
RECRUITING

Orlando, Florida, 32807, United States
Dent Neurologic Institute
RECRUITING

Amherst, New York, 14226, United States
EMC Silesia Sp. z o.o.
RECRUITING

Katowice, Silesian Voivodeship, 40-353, Poland
FutureMeds Warszawa Centrum
RECRUITING

Warsaw, Masovian Voivodeship, 00-215, Poland
Gadolin Research
RECRUITING

Beaumont, Texas, 77702, United States
Insight Hospital and Medical Center Chicago
RECRUITING

Chicago, Illinois, 60616, United States
Ki Health Partners, LLC
RECRUITING

Stamford, Connecticut, 06905, United States
Klinika za psihijatriju Vrapce
RECRUITING

Zagreb, 10090, Croatia
Leading Edge Research LA, LLC
RECRUITING

Encino, California, 91316, United States
MTZ Clinical Research powered by Pratia
RECRUITING

Warsaw, Masovian Voivodeship, 02-172, Poland
Mary S Easton Center for Alzheimer's Research and Care UCLA
RECRUITING

Los Angeles, California, 90095, United States
Medycyna Milorzab sp. z o.o.
RECRUITING

Lodz, Lódzkie, 90-227, Poland
Miami Jewish Health
RECRUITING

Miami, Florida, 33137, United States
Midlands Neurology and Pain Associates
RECRUITING

Columbia, South Carolina, 29205, United States
Neuro Pain Medical Center
RECRUITING

Fresno, California, 93710-5473, United States
Neuro-Medic Janusz Zbrojkiewicz
RECRUITING

Katowice, Silesian Voivodeship, 40-686, Poland
Neurology Center of North Orange County
RECRUITING

Fullerton, California, 92835-1040, United States
Novel Clinical Research Center, LLC.
RECRUITING

Miami, Florida, 33143, United States
Ocean Medical Research
RECRUITING

Toms River, New Jersey, 08755, United States
Polyclinic Neuron
RECRUITING

Zagreb, 10000, Croatia
Quantum Laboratories Inc
RECRUITING

Pompano Beach, Florida, 33064, United States
Ralph H. Johnson VA Health Care System
RECRUITING

Charleston, South Carolina, 29401-1113, United States
Re:Cognition Health
RECRUITING

Chicago, Illinois, 60611, United States
Re:Cognition Health
RECRUITING

Fort Worth, Texas, 76104, United States
Special Hospital for Psychiatric Diseases
RECRUITING

Kovin, 26220, Serbia
University Clinical Center Kragujevac, Clinic for Psychiatry
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center Nis, Clinic for neurology
RECRUITING

Niš, 18000, Serbia
University Hospital Center Zagreb
RECRUITING

Zagreb, 10000, Croatia
Velocity Clinical Research, Cleveland
RECRUITING

Beachwood, Ohio, 44122, United States
Velocity Clinical Research, Syracuse
RECRUITING

East Syracuse, New York, 13057, United States

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