Could a pain device help rare brain disease sufferers?

NCT ID NCT05653778

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether scrambler therapy, a device that uses mild electrical signals on the skin, can reduce nerve pain in people with corticobasal syndrome (CBS). Twenty-five adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scrambler therapy or standard TENS treatment. The main goal is to see if pain scores drop by at least one-third after one month, which would support larger future trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Scrambler therapy (device) and TENS (device)
What this could lead to: If it works, this could point toward a non-drug way to manage nerve pain in corticobasal syndrome.
What could go wrong: This is a very small pilot study (25 people) with no blinding, so results may not be reliable or apply to others. Pain relief may be temporary or no better than TENS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CORTICOBASAL DEGENERATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Corticobasal Degeneration corticobasal degeneration disorder corticobasal syndrome neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORTICOBASAL DEGENERATION CORTICOBASAL SYNDROME PAIN, NEUROPATHIC

Contacts and locations

Locations

Johns Hopkins School of Medicine
RECRUITING

Baltimore, Maryland, 21205, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.