University Of Alabama At Birmingham

This study aims to see if two different pneumococcal vaccines can create antibodies that effectively kill newly discovered and related strains of bacteria that cause pneumonia and other infections. Researchers will give the vaccines to 70 healthy adults who have never received a …

This study is testing whether two oral supplements can help control diabetic macular edema (DME), a swelling in the eye caused by diabetes. Researchers believe targeting liver health and body-wide inflammation may be a better long-term strategy than current eye injections. The tr…

This study is testing whether giving a special nutrient-enriched human milk diet in the first two weeks of life can help the lungs of extremely premature babies. Researchers will compare this special diet to standard nutrition in 150 babies born at 28 weeks or earlier. The goal i…

This study aims to compare two different triple-combination inhalers for adults with moderate-to-severe asthma that isn't fully controlled. Twenty participants will try each inhaler for 8 weeks, with tests to see how well each one opens airways and improves asthma symptoms. The g…

This study is testing a program called PROMOTE, which combines peer support from trained community health workers with remote monitoring of blood sugar levels. It aims to help 200 Black adults in Alabama who have uncontrolled type 2 diabetes better manage their condition. The goa…

This study aims to find the best personalized approach to help adults aged 50-75 with obesity lose weight while keeping their muscle. Researchers will test different diet plans (high vs. standard protein) and add extra support like protein shakes or guided exercise if someone isn…

This study is testing whether adding a digital health app called Nutu™ to a standard primary care weight management program helps people lose more weight. It will involve 300 people already enrolled in a year-long behavioral program for obesity. Researchers will compare weight ch…

This study compares two dental treatments for severe tooth nerve pain: traditional root canal treatment versus a simpler procedure called pulpotomy. Researchers will follow 138 patients for two years to see which approach works better at relieving pain and preserving teeth. The s…

This study is testing whether a prescription eye drop called Vevye can help adults with meibomian gland dysfunction (MGD), a common condition that causes dry, irritated eyes. About 48 participants will use the drops twice daily for six months while researchers check for improveme…

This study aims to see if a new sonic cleaning system (GentleWave) is better than the standard method at cleaning bacteria from infected root canals during a second treatment. Researchers will compare the two methods in 60 people who need a root canal re-treatment on a back molar…

This study aims to find out which of two telehealth approaches works better to help adults with physical disabilities manage type 2 diabetes and other chronic health conditions. It will compare digital health coaching (personal guidance) with remote patient monitoring (tracking h…

This study aims to improve surgery recovery for patients who struggle with health information. It will test a new support program called VISACT, which uses visual aids and coaching to help these patients better follow their recovery plans. The goal is to reduce hospital stays, co…

This study tests a bundled support program for people who have survived an opioid overdose and visited the emergency department. The program combines telehealth check-ins, peer support, medication (buprenorphine), and help connecting to long-term care. Researchers want to see if …

This study is testing if a drug called vericiguat can improve heart and metabolic health in Black adults with obesity and insulin resistance. Researchers will enroll 200 participants to take either the drug or a placebo pill daily for 12 weeks. The main goals are to see if the dr…

This study is testing whether remote care using home blood pressure monitors and video consultations can help people with heart failure who live in rural areas manage their condition better. Researchers will work with 32 participants to see if this approach is practical and accep…

This study is testing if a special low-carbohydrate, high-fat diet (ketogenic diet) is better than standard hospital food at helping older adults with pneumonia keep their muscle strength and function while they recover in the hospital. Researchers will compare the two diets in 3…

This study aims to find out if a 10-day course of oral amoxicillin works as well as the standard single penicillin injection for treating possible congenital syphilis in newborns. Researchers will enroll about 374 infants 30 days old or younger across 12 U.S. sites. The trial wil…

This study is testing whether using a special ultrasound scan (called VExUS) to guide how much fluid to give critically ill patients can help protect their kidneys. It will involve 100 adults in intensive care who have developed sudden kidney injury. Doctors will compare outcomes…

This study aims to see if a different mouth rinse helps people heal better after having a tooth pulled and receiving a bone graft. Researchers will compare a common antiseptic rinse (chlorhexidine) against another type (EDTA) used right after surgery and daily. They will measure …

This study compares two surgical approaches for repairing a torn ACL knee ligament. It will test whether using donor tissue combined with an extra stabilizing procedure works as well as using the patient's own tissue. The goal is to see if the donor approach can provide good resu…

This early-stage study is testing whether a medicine called octreotide, delivered as a nasal spray, can safely reduce swelling in the back of the eye (macular edema) caused by diabetes. It is for people whose eye swelling hasn't improved enough with the standard treatment of inje…

This study is testing whether giving caffeine citrate to moderately preterm babies for 28 days after they leave the hospital can prevent dangerous pauses in breathing (apnea) that lead to emergency visits. It will also check if this treatment helps the babies' development at 12 m…

This study is testing a new combination of three drugs (selumetinib, ZEN-3694, and durvalumab) for people with advanced sarcomas that have not responded to standard treatments. The first part of the trial will find safe doses, and the second part will focus on a specific, aggress…

This study is testing whether using consumer smartwatches can help nurses monitor children's vital signs more effectively in Ghanaian hospitals. It will involve 250 children who are either recovering from trauma or from appendix surgery. The goal is to see if the continuous data …

This study is testing a short, interactive digital toolkit designed to help women in Alabama and Mississippi learn about and start taking PrEP, a medication that prevents HIV. About 125 women at three clinics will use the toolkit on a tablet and then talk with a healthcare provid…

This study is testing whether adding folic acid to regular cooking salt can effectively raise folate levels in the blood of women in Zambia. The goal is to see if this simple, everyday change could help prevent serious birth defects of the brain and spine in future pregnancies. A…

This study aims to see if having young people (ages 15-24) trained to provide HIV prevention medication (PrEP) to their peers in community settings works better than the standard clinic-based care in Brazil. It will involve 1,400 young people who are at risk for HIV but not curre…

This study tests whether remote mindfulness education can help rural Black adults better manage type 2 diabetes and reduce the emotional distress that often comes with the disease. Researchers will compare an 8-week mindfulness program delivered via Zoom to standard diabetes educ…

This study is testing a new device and app designed to predict and stop dangerous breathing pauses and slow heart rates in premature babies. It will monitor 25 infants and use gentle vibrations to try to interrupt these episodes before they occur. The goal is to see if this gentl…

This study is testing a 12-week online program designed to improve mood and motivation in people with schizophrenia or those at high risk for developing psychosis. Participants will complete one 20-30 minute session each week, focusing on supporting goal-directed behavior. The st…

This study is testing a personalized therapy approach for people with anxiety. First, participants track their anxiety symptoms five times a day for two weeks using their phones. Therapists then use this data to create a custom treatment plan, which includes up to 25 weekly couns…

This study is testing whether a natural supplement called Pycnogenol, made from French maritime pine bark, can help reduce the severity of Gulf War Illness symptoms like fatigue, pain, and brain fog. Researchers believe the illness involves inflammation and that this botanical ma…

This study is testing if wearing tinted contact lenses can help reduce painful light sensitivity (photophobia) that people often experience after a concussion. Researchers will enroll 60 adults who have had a mild concussion within the last two years and are struggling with light…

This study is testing whether taking a cocoa supplement daily while doing regular exercise improves walking ability and leg strength more than exercise alone in older adults who walk slowly. It will involve 36 participants over age 55 who will do supervised walking and strength t…

This study is testing if a 16-week online exercise program can help improve sexual function for women with multiple sclerosis (MS). Researchers will enroll 30 women with MS who report sexual difficulties and who are not currently very active. The goal is to see if increasing phys…

This study is testing if taking an oral medication called tranexamic acid for a period after total shoulder replacement surgery helps patients recover better in the short term. It will compare patients who receive the medication to those who do not, looking at outcomes like pain …

This study is testing whether low doses of the medication naltrexone can help reduce the severe fatigue experienced by people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will enroll 75 adults from Alabama in a 10-month remote trial where particip…

This study is testing a brief mobile phone app designed to help improve mood by addressing unhelpful thinking patterns. It will involve 100 people who either have schizophrenia or are at high risk for developing psychosis. The main goal is to see if the app is helpful and easy to…

This study is testing whether adding a wearable device, like a smartwatch, to an existing remote symptom-tracking program helps cancer patients and their care teams. It aims to see if the device is easy for patients to use and if the data it collects relates to the symptoms patie…

This small pilot study aims to see if two different types of eye training can help people who have lost half of their field of vision after a stroke. Researchers will compare a clinic-based eye-tracking training program to a set of at-home reading exercises. The goal is to learn …

This study is testing if adding a minor gum surgery helps move back teeth faster during adult orthodontic treatment. Researchers will compare standard braces to braces combined with this surgery in 40 adults with misaligned bites. They want to see which method moves teeth quicker…

This study aims to see if spending time in an urban park can help reduce stress and improve emotional well-being for adults who use wheelchairs or have other mobility impairments. Researchers will compare two different 30-minute park activities over 10 weeks: gentle physical acti…

This study aims to understand how different types of exercise affect the brain's ability to learn and adapt in older adults and people who have had a stroke. Researchers will compare high-intensity cycling, low-intensity cycling, and a health education group to see how exercise i…

This study is testing whether a new robotic ultrasound device can be used to measure how well the brain regulates its own blood flow. It will involve 20 adult patients in a neurological intensive care unit who are recovering from spinal surgery. The goal is to see if this robotic…

This is a laboratory study to see if a material made from a patient's own blood (E-PRF) can hold and slowly release a bone growth protein (rhBMP-2) better than the currently approved sponge. Researchers will compare how the protein is released from the blood product, the standard…

This study aims to understand how a person's genetic makeup influences levels of important heart hormones called natriuretic peptides, and how this affects blood pressure changes in response to high- and low-salt diets. Researchers will enroll 200 adults with mild to moderate hig…

This study aims to understand how the brain's ability to control its own blood flow changes over time in patients who have had a serious type of stroke called a subarachnoid hemorrhage. Researchers will monitor 120 patients in the intensive care unit using special sensors on the …

This study aims to understand why some people experience more severe or longer-lasting pain after breast cancer surgery (mastectomy). Researchers will test 86 patients before and after surgery, measuring their pain sensitivity, blood markers, and psychological factors. The goal i…

This study is testing two simple smell-based activities to see if they are practical and acceptable for middle-aged and older adults living with HIV. Researchers want to know if regularly smelling scents at home for 8 weeks can improve participants' sense of smell and their cogni…

This early study is testing a new radioactive tracer called MeFAMP for PET scans to see if it can safely and clearly show brain tumors. It will first check safety in healthy volunteers, then test the tracer in patients with recurrent high-grade glioma or brain metastases from oth…

This study aims to understand if restricting daily eating to a specific time window affects brain health in people with multiple sclerosis (MS). Researchers will measure markers of brain cell health, inflammation, and body clock genes in 22 adults with MS. Participants will be as…

This study aims to understand if a specific type of drug for cystic fibrosis (CFTR modulators) can improve how the body handles blood sugar in people who also have cystic fibrosis-related diabetes (CFRD). Researchers will compare two groups of people with CFRD: those taking the C…

This study aims to understand why some people experience more severe or longer-lasting pain after colon surgery. Researchers will test pain sensitivity before surgery, analyze blood samples, and ask about life factors like stress and emotional health in 128 patients. The goal is …