University Of Alabama At Birmingham

This study tests a smartphone-based digital training program designed to improve working memory in people with schizophrenia or related disorders. Participants use the app to practice cognitive exercises, and researchers measure changes in memory and mental health. The goal is to…

This Phase II trial tests whether a combination of therapeutic plasma exchange (filtering the blood), rituximab (a drug that targets certain immune cells), and intravenous immunoglobulin (IVIg) can slow lung decline in people with progressive idiopathic pulmonary fibrosis (IPF). …

This pilot study tests whether a 10-week behavioral program can help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. The program includes medically tailored meals, a YMCA membership, and a meditation component. Researchers will follow 64 partic…

This study looks at whether adding the Nutu digital health platform to a standard weight loss program helps people with obesity lose more weight and improve heart health. About 300 adults in the FLOW program will be offered Nutu, which includes AI coaching and tracking tools. The…

This study tests two different times to perform gum grafting using a special skin substitute (acellular dermis) around dental implants. Forty adults with a single missing tooth will receive the graft either at implant placement or at a later uncovering step. Researchers will meas…

This study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…

This study will test whether measuring blood pressure at home and having weekly phone meetings with a pharmacist can help control high blood pressure. About 420 adults from two emergency department clinics will take part. Half will use the home monitoring and telehealth program f…

This study tests whether adding DHA/ARA supplements to the milk of extremely premature babies (born at 28 weeks or earlier) during their first two weeks of life can reduce the severity of bronchopulmonary dysplasia, a chronic lung disease. About 150 babies will be randomly assign…

This study compares two telehealth approaches—digital health coaching and remote patient monitoring—to see which works better for managing type 2 diabetes in people with physical disabilities and at least one other chronic condition. About 5,000 participants will be randomly assi…

This study looks at whether eating all meals within an 8-hour window earlier in the day can improve heart health in adults aged 60 and older who have high blood pressure and often skip breakfast. Over 12 weeks, participants will either follow this eating schedule or stick to thei…

This study compares two barrier materials used in guided bone regeneration to rebuild the jawbone in areas where teeth are missing. Seventy adults needing horizontal ridge augmentation will be randomly assigned to receive either acellular dermal matrix or a resorbable collagen me…

This study looks at whether combining peer support with remote patient monitoring can help Black adults with uncontrolled type 2 diabetes improve their blood sugar levels. About 200 participants from Alabama will use the program for 6 months. The goal is to see if this approach l…

This study tests whether a 3-month support program, led by a nurse and a community health worker and guided by an AI tool called MEDBRIDGE, can help people with type 2 diabetes manage their medications after leaving the hospital. The program aims to reduce confusion about medicat…

This study tests different weight-loss strategies for adults aged 50 to 75 with obesity. Participants will follow either a high-protein or standard-protein diet for 16 weeks. Those who don't respond well may then receive extra protein supplements or resistance exercise training. …

This phase 2 trial tests the drug mirdametinib, alone or with radiation, in people with NF1-related high-grade gliomas (aggressive brain tumors). It includes three groups: those with recurrent sporadic glioblastoma, newly diagnosed NF1-associated glioblastoma, and other NF1-relat…

This study tests whether two dietary supplements—tauroursodeoxycholate (a bile acid) and a traditional Chinese medicine formula—can help people with diabetic macular edema, a vision-threatening complication of diabetes. The 69 participants will take the supplements or a placebo f…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study tests whether a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin to treat congenital syphilis in newborns up to 30 days old. About 374 infants across 12 U.S. sites will be randomly assigned to one of the two treatments. The goal i…

This study compares two treatments for irreversible pulpitis, a condition causing severe tooth pain. The standard treatment is a root canal, but researchers want to see if a less invasive procedure called pulpotomy works just as well. The study will involve 138 people and also lo…

This early-phase trial tests a combination of three drugs—selumetinib, ZEN-3694, and durvalumab—in people with advanced sarcomas, including malignant peripheral nerve sheath tumors (MPNST) linked to NF1. The study first checks safety and dosing, then looks at whether the treatmen…

This study tests whether using remote blood pressure monitors and video doctor visits can help people living in rural areas better manage their heart failure. Researchers will enroll 32 adults with heart failure to see if this approach is practical and acceptable. The goal is to …

This study tests whether vericiguat, a drug already used for heart failure, can improve how the body uses sugar and burns energy in Black adults with obesity and insulin resistance. Researchers will give 200 participants either vericiguat or a placebo daily for 12 weeks, measurin…

This study compares two surgical methods for repairing a torn ACL: using a graft from your own tendon (autograft) versus using donor tissue plus an extra stabilizing procedure (allograft with LET). The goal is to see which approach leads to better knee stability, strength, and he…

This early-stage study tests a new nose spray version of the drug octreotide for people with diabetic macular edema, a condition that causes vision loss from fluid buildup in the eye. The trial will include 60 adults whose eye swelling has not improved with standard treatments. R…

This first-in-human study will test a new radioactive imaging agent called MeFAMP to see if it can safely and accurately detect brain tumors using PET scans. The study includes 28 people: healthy volunteers and patients with recurrent high-grade glioma or brain metastases from ot…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if …

This study tests whether having trained peer workers deliver HIV prevention medication (PrEP) in community settings helps more young people in Brazil start and stay on PrEP compared to standard clinic care. About 1,400 youth aged 15-24 who are sexually active and not currently us…

This study will test a mobile app designed to help people with schizophrenia or those at high risk for psychosis recognize and change biased thinking patterns. One hundred participants will use the app and report on their mood and negative symptoms. The goal is to see if this sim…

This pilot study tests whether eye movement training can help people who lost part of their vision after a stroke. Twenty participants will either use an eye-tracking machine in the clinic or do reading exercises at home. Researchers will measure changes in eye movements and read…

This study tests whether a ketogenic diet (low carb, high fat) is better than a standard diet at preserving muscle function in older adults hospitalized with pneumonia. Researchers will enroll 30 patients aged 55 and older and measure handgrip strength and diet adherence. The goa…

This study tests a 12-week online program designed to improve mood and motivation in people with schizophrenia or early psychosis. Participants complete 20-30 minute weekly sessions. Researchers will measure changes in symptoms and goal-directed behavior before and after the prog…

This study compares two common dental implant placement methods to see which is more accurate and leads to better healing. Forty adults needing a single tooth implant will be randomly assigned to one of the two methods. Researchers will track implant accuracy, bone loss, and pati…

This pilot study will test whether active music therapy (with a therapist) or passive music therapy (just listening to music) can improve exercise ability and motivation in 28 people with Parkinson's disease. Participants will do sit-to-stand and walking tests while receiving mus…

This study will test whether Pycnogenol, a supplement from French maritime pine bark, can reduce symptoms of Gulf War Illness like fatigue, pain, and brain fog. Twenty male veterans who have already been in a related study will take either Pycnogenol or a placebo for up to 12 mon…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study tests whether adding a short course of the steroid methylprednisolone to standard pain medicine can reduce the need for strong narcotic painkillers after ACL knee surgery. About 64 people aged 14 to 65 will be randomly assigned to get either the steroid plus standard c…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This pilot study will test whether a remotely delivered mindfulness-based diabetes education program, combined with home blood sugar monitoring, is feasible and acceptable for rural Black adults with type 2 diabetes and high diabetes distress. The program is compared to standard …

This study tests whether a virtual reality exercise program, done at home with telehealth coaching, can help children with cerebral palsy become more physically active. 130 kids aged 10 to 17 will either play seated arm exercise games using a VR headset for 12 weeks or continue t…

This study tests whether a low dose of naltrexone can reduce fatigue in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will enroll 75 adults from Alabama and track their fatigue levels weekly through online surveys. The goal is to find the be…

This study tests a device called TearCare that warms the eyelids and manually clears blocked oil glands in young adults (ages 18-29) with dry eye disease. 45 participants will receive one treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. T…

This study compares two ways of giving Botox injections to treat voice tremor, a condition that causes a shaky voice. About 30 adults with essential voice tremor will receive either a standard injection guided by muscle signals or a newer injection into a different part of the vo…

This pilot study will test whether a high-fat, low-carbohydrate ketogenic diet can reduce symptoms of bipolar disorder when added to standard treatments. The study will enroll 100 adults in rural Alabama and measure changes in mania severity. The goal is to see if a dietary appro…

This study will test whether eating flaxseed, a source of omega-3 fatty acids, can help reduce pain and improve daily life for children with sickle cell disease. Twenty children aged 5 to 18 will take part. The main goal is to see if it's possible for them to eat flaxseed regular…

This study tests a virtual group program called Breath-Body-Mind (BBM) that uses slow breathing and gentle movements to help young breast cancer survivors (ages 18-50) cope with psychological distress. Thirty participants will be randomly assigned to either the BBM program or a g…

This study tests whether a special dental surgery called PAOO, done before braces, helps move back molars faster and with less discomfort. Forty adults with misaligned teeth will be randomly assigned to get braces alone or braces plus PAOO. Researchers will measure tooth movement…

This study will test whether spending time in a park—either by moving along a trail or by relaxing and engaging the senses—can improve emotional well-being and reduce stress in adults who use manual wheelchairs. Ten participants will try both activities over 10 weeks. Researchers…

This study tests a smartphone app that predicts when preterm babies will have pauses in breathing (apnea) and slow heart rate (bradycardia). The app then triggers gentle stimulation to prevent these episodes. The study will include 25 preterm infants born before 32 weeks who have…

This study tests whether an internet-based physical activity program can improve sexual dysfunction in women with relapsing-remitting multiple sclerosis. Thirty women with MS and sexual problems will use a website and have video chats with a coach to increase their physical activ…

This study tests a structured program to help 40 adolescents and young adults with congenital adrenal hyperplasia (CAH) move from pediatric to adult healthcare. Participants will learn about their condition, emergency preparedness, and self-management. The goal is to see if the p…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study looks at whether the time of day you eat can affect brain health in people with multiple sclerosis. Twenty-two adults with MS will follow a daily eating schedule for a set period. Researchers will measure markers of nerve health and inflammation in the blood. A small g…

This study uses a non-invasive forehead sensor to continuously monitor brain oxygen levels in 120 patients with subarachnoid hemorrhage (a type of stroke caused by bleeding around the brain). The goal is to see how the brain's ability to regulate blood flow changes over time and …

This study looks at how a specific gene change (AGXT) affects oxalate production in people who have had calcium oxalate kidney stones. Four participants will eat a low-oxalate diet for five days and then receive an intravenous dose of glycolate. Researchers will measure oxalate l…

This study tests whether a robot called NeuraSignal can measure blood flow in the brain of patients recovering from spinal surgery. The goal is to create personalized blood pressure targets for each patient. The study will include 20 adults in the neuro ICU. It is a feasibility s…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early warning signs in hospitalized children in Ghana. About 250 children with traumatic injuries or after appendix surgery will wear the wat…

This study will test whether using a special ultrasound technique called VeXUS to guide fluid treatment can help protect kidney function in 100 ICU patients with acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and lasting kidney damage. Th…

This study uses blood samples from 20 dental patients to see how well a bone-growth protein (rhBMP-2) sticks to a natural blood-derived scaffold (E-PRF) and releases over time. Researchers compare this to the standard sponge carrier and combinations. The goal is to find a better …

This study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Partic…

This study will follow 86 women scheduled for mastectomy to understand why some develop long-term pain while others recover smoothly. Researchers will test pain sensitivity before surgery, analyze blood for inflammation markers, and assess emotional health and life stressors. The…

This study looks at why some people have more pain than others after colorectal surgery. Researchers will test pain sensitivity, analyze blood for inflammation, and ask about emotional health and life stress. The goal is to find better ways to manage pain and prevent long-term di…

This study looks at how genes influence heart hormones called natriuretic peptides, which help control blood pressure and metabolism. Researchers will give 200 adults with mild high blood pressure low-salt and high-salt diets, plus a saline infusion, to see how their blood pressu…