University Of Alabama At Birmingham

This early-stage study tests a nose spray form of octreotide for diabetic macular edema, a condition that causes vision loss. It includes 60 adults who haven't responded well to current treatments. The goal is to see if the spray is safe and can reduce retinal swelling and improv…

This study tests a drug called mirdametinib, alone or with radiation, in people with a type of brain cancer (high-grade glioma) linked to the genetic condition NF1. The trial has three groups: one for recurrent glioblastoma with NF1 changes, one for newly diagnosed NF1-related gl…

This study looks at whether adding the Nutu™ digital health platform to standard weight-loss care helps people lose more weight and improve heart health. About 300 adults in a primary care program will be randomly offered the app or usual care alone. The main goal is to see if th…

This study tests a new way to treat diabetic macular edema (DME), a serious eye complication of diabetes that causes vision loss. Instead of standard eye injections, researchers will give 69 participants a bile acid supplement and a traditional Chinese medicine formula that targe…

This study tests a program that combines peer support with remote patient monitoring to help Black adults with uncontrolled type 2 diabetes. About 200 participants will use the program for 6 months, and researchers will track changes in blood sugar and blood pressure. The goal is…

This study compares two telehealth approaches—digital health coaching and remote patient monitoring—to see which works best for managing type 2 diabetes in people with physical disabilities and at least one other chronic condition. About 5,000 participants will be followed for 12…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend twice-monthly sessions on diet, activity, and coping, and are paired with a community health w…

This study tests whether using remote blood pressure monitors and video doctor visits can help people with heart failure who live in rural areas better manage their condition. Researchers will enroll 32 participants to see if this approach is practical and acceptable. The goal is…

This study compares two ways to fix a torn ACL in the knee. One method uses a piece of your own tendon, the other uses donated tissue plus an extra stitch to stabilize the knee. Researchers will measure how stable the knee is, how strong the muscles get, and how the new ligament …

This study tests whether vericiguat, a drug that boosts a natural signaling molecule called cGMP, can improve how the body uses energy and responds to insulin. It involves 200 Black adults with obesity and insulin resistance. Over 12 weeks, participants will receive either verici…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study tests whether a 10-day course of oral amoxicillin works as well as a single shot of penicillin for newborns with possible congenital syphilis. About 374 infants up to 30 days old will take part at 12 U.S. sites. The goal is to find a treatment that is easier to give an…

This study tests whether giving extremely premature babies (born at 28 weeks or earlier) a special diet of fortified human milk with added DHA and ARA during their first two weeks of life can reduce lung damage and improve breathing. About 150 babies will take part, and researche…

This study tests a program for people with opioid use disorder who have had an overdose. After leaving the emergency room, participants get telehealth visits, a peer support specialist, and medication (buprenorphine) to help them stay in treatment. The goal is to reduce repeat ov…

This study tests whether Vevye eye drops (cyclosporine 0.1%) can improve symptoms and signs of meibomian gland dysfunction (MGD), a common cause of dry, burning eyes. About 48 adults with moderate-to-severe MGD will use the drops twice daily for 24 weeks. Researchers will measure…

This study tests a 10-week behavioral program to help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. 64 adults who lost at least 15% of their body weight on these drugs will be followed for 6 months. The program includes meal plans, gym member…

This study tests a combination of three drugs (selumetinib, ZEN-3694, and durvalumab) in people with advanced sarcomas, including a rare nerve tumor called MPNST. The goal is to see if the combination is safe and can shrink tumors or stop them from growing. About 41 adults with s…

This study tests different combinations of diet, extra protein, and resistance exercise to help 250 adults aged 50-75 with obesity lose weight while keeping muscle. Participants will follow a personalized plan over 52 weeks. The goal is to find the best approach for healthy weigh…

This study tests whether a ketogenic (low-carb, high-fat) diet helps older adults hospitalized with pneumonia maintain muscle function better than a standard hospital diet. Researchers will enroll 30 patients aged 55 and older and track safety, diet adherence, and handgrip streng…

This early-phase study tests a new radioactive imaging agent called MeFAMP to see if it can safely and accurately detect brain tumors using PET scans. The study includes healthy volunteers and people with recurrent brain tumors or tumors that spread from other cancers. The goal i…

This study tests a quick digital toolkit that helps cisgender women learn about PrEP, a daily pill that prevents HIV. About 125 women in Alabama and Mississippi will use the toolkit on a tablet at their clinic and then talk with a healthcare provider about starting PrEP. Research…

This study tests whether training young people to deliver HIV prevention pills (PrEP) to their peers can increase use and adherence compared to standard clinic care. About 1,400 sexually active youth aged 15-24 in Brazil who are not currently taking PrEP will be randomly assigned…

This study tests whether giving caffeine citrate to moderately preterm infants for up to 28 days after hospital discharge can prevent dangerous breathing pauses (apnea) that lead to sick visits. About 340 babies in Zambia will receive either caffeine or a placebo daily, with pare…

This study tests whether mailing fentanyl test strips and providing education can reduce opioid overdoses. One hundred adults who use opioids or stimulants will be randomly assigned to receive test strips, education, both, or neither. The goal is to find the most effective and co…

This study tests whether adding folic acid to iodized salt can raise folate levels in women aged 18-45 in Zambia, where food is not fortified with folic acid. About 250 non-pregnant, non-lactating women will use the special salt instead of their regular salt for 6 months and have…

This study tests whether placing a soft tissue matrix over a nerve in the arm during reconstructive surgery can prevent long-term nerve pain and numbness. About 80 adults with head and neck cancer who need a forearm flap will be randomly assigned to get the matrix or standard clo…

This study tests a device called TearCare that warms the eyelids and helps unclog oil glands in young adults aged 18 to 29 with dry eye disease. 45 participants will receive a single treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. The go…

This study tests a 12-week online program designed to improve mood and motivation in people with schizophrenia or early psychosis. Participants complete weekly 20-30 minute sessions from home. The goal is to help them feel more motivated and engaged in daily activities. The study…

This pilot study tests whether a remotely delivered mindfulness-based diabetes education program, combined with home blood sugar monitoring, is feasible and acceptable for rural Black adults with type 2 diabetes who have high stress and poorly controlled blood sugar. The study wi…

This pilot study tests two types of eye training to help people who lost part of their vision after a stroke. One group will use a special eye-tracking machine in the clinic, while the other will do reading exercises at home. Researchers want to see which method improves eye move…

This study will test a process-based therapy for adults with anxiety. Ten participants will use a mobile app to learn skills to manage their anxiety. The goal is to see if this approach reduces anxiety symptoms and improves quality of life.

This study tests whether a very low dose of naltrexone can reduce fatigue in people with ME/CFS. About 75 adults in Alabama will take the drug and report their fatigue levels weekly. The goal is to find the best dose for easing symptoms.

This study tests whether eating flaxseed (rich in omega-3) can help children with sickle cell disease have less pain and feel better overall. Twenty children ages 5 to 18 will eat flaxseed daily for several weeks. Researchers will track how easy it is to stick with the diet and w…

This study compares two treatments for a severely painful tooth condition called irreversible pulpitis: a pulpotomy (removing only the top part of the nerve) versus a standard root canal. Researchers will track which treatment works better and look for clues in the patient's pain…

This study compares two ways of giving Botox injections to treat voice tremor, a condition that causes the voice to shake. About 30 adults with essential voice tremor will receive either a standard injection guided by muscle signals or a newer injection into a different part of t…

This study tests a small ear device that gently stimulates a nerve to see if it is safe and comfortable for people who recently had a spinal cord injury. Researchers will also check if using the device before walking therapy might help improve mobility. The study involves 50 adul…

This study looks at whether an online physical activity program can improve sexual dysfunction in women with relapsing-remitting multiple sclerosis. About 30 women who are in a committed relationship and have sexual problems will take part. They will wear a pedometer and complete…

This study tests whether a breath-based group program (Breath-Body-Mind) can reduce psychological distress in 30 young breast cancer survivors (ages 18-50) who are on hormone therapy. Participants will be randomly assigned to either the breath program or a general survivorship ed…

This study compares two ways to move back molars forward using braces: one with a special gum surgery called PAOO and one without. About 40 adults will be randomly assigned to one of the two groups. The goal is to see if the surgery leads to faster tooth movement, less discomfort…

This study tests a brief mobile app designed to reduce negative thinking and improve mood. Researchers will enroll 100 adults with schizophrenia or at clinical high risk for psychosis. Participants use the app and report changes in defeatist beliefs and negative symptoms. The goa…

This pilot study will test whether a high-fat, low-carbohydrate (ketogenic) diet can reduce symptoms of bipolar disorder and improve metabolic side effects when added to standard treatment. The study will enroll 100 adults with bipolar disorder in rural Alabama. Participants will…

This study tests whether Pycnogenol, a natural extract from French maritime pine bark, can reduce symptoms of Gulf War Illness (GWI) like fatigue, pain, and brain fog. Researchers believe inflammation in the body and brain causes these symptoms, and Pycnogenol may help calm that …

This study tests a new app that predicts when preterm infants will have pauses in breathing (apnea) and slow heart rate (bradycardia). The app will then trigger gentle stimulation to prevent these episodes. The study will enroll 25 preterm infants born before 32 weeks who have al…

This study looks at how spending time in a park can help adults with mobility impairments feel better emotionally and reduce stress. Ten participants will try two types of park activities: a calm sensory experience and a more active one like wheeling or walking. The goal is to se…

This study aims to see which of two common dental implant placement methods is more accurate and leads to better healing and less discomfort. About 40 adults needing a single dental implant will participate. Researchers will compare the implant's position to the original plan, ch…

This study tests whether virtual reality exercise games, done at home with telehealth coaching, can help inactive children with cerebral palsy (ages 10-17) become more active and improve their health. 130 participants will either play VR exergames for 12 weeks or be in a control …

This study will compare two ways of doing gum grafts around dental implants using a special skin substitute. The goal is to see which timing—during the first or second surgery—gives better gum thickness and health. About 40 adults with missing teeth will take part. The results wi…

This study compares two brain training programs for adults with long-lasting brain fog after a viral infection, including from COVID-19 or ME/CFS. About 30 participants will do online games and a gentle nerve stimulation over 2-4 weeks, with follow-ups for 6 months. The goal is t…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who are already using CAB-LA or not using PrEP will join groups based on their birth control cho…

This study focuses on helping patients with low health literacy—those who struggle to understand medical information—recover better after surgery. Researchers will test a program called VISACT that uses visual aids, coaches providers in clear communication, and trains hospitals t…

This study observes 120 adults with a type of bleeding stroke called subarachnoid hemorrhage to track how well their brains control blood flow. Researchers use special monitors to see if the ideal blood pressure changes over time and if poor control leads to further brain injury.…

This study looks at why some people have more pain than others after colorectal surgery. Researchers will test pain responses, check blood for inflammation, and ask about emotional health and life stress. The goal is to find better ways to manage pain for each patient. About 128 …

This study looks at how your genes influence heart hormones called natriuretic peptides, which help control blood pressure and metabolism. Researchers will test 200 adults with mild high blood pressure to see how their genes affect hormone levels and blood pressure changes when e…

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early signs of trouble in children admitted for trauma or after appendix surgery. About 250 children will wear the watch, and the number of a…

This study tests whether a robot can safely measure blood flow in the brain of patients recovering from spinal surgery. The goal is to see if the robot can help doctors better manage blood pressure in the intensive care unit. About 20 adults will take part.

This study looks at how a medication called ETI (a CFTR modulator) affects blood sugar control in people with cystic fibrosis-related diabetes (CFRD). Researchers will compare two groups: those who can take ETI and those who cannot due to their genetic mutation. The goal is to un…

This study looks at how short bursts of aerobic exercise might help the brain learn and adapt better in older adults and stroke survivors. About 48 participants will do cycling at different intensities, then complete memory and movement tasks while their brain activity is measure…

This early-stage study looks at whether two types of smell exercises (smelling scents twice a day or using a scent diffuser at night) are acceptable and helpful for adults over 40 with HIV. The main goal is to see if people will stick with the program and if it can improve their …

This study uses blood samples from 20 dental patients to see how well a bone-growth protein (rhBMP-2) sticks to a natural blood-derived material (E-PRF) and releases over time. It compares this to the standard sponge carrier. The goal is to gather lab data, not to treat patients …

This study looks at whether a special ultrasound technique called VExUS can help doctors manage fluids better in ICU patients with acute kidney injury. About 100 adults in intensive care will be observed and some will have their treatment guided by VExUS. The goal is to see if th…

This study looks at why some women have more pain than others after mastectomy. Researchers will test pain responses before surgery, analyze blood for inflammation, and ask about emotional health and life stress. The goal is to find better ways to predict and manage pain during r…

This study aims to understand if restricting daily eating to an 8-hour window impacts brain health and inflammation in adults with multiple sclerosis (MS). Researchers will measure specific markers in the blood and explore how meal timing affects the body's internal clock. The go…